(50 nodes) Ubiquinone and other terpenoid-quinone biosynthesis network (Sorghum bicolor)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A194YKI4	Uncharacterized protein. (393 aa)
	A0A194YRW3	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family. (356 aa)
	A0A1B6P9F4	Flavodoxin-like domain-containing protein. (204 aa)
	A0A1B6PBR1	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family. (339 aa)
	A0A1B6PEA9	SAM_MPBQ_MSBQ_MT domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. MPBQ/MBSQ MT family. (306 aa)
	A0A1B6PSM5	Aminotran_1_2 domain-containing protein. (438 aa)
	COQ5	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (298 aa)
	A0A1B6Q6I7	Flavodoxin-like domain-containing protein. (203 aa)
	A0A1B6Q9S9	Flavodoxin-like domain-containing protein. (276 aa)
	A0A1B6QKM3	Flavodoxin-like domain-containing protein. (255 aa)
	A0A1B6QLK8	Uncharacterized protein. (573 aa)
	A0A1B6QQ07	Uncharacterized protein. (361 aa)
	A0A1B6QQG1	Uncharacterized protein. (553 aa)
	A0A1W0VRZ3	Uncharacterized protein. (854 aa)
	A0A1W0VY74	Aminotran_1_2 domain-containing protein. (428 aa)
	A0A1W0W700	Uncharacterized protein. (382 aa)
	MENG	2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplastic; Involved in the biosynthesis of phylloquinone (vitamin K1). Methyltransferase required for the conversion of 2-phytyl-1,4-beta- naphthoquinol to phylloquinol. (276 aa)
	A0A1Z5RJK9	Aminotran_1_2 domain-containing protein. (466 aa)
	A0A1Z5RJT9	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family. (303 aa)
	A0A1Z5RN43	Flavodoxin-like domain-containing protein. (218 aa)
	A0A1Z5RNE1	MR_MLE domain-containing protein. (1703 aa)
	A0A1Z5S5G9	4HBT domain-containing protein. (238 aa)
	A0A1Z5S6P3	Uncharacterized protein. (557 aa)
	COQ6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (515 aa)
	C5X3I2_SORBI	Uncharacterized protein. (496 aa)
	C5X760_SORBI	Flavodoxin-like domain-containing protein. (216 aa)
	C5XAN2_SORBI	Chorismate_bind domain-containing protein. (569 aa)
	C5XFF3_SORBI	Uncharacterized protein. (555 aa)
	C5XJK6_SORBI	Uncharacterized protein. (605 aa)
	C5XN98_SORBI	Uncharacterized protein; Belongs to the cytochrome P450 family. (505 aa)
	C5XUS0_SORBI	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (338 aa)
	C5XVJ3_SORBI	4-hydroxyphenylpyruvate dioxygenase. (440 aa)
	C5XW95_SORBI	Uncharacterized protein. (555 aa)
	C5XX86_SORBI	TRAF-type domain-containing protein. (351 aa)
	C5Y019_SORBI	Uncharacterized protein. (475 aa)
	C5Y0F9_SORBI	Uncharacterized protein. (566 aa)
	C5Y145_SORBI	Uncharacterized protein; Belongs to the cytochrome P450 family. (530 aa)
	C5Y4D8_SORBI	Aminotran_1_2 domain-containing protein. (442 aa)
	C5Y4D9_SORBI	Aminotran_1_2 domain-containing protein. (430 aa)
	C5YJI8_SORBI	Uncharacterized protein. (571 aa)
	C5YLR0_SORBI	Uncharacterized protein. (552 aa)
	C5YMX5_SORBI	Uncharacterized protein. (557 aa)
	C5YS19_SORBI	SAM_MPBQ_MSBQ_MT domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. MPBQ/MBSQ MT family. (349 aa)
	C5YT27_SORBI	4HBT domain-containing protein. (174 aa)
	C5YZK8_SORBI	4HBT domain-containing protein. (166 aa)
	C5YZK9_SORBI	4HBT domain-containing protein. (186 aa)
	COQ3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (324 aa)
	C5Z783_SORBI	Uncharacterized protein. (557 aa)
	C5Z789_SORBI	Uncharacterized protein. (400 aa)
	C4H	Cinnamic acid 4-hydroxylase; Belongs to the cytochrome P450 family. (501 aa)

Your Current Organism:

Sorghum bicolor

NCBI taxonomy Id: 4558
Other names: Andropogon sorghum, Andropogon sorghum (L.) Brot., S. bicolor, Sorghum bicolor (L.) Moench, Sorghum bicolor subsp. bicolor, Sorghum nervosum, Sorghum nervosum Besser ex Schult., Sorghum saccharatum, Sorghum saccharatum (L.) Moench, Sorghum vulgare, Sorghum vulgare Pers., broomcorn, milo, sorghum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A194YKI4	A0A1B6PEA9	A0A194YKI4	A0A1B6PEA9	Uncharacterized protein.	SAM_MPBQ_MSBQ_MT domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. MPBQ/MBSQ MT family.	0.937
A0A194YKI4	A0A1B6QQ07	A0A194YKI4	A0A1B6QQ07	Uncharacterized protein.	Uncharacterized protein.	0.812
A0A194YKI4	A0A1W0W700	A0A194YKI4	A0A1W0W700	Uncharacterized protein.	Uncharacterized protein.	0.910
A0A194YKI4	C5X3I2_SORBI	A0A194YKI4	C5X3I2	Uncharacterized protein.	Uncharacterized protein.	0.965
A0A194YKI4	C5XVJ3_SORBI	A0A194YKI4	C5XVJ3	Uncharacterized protein.	4-hydroxyphenylpyruvate dioxygenase.	0.965
A0A194YKI4	C5XX86_SORBI	A0A194YKI4	C5XX86	Uncharacterized protein.	TRAF-type domain-containing protein.	0.900
A0A194YKI4	C5Y019_SORBI	A0A194YKI4	C5Y019	Uncharacterized protein.	Uncharacterized protein.	0.957
A0A194YKI4	C5YS19_SORBI	A0A194YKI4	C5YS19	Uncharacterized protein.	SAM_MPBQ_MSBQ_MT domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. MPBQ/MBSQ MT family.	0.937
A0A194YKI4	C5Z789_SORBI	A0A194YKI4	C5Z789	Uncharacterized protein.	Uncharacterized protein.	0.903
A0A194YKI4	COQ3	A0A194YKI4	C5Z4B7	Uncharacterized protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.505
A0A194YKI4	COQ6	A0A194YKI4	C5WT36	Uncharacterized protein.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.453
A0A194YRW3	A0A1B6PBR1	A0A194YRW3	A0A1B6PBR1	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.	0.901
A0A194YRW3	A0A1Z5RJT9	A0A194YRW3	A0A1Z5RJT9	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.	0.901
A0A194YRW3	C5Y019_SORBI	A0A194YRW3	C5Y019	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.	Uncharacterized protein.	0.965
A0A194YRW3	C5Z789_SORBI	A0A194YRW3	C5Z789	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.	Uncharacterized protein.	0.411
A0A1B6P9F4	MENG	A0A1B6P9F4	A0A1Z5RDY7	Flavodoxin-like domain-containing protein.	2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplastic; Involved in the biosynthesis of phylloquinone (vitamin K1). Methyltransferase required for the conversion of 2-phytyl-1,4-beta- naphthoquinol to phylloquinol.	0.900
A0A1B6PBR1	A0A194YRW3	A0A1B6PBR1	A0A194YRW3	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.	0.901
A0A1B6PBR1	A0A1Z5RJT9	A0A1B6PBR1	A0A1Z5RJT9	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.	0.901
A0A1B6PBR1	C5Y019_SORBI	A0A1B6PBR1	C5Y019	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.	Uncharacterized protein.	0.965
A0A1B6PBR1	C5Z789_SORBI	A0A1B6PBR1	C5Z789	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.	Uncharacterized protein.	0.411

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