STRINGSTRING
Igni_0042 Igni_0042 pyrB pyrB Igni_0165 Igni_0165 Igni_0171 Igni_0171 pyrD pyrD Igni_0311 Igni_0311 purE purE purA purA Igni_0400 Igni_0400 Igni_0407 Igni_0407 Igni_0408 Igni_0408 purP purP pyrE pyrE Igni_0596 Igni_0596 Igni_0600 Igni_0600 Igni_0637 Igni_0637 purC purC purS purS purQ purQ purF purF Igni_0943 Igni_0943 Igni_1228 Igni_1228 purL purL Igni_1293 Igni_1293 Igni_1294 Igni_1294 guaAA guaAA Igni_1358 Igni_1358 Igni_1399 Igni_1399 carA carA purT purT
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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Your Input:
Igni_0042PFAM: oxidoreductase FAD/NAD(P)-binding domain protein. (220 aa)
pyrBTIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain. (305 aa)
Igni_0165TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase. (461 aa)
Igni_0171Glutamine--fructose-6-phosphate transaminase; TIGRFAM: glucosamine--fructose-6-phosphate aminotransferase, isomerizing; PFAM: glutamine amidotransferase, class-II; sugar isomerase (SIS). (592 aa)
pyrDDihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (302 aa)
Igni_0311Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (319 aa)
purEPhosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (138 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (339 aa)
Igni_0400TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (445 aa)
Igni_0407Glutamate synthase (NADPH) GltB1 subunit; PFAM: glutamine amidotransferase, class-II. (296 aa)
Igni_0408Ferredoxin-dependent glutamate synthase; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase. (717 aa)
purPIMP biosynthesis enzyme PurP-like protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (347 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (188 aa)
Igni_0596TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase. (383 aa)
Igni_0600Amidophosphoribosyltransferase; PFAM: phosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (424 aa)
Igni_0637PFAM: GMP synthase domain protein; PP-loop domain protein. (370 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (235 aa)
purSHypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the am [...] (90 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (219 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (432 aa)
Igni_0943PFAM: IMP biosynthesis enzyme PurP-like. (366 aa)
Igni_1228TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp. (497 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (713 aa)
Igni_1293TIGRFAM: ammonium transporter; PFAM: Rh family protein/ammonium transporter. (407 aa)
Igni_1294PFAM: nitrogen regulatory protein P-II. (116 aa)
guaAAGlutamine amidotransferase class-I; Catalyzes the synthesis of GMP from XMP. (188 aa)
Igni_1358TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase. (211 aa)
Igni_1399TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein. (1047 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; Belongs to the CarA family. (373 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (402 aa)
Your Current Organism:
Ignicoccus hospitalis
NCBI taxonomy Id: 453591
Other names: I. hospitalis KIN4/I, Ignicoccus hospitalis DSM 18386, Ignicoccus hospitalis JCM 14125, Ignicoccus hospitalis KIN4/I, Ignicoccus hospitalis str. KIN4/I, Ignicoccus hospitalis strain KIN4/I
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