(45 nodes) Valine, leucine and isoleucine degradation network (Sorghum bicolor)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	A0A194YIH8	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (556 aa)
	A0A194YK00	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (427 aa)
	A0A194YT53	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (463 aa)
	A0A1B6PCB8	E1_dh domain-containing protein. (506 aa)
	A0A1B6PEL7	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
	A0A1B6PMJ9	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (553 aa)
	A0A1B6PQI9	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (478 aa)
	A0A1B6PU31	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (387 aa)
	A0A1B6Q2G4	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (421 aa)
	A0A1B6Q2V2	Pyruvate carboxyltransferase domain-containing protein. (438 aa)
	A0A1B6Q3D8	Uncharacterized protein. (561 aa)
	A0A1B6QDN8	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (470 aa)
	A0A1B6QM25	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (443 aa)
	A0A1B6QMR1	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
	A0A1B6QQ80	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (479 aa)
	A0A1B6QR82	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (404 aa)
	A0A1W0VZE1	Uncharacterized protein. (386 aa)
	A0A1W0VZQ2	Uncharacterized protein. (633 aa)
	A0A1W0W7X0	Uncharacterized protein. (836 aa)
	A0A1Z5R7X6	Uncharacterized protein. (752 aa)
	A0A1Z5REV8	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (496 aa)
	A0A1Z5RJZ9	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (410 aa)
	A0A1Z5SAL0	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (417 aa)
	A0A1Z5SBR4	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (464 aa)
	C5WMF3_SORBI	Uncharacterized protein. (268 aa)
	C5WRC8_SORBI	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
	C5WSJ3_SORBI	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (406 aa)
	C5WZG9_SORBI	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (462 aa)
	C5X0R5_SORBI	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (465 aa)
	C5XAC7_SORBI	Transket_pyr domain-containing protein. (369 aa)
	C5XBV0_SORBI	Aldedh domain-containing protein. (540 aa)
	C5XDP9_SORBI	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (509 aa)
	C5XIU9_SORBI	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (523 aa)
	C5XIY9_SORBI	Dihydrolipoyl dehydrogenase. (504 aa)
	C5XK53_SORBI	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (383 aa)
	C5XS04_SORBI	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (302 aa)
	C5XS38_SORBI	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (486 aa)
	C5Y433_SORBI	Pyruvate carboxyltransferase domain-containing protein. (384 aa)
	C5YH72_SORBI	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (471 aa)
	C5YL06_SORBI	Uncharacterized protein. (585 aa)
	C5YST8_SORBI	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (487 aa)
	C5YZR0_SORBI	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (479 aa)
	C5Z0L0_SORBI	Dihydrolipoyl dehydrogenase. (562 aa)
	C5Z0N4_SORBI	Dihydrolipoyl dehydrogenase. (500 aa)
	ALDH2a	Mitochondrial aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (551 aa)

Your Current Organism:

Sorghum bicolor

NCBI taxonomy Id: 4558
Other names: Andropogon sorghum, Andropogon sorghum (L.) Brot., S. bicolor, Sorghum bicolor (L.) Moench, Sorghum bicolor subsp. bicolor, Sorghum nervosum, Sorghum nervosum Besser ex Schult., Sorghum saccharatum, Sorghum saccharatum (L.) Moench, Sorghum vulgare, Sorghum vulgare Pers., broomcorn, milo, sorghum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A194YIH8	A0A194YT53	A0A194YIH8	A0A194YT53	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.549
A0A194YIH8	A0A1B6PEL7	A0A194YIH8	A0A1B6PEL7	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.569
A0A194YIH8	A0A1B6Q2G4	A0A194YIH8	A0A1B6Q2G4	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.606
A0A194YIH8	A0A1B6Q2V2	A0A194YIH8	A0A1B6Q2V2	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Pyruvate carboxyltransferase domain-containing protein.	0.490
A0A194YIH8	A0A1B6Q3D8	A0A194YIH8	A0A1B6Q3D8	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein.	0.453
A0A194YIH8	A0A1B6QMR1	A0A194YIH8	A0A1B6QMR1	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.569
A0A194YIH8	A0A1B6QQ80	A0A194YIH8	A0A1B6QQ80	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.823
A0A194YIH8	A0A1W0VZE1	A0A194YIH8	A0A1W0VZE1	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein.	0.907
A0A194YIH8	A0A1W0VZQ2	A0A194YIH8	A0A1W0VZQ2	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein.	0.919
A0A194YIH8	C5WZG9_SORBI	A0A194YIH8	C5WZG9	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.549
A0A194YIH8	C5X0R5_SORBI	A0A194YIH8	C5X0R5	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.823
A0A194YIH8	C5XBV0_SORBI	A0A194YIH8	C5XBV0	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Aldedh domain-containing protein.	0.932
A0A194YIH8	C5XIU9_SORBI	A0A194YIH8	C5XIU9	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.877
A0A194YIH8	C5XIY9_SORBI	A0A194YIH8	C5XIY9	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Dihydrolipoyl dehydrogenase.	0.453
A0A194YIH8	C5Y433_SORBI	A0A194YIH8	C5Y433	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Pyruvate carboxyltransferase domain-containing protein.	0.490
A0A194YIH8	C5YZR0_SORBI	A0A194YIH8	C5YZR0	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.823
A0A194YIH8	C5Z0L0_SORBI	A0A194YIH8	C5Z0L0	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Dihydrolipoyl dehydrogenase.	0.453
A0A194YIH8	C5Z0N4_SORBI	A0A194YIH8	C5Z0N4	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Dihydrolipoyl dehydrogenase.	0.453
A0A194YK00	A0A194YT53	A0A194YK00	A0A194YT53	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.791
A0A194YK00	A0A1B6PEL7	A0A194YK00	A0A1B6PEL7	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.791

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