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| | Igni_0002 | PFAM: FAD linked oxidase domain protein. (433 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (367 aa) |
| | hisE | PFAM: phosphoribosyl-ATP pyrophosphohydrolase. (102 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (197 aa) |
| | sucD | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa) |
| | sucC | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (376 aa) |
| | Igni_0089 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (248 aa) |
| | Igni_0090 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (234 aa) |
| | Igni_0158 | PFAM: S-adenosylmethionine synthetase (MAT). (401 aa) |
| | Igni_0165 | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase. (461 aa) |
| | Igni_0177 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; Belongs to the HisA/HisF family. (235 aa) |
| | Igni_0199 | TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (461 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (262 aa) |
| | Igni_0222 | Nucleotide kinase-like protein; Related to CMP and AMP kinase. (181 aa) |
| | Igni_0242 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. (208 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (298 aa) |
| | Igni_0256 | PFAM: AMP-dependent synthetase and ligase. (412 aa) |
| | Igni_0261 | PFAM: pyruvate carboxyltransferase. (488 aa) |
| | pgk | PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (408 aa) |
| | Igni_0276 | TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (561 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (215 aa) |
| | Igni_0289 | PFAM: Nucleotidyl transferase. (355 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (186 aa) |
| | Igni_0307 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein. (311 aa) |
| | Igni_0311 | Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (319 aa) |
| | Igni_0324 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (342 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (138 aa) |
| | Igni_0343 | PFAM: inositol monophosphatase. (278 aa) |
| | fbp | Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (387 aa) |
| | Igni_0376 | TIGRFAM: putative hydroxymethylglutaryl-CoA synthase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal domain protein; Belongs to the thiolase-like superfamily. UPF0219 family. (347 aa) |
| | Igni_0377 | Acetyl-CoA acetyltransferase-like protein. (353 aa) |
| | Igni_0383 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (308 aa) |
| | Igni_0384 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (404 aa) |
| | Igni_0388 | TIGRFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; PFAM: flavoprotein. (197 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (263 aa) |
| | Igni_0397 | PFAM: Radical SAM domain protein. (393 aa) |
| | Igni_0400 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (445 aa) |
| | Igni_0406 | PFAM: aminotransferase, class I and II. (373 aa) |
| | Igni_0415 | PFAM: glucose-6-phosphate isomerase. (216 aa) |
| | Igni_0420 | Succinate dehydrogenase subunit C; PFAM: protein of unknown function DUF224, cysteine-rich region domain protein. (262 aa) |
| | Igni_0421 | PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase. (224 aa) |
| | Igni_0428 | TIGRFAM: ribose 5-phosphate isomerase; PFAM: Ribose 5-phosphate isomerase. (221 aa) |
| | Igni_0431 | TIGRFAM: tryptophan synthase, alpha subunit; PFAM: tryptophan synthase, alpha chain. (250 aa) |
| | Igni_0441 | Hypothetical protein. (309 aa) |
| | purP | IMP biosynthesis enzyme PurP-like protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (347 aa) |
| | Igni_0445 | TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin. (319 aa) |
| | Igni_0457 | TIGRFAM: 4-hydroxybenzoate polyprenyltransferase, putative; PFAM: UbiA prenyltransferase. (259 aa) |
| | Igni_0466 | Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I. (201 aa) |
| | Igni_0476 | TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family. (408 aa) |
| | Igni_0483 | TIGRFAM: siroheme synthase; PFAM: TrkA-N domain protein. (252 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (441 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (380 aa) |
| | aroK | TIGRFAM: shikimate kinase; PFAM: GHMP kinase; GHMP kinase, C terminal domain protein. (272 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (129 aa) |
| | Igni_0566 | PFAM: aspartate/glutamate/uridylate kinase. (236 aa) |
| | Igni_0570 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase. (610 aa) |
| | Igni_0571 | TIGRFAM: UbiD family decarboxylase; PFAM: Carboxylyase-related protein. (489 aa) |
| | Igni_0580 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (313 aa) |
| | Igni_0600 | Amidophosphoribosyltransferase; PFAM: phosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (424 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (343 aa) |
| | lysZ | N2-acetyl-L-aminoadipate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (264 aa) |
| | Igni_0630 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (389 aa) |
| | argG | PFAM: argininosuccinate synthase; ExsB family protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (396 aa) |
| | Igni_0645 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. (547 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (245 aa) |
| | Igni_0678 | Fumarase; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region; Fe-S type hydro-lyase tartrate/fumarate beta region. (492 aa) |
| | hemL | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (423 aa) |
| | hemC | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (304 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (222 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (147 aa) |
| | lysY | N2-acetyl-L-aminoadipate semialdehyde dehydrogenase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (356 aa) |
| | metE | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. (341 aa) |
| | Igni_0748 | PFAM: Methionine synthase, vitamin-B12 independent; Cobalamin-independent synthase MetE, N-terminal domain protein. (332 aa) |
| | Igni_0752 | TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region. (359 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (283 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (321 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa) |
| | fni | Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (360 aa) |
| | Igni_0805 | PFAM: imidazoleglycerol-phosphate dehydratase. (189 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (235 aa) |
| | purS | Hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the am [...] (90 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (219 aa) |
| | Igni_0859 | PFAM: aminotransferase, class I and II. (404 aa) |
| | Igni_0868 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (364 aa) |
| | Igni_0871 | PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase, GAPDH domain protein. (387 aa) |
| | Igni_0873 | Nucleotidyl transferase; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; transferase hexapeptide repeat containing protein; Nucleotidyl transferase. (416 aa) |
| | mqnD | Protein of unknown function DUF191; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (271 aa) |
| | Igni_0885 | PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; Belongs to the phosphohexose mutase family. (456 aa) |
| | Igni_0891 | Transketolase subunit B; PFAM: Transketolase, central region; Transketolase domain protein. (316 aa) |
| | Igni_0892 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; 6-phosphogluconate dehydrogenase, NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein. (348 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (432 aa) |
| | Igni_0925 | PFAM: Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein. (401 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (194 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (139 aa) |
| | Igni_0943 | PFAM: IMP biosynthesis enzyme PurP-like. (366 aa) |
| | lysJ | N2-acetyl-L-lysine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (386 aa) |
| | Igni_0957 | Hypothetical protein. (185 aa) |
| | ilvD | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (552 aa) |
| | sat | TIGRFAM: sulfate adenylyltransferase; PFAM: ATP-sulfurylase; Belongs to the sulfate adenylyltransferase family. (382 aa) |
| | Igni_0982 | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (343 aa) |
| | leuA | Isopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). (399 aa) |
| | Igni_0986 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. (240 aa) |
| | gap | TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: glyceraldehyde 3-phosphate dehydrogenase; dihydrodipicolinate reductase. (352 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (414 aa) |
| | Igni_1034 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (408 aa) |
| | Igni_1036 | PFAM: short-chain dehydrogenase/reductase SDR. (261 aa) |
| | ribL | Cytidyltransferase-related domain protein; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (226 aa) |
| | Igni_1064 | TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase. (419 aa) |
| | Igni_1075 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (82 aa) |
| | Igni_1076 | 2-oxoglutarate ferredoxin oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase. (175 aa) |
| | Igni_1077 | 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding. (288 aa) |
| | Igni_1078 | 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein. (360 aa) |
| | Igni_1086 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (351 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (429 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa) |
| | Igni_1097 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein. (577 aa) |
| | Igni_1098 | Hypothetical protein. (99 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (426 aa) |
| | Igni_1102 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. (387 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (562 aa) |
| | Igni_1113 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (821 aa) |
| | Igni_1159 | PFAM: Nucleotidyl transferase. (232 aa) |
| | Igni_1168 | PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (327 aa) |
| | Igni_1189 | PFAM: Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein. (377 aa) |
| | adkA | Adenylate kinase-like protein; Belongs to the archaeal adenylate kinase family. (202 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (301 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (175 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (713 aa) |
| | Igni_1256 | TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase. (189 aa) |
| | Igni_1257 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (102 aa) |
| | Igni_1258 | Pyruvate ferredoxin oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (396 aa) |
| | Igni_1259 | Pyruvate ferredoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding. (322 aa) |
| | Igni_1263 | PFAM: Lactate/malate dehydrogenase; Belongs to the LDH/MDH superfamily. (311 aa) |
| | Igni_1267 | PFAM: Transketolase domain protein. (279 aa) |
| | Igni_1284 | SPP-like hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate. (248 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (443 aa) |
| | Igni_1329 | PFAM: Indole-3-glycerol phosphate synthase. (254 aa) |
| | Igni_1333 | Histidinol phosphate aminotransferase; PFAM: aminotransferase, class I and II. (355 aa) |
| | Igni_1334 | TIGRFAM: riboflavin synthase. (148 aa) |
| | Igni_1361 | Glucokinase; PFAM: ROK family protein. (303 aa) |
| | apgM | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (416 aa) |
| | arcB | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (311 aa) |
| | Igni_1401 | TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase. (396 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (402 aa) |
| | Igni_1430 | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase. (452 aa) |
| | Igni_1436 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA. (332 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
