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C5YZX1_SORBI C5YZX1_SORBI C5YW21_SORBI C5YW21_SORBI C5YUG3_SORBI C5YUG3_SORBI C5YQ06_SORBI C5YQ06_SORBI C5YLQ3_SORBI C5YLQ3_SORBI C5YD28_SORBI C5YD28_SORBI C5YB10_SORBI C5YB10_SORBI C5Y949_SORBI C5Y949_SORBI NNRD_SORBI NNRD_SORBI C5Y093_SORBI C5Y093_SORBI C5XX52_SORBI C5XX52_SORBI C5XVU9_SORBI C5XVU9_SORBI C5XVU3_SORBI C5XVU3_SORBI C5XRJ7_SORBI C5XRJ7_SORBI C5XRJ6_SORBI C5XRJ6_SORBI THI1-1 THI1-1 C5XND6_SORBI C5XND6_SORBI C5XN69_SORBI C5XN69_SORBI C5XMH4_SORBI C5XMH4_SORBI C5XME6_SORBI C5XME6_SORBI C5XJX0_SORBI C5XJX0_SORBI C5XJW6_SORBI C5XJW6_SORBI C5XJD7_SORBI C5XJD7_SORBI C5XIY9_SORBI C5XIY9_SORBI C5XIC9_SORBI C5XIC9_SORBI C5XHQ9_SORBI C5XHQ9_SORBI C5XH34_SORBI C5XH34_SORBI C5XDG4_SORBI C5XDG4_SORBI C5X9S7_SORBI C5X9S7_SORBI C5X9F2_SORBI C5X9F2_SORBI C5X4A1_SORBI C5X4A1_SORBI THI1-2 THI1-2 C5WZT3_SORBI C5WZT3_SORBI C5WZ26_SORBI C5WZ26_SORBI C5WYF2_SORBI C5WYF2_SORBI C5WWX0_SORBI C5WWX0_SORBI C5WTM9_SORBI C5WTM9_SORBI ndhH ndhH ndhA ndhA ndhI ndhI ndhG ndhG ndhE ndhE ndhD ndhD ndhC ndhC ndhK ndhK ndhJ ndhJ A0A1Z5S4N8 A0A1Z5S4N8 A0A1Z5R9Q9 A0A1Z5R9Q9 A0A1Z5R1U0 A0A1Z5R1U0 A0A1W0VXQ9 A0A1W0VXQ9 A0A1B6QJH1 A0A1B6QJH1 A0A1B6QHY1 A0A1B6QHY1 A0A1B6QHH2 A0A1B6QHH2 A0A1B6QFX4 A0A1B6QFX4 A0A1B6QDQ0 A0A1B6QDQ0 A0A1B6QAL7 A0A1B6QAL7 A0A1B6Q3D8 A0A1B6Q3D8 A0A1B6PRP0 A0A1B6PRP0 A0A1B6PRJ3 A0A1B6PRJ3 A0A1B6PMH4 A0A1B6PMH4 A0A1B6PF49 A0A1B6PF49 A0A1B6PBP5 A0A1B6PBP5 A0A1B6P664 A0A1B6P664 A0A194YU12 A0A194YU12 A0A194YQ61 A0A194YQ61 A0A194YMX1 A0A194YMX1 A0A194YMM6 A0A194YMM6 A0A194YI93 A0A194YI93 Nad6 Nad6 SORBI_3K044300 SORBI_3K044300 ndhF ndhF ndhB2 ndhB2 ndhB1 ndhB1 C5Z776_SORBI C5Z776_SORBI C5Z2Z6_SORBI C5Z2Z6_SORBI C5Z0N4_SORBI C5Z0N4_SORBI C5Z0L0_SORBI C5Z0L0_SORBI C5Z0B1_SORBI C5Z0B1_SORBI
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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C5YZX1_SORBINADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (279 aa)
C5YW21_SORBIMalate dehydrogenase. (340 aa)
C5YUG3_SORBIOxidored_q6 domain-containing protein; Belongs to the complex I 20 kDa subunit family. (202 aa)
C5YQ06_SORBIPoly [ADP-ribose] polymerase. (904 aa)
C5YLQ3_SORBID-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (619 aa)
C5YD28_SORBIGlutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (411 aa)
C5YB10_SORBI3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (407 aa)
C5Y949_SORBID-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (620 aa)
NNRD_SORBIATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (381 aa)
C5Y093_SORBIFormate dehydrogenase, mitochondrial; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Involved in the cell stress response; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (384 aa)
C5XX52_SORBIGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa)
C5XVU9_SORBIS-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (381 aa)
C5XVU3_SORBINicotinamide-nucleotide adenylyltransferase. (251 aa)
C5XRJ7_SORBIL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (357 aa)
C5XRJ6_SORBIL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
THI1-1Thiamine thiazole synthase 1, chloroplastic; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; [...] (354 aa)
C5XND6_SORBINADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (311 aa)
C5XN69_SORBINADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (279 aa)
C5XMH4_SORBIGlycerol-3-phosphate dehydrogenase [NAD(+)]. (464 aa)
C5XME6_SORBIUncharacterized protein. (299 aa)
C5XJX0_SORBIPoly [ADP-ribose] polymerase. (496 aa)
C5XJW6_SORBIPoly [ADP-ribose] polymerase. (658 aa)
C5XJD7_SORBIGlycerol-3-phosphate dehydrogenase [NAD(+)]. (365 aa)
C5XIY9_SORBIDihydrolipoyl dehydrogenase. (504 aa)
C5XIC9_SORBIOxidored_q6 domain-containing protein; Belongs to the complex I 20 kDa subunit family. (200 aa)
C5XHQ9_SORBIGlycerol-3-phosphate dehydrogenase [NAD(+)]. (458 aa)
C5XH34_SORBINADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (74 aa)
C5XDG4_SORBIGlycerol-3-phosphate dehydrogenase [NAD(+)]. (430 aa)
C5X9S7_SORBIUDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (366 aa)
C5X9F2_SORBIInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (494 aa)
C5X4A1_SORBIGlutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (732 aa)
THI1-2Thiamine thiazole synthase 2, chloroplastic; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; [...] (352 aa)
C5WZT3_SORBIUDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (355 aa)
C5WZ26_SORBIInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (501 aa)
C5WYF2_SORBIMalate dehydrogenase. (332 aa)
C5WWX0_SORBIGlutathione reductase; Maintains high levels of reduced glutathione. (550 aa)
C5WTM9_SORBIUDP-glucose 6-dehydrogenase. (480 aa)
ndhHNAD(P)H-quinone oxidoreductase subunit H, chloroplastic; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. (393 aa)
ndhANAD(P)H-quinone oxidoreductase subunit 1, chloroplastic; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. (362 aa)
ndhINAD(P)H-quinone oxidoreductase subunit I, chloroplastic; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Belongs to the complex I 23 kDa subunit family. (180 aa)
ndhGNAD(P)H-quinone oxidoreductase subunit 6, chloroplastic; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity). (176 aa)
ndhENAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. (101 aa)
ndhDNAD(P)H-quinone oxidoreductase chain 4, chloroplastic. (500 aa)
ndhCNAD(P)H-quinone oxidoreductase subunit 3, chloroplastic; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. (120 aa)
ndhKNAD(P)H-quinone oxidoreductase subunit K, chloroplastic; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Belongs to the complex I 20 kDa subunit family. (227 aa)
ndhJNAD(P)H-quinone oxidoreductase subunit J, chloroplastic; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. (159 aa)
A0A1Z5S4N8Histidinol dehydrogenase, chloroplastic; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (478 aa)
A0A1Z5R9Q9Malate dehydrogenase. (394 aa)
A0A1Z5R1U0Uncharacterized protein; Belongs to the complex I subunit 6 family. (304 aa)
A0A1W0VXQ9NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (70 aa)
A0A1B6QJH1UDP-glucose 6-dehydrogenase. (499 aa)
A0A1B6QHY1UDP-glucose 6-dehydrogenase. (480 aa)
A0A1B6QHH2Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (411 aa)
A0A1B6QFX4NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (499 aa)
A0A1B6QDQ0UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (364 aa)
A0A1B6QAL7Poly [ADP-ribose] polymerase. (979 aa)
A0A1B6Q3D8Uncharacterized protein. (561 aa)
A0A1B6PRP0Adenosylhomocysteinase. (485 aa)
A0A1B6PRJ3ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (397 aa)
A0A1B6PMH4Malate dehydrogenase. (354 aa)
A0A1B6PF49Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa)
A0A1B6PBP5NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (391 aa)
A0A1B6P664Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa)
A0A194YU12Glutathione reductase; Maintains high levels of reduced glutathione. (495 aa)
A0A194YQ61Poly [ADP-ribose] polymerase. (834 aa)
A0A194YMX1Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (527 aa)
A0A194YMM6Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa)
A0A194YI93Uncharacterized protein; Belongs to the complex I subunit 6 family. (139 aa)
Nad6Uncharacterized protein; Belongs to the complex I subunit 6 family. (224 aa)
SORBI_3K044300Poly [ADP-ribose] polymerase. (157 aa)
ndhFNAD(P)H-quinone oxidoreductase subunit 5, chloroplastic; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity). (738 aa)
ndhB2NAD(P)H-quinone oxidoreductase subunit 2 B, chloroplastic; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. (510 aa)
ndhB1NAD(P)H-quinone oxidoreductase subunit 2 A, chloroplastic; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. (510 aa)
C5Z776_SORBID-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (613 aa)
C5Z2Z6_SORBIFormate dehydrogenase, mitochondrial; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Involved in the cell stress response; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (376 aa)
C5Z0N4_SORBIDihydrolipoyl dehydrogenase. (500 aa)
C5Z0L0_SORBIDihydrolipoyl dehydrogenase. (562 aa)
C5Z0B1_SORBIGlycerol-3-phosphate dehydrogenase [NAD(+)]. (461 aa)
Your Current Organism:
Sorghum bicolor
NCBI taxonomy Id: 4558
Other names: Andropogon sorghum, Andropogon sorghum (L.) Brot., S. bicolor, Sorghum bicolor (L.) Moench, Sorghum bicolor subsp. bicolor, Sorghum nervosum, Sorghum nervosum Besser ex Schult., Sorghum saccharatum, Sorghum saccharatum (L.) Moench, Sorghum vulgare, Sorghum vulgare Pers., broomcorn, milo, sorghum
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