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| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (337 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (130 aa) |
| | Mboo_0056 | PFAM: aminotransferase, class I and II; KEGG: mhu:Mhun_2478 aminotransferase, class I and II. (379 aa) |
| | trpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (452 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (328 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (385 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (291 aa) |
| | Mboo_0074 | PFAM: Chorismate mutase; KEGG: nph:NP3980A chorismate mutase. (125 aa) |
| | Mboo_0087 | KEGG: mhu:Mhun_3054 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (465 aa) |
| | purM | KEGG: mhu:Mhun_3055 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (330 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (476 aa) |
| | Mboo_0104 | PFAM: Methionine synthase, vitamin-B12 independent; Cobalamin-independent synthase MetE, N-terminal domain protein; KEGG: mhu:Mhun_2447 methionine synthase, vitamin-B12 independent. (300 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (430 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (290 aa) |
| | Mboo_0168 | Aminotransferase, class I and II; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II; KEGG: sus:Acid_3616 aminotransferase, class I and II. (400 aa) |
| | Mboo_0183 | KEGG: mhu:Mhun_2545 orotidine 5'-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase. (215 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family. (265 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (388 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: mhu:Mhun_1789 N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (195 aa) |
| | Mboo_0225 | PFAM: Indole-3-glycerol phosphate synthase; KEGG: mhu:Mhun_1788 indole-3-glycerol-phosphate synthase. (251 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | Mboo_0227 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: mhu:Mhun_1786 glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase. (197 aa) |
| | trpE | Anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (515 aa) |
| | Mboo_0239 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa) |
| | Mboo_0420 | TIGRFAM: cysteine synthases; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mba:Mbar_A2422 cysteine synthase. (311 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (982 aa) |
| | Mboo_0473 | KEGG: mhu:Mhun_1062 phosphoribosylformylglycinamidine synthase I. (277 aa) |
| | thyA | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. (241 aa) |
| | Mboo_0627 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: cac:CAC2876 deoxycytidylate deaminase. (162 aa) |
| | Mboo_0639 | PFAM: N-formylglutamate amidohydrolase; KEGG: xcb:XC_2656 formylglutamate amidohydrolase. (279 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (276 aa) |
| | Mboo_0660 | KEGG: mhu:Mhun_0956 adenosylhomocysteinase; TIGRFAM: adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; Belongs to the adenosylhomocysteinase family. (408 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (150 aa) |
| | guaAA | GMP synthase, small subunit; Catalyzes the synthesis of GMP from XMP. (184 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: mhu:Mhun_0084 argininosuccinate lyase. (474 aa) |
| | gatD | glutamyl-tRNA(Gln) amidotransferase, subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (382 aa) |
| | gatE | Putative aspartyl-tRNA(Asn) amidotransferase, B subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (632 aa) |
| | pyrH | Uridylate kinase, putative; Catalyzes the reversible phosphorylation of UMP to UDP. (234 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; KEGG: mhu:Mhun_0114 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (354 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: mhu:Mhun_0115 carbamoyl-phosphate synthase, large subunit. (1053 aa) |
| | argG | PFAM: argininosuccinate synthase; ExsB family protein; KEGG: mhu:Mhun_0116 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (403 aa) |
| | argF | KEGG: mba:Mbar_A3512 ornithine carbamoyltransferase; TIGRFAM: ornithine carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain. (303 aa) |
| | purD | KEGG: mhu:Mhun_1112 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase. (427 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (167 aa) |
| | Mboo_0848 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: mhu:Mhun_0540 dihydroorotase, multifunctional complex type. (421 aa) |
| | Mboo_0855 | PFAM: asparagine synthase; KEGG: mhu:Mhun_1015 asparagine synthase. (334 aa) |
| | gatC | glutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (89 aa) |
| | gatA | glutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (434 aa) |
| | gatB | glutamyl-tRNA(Gln) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (482 aa) |
| | Mboo_0861 | TIGRFAM: RNA methyltransferase, TrmH family, group 1; PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: mhu:Mhun_1009 RNA methyltransferase TrmH, group 1. (261 aa) |
| | Mboo_0870 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; KEGG: mhu:Mhun_1973 nitrite and sulphite reductase 4Fe-4S region. (291 aa) |
| | surE | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (260 aa) |
| | katG | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (733 aa) |
| | mat | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (400 aa) |
| | hisG-2 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. (236 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: sth:STH2836 imidazoleglycerol-phosphate dehydratase. (192 aa) |
| | Mboo_1086 | PFAM: 5'-Nucleotidase domain protein; KEGG: mhu:Mhun_2724 5'-nucleotidase-like. (571 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (296 aa) |
| | pyrK | Oxidoreductase FAD/NAD(P)-binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (254 aa) |
| | Mboo_1118 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mhu:Mhun_0824 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (446 aa) |
| | Mboo_1200 | PFAM: aminotransferase, class I and II; KEGG: mhu:Mhun_0911 aminotransferase, class I and II. (371 aa) |
| | Mboo_1205 | KEGG: mhu:Mhun_3032 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. (525 aa) |
| | Mboo_1256 | PFAM: shikimate kinase; KEGG: mhu:Mhun_1850 shikimate kinase. (166 aa) |
| | Mboo_1263 | PFAM: PUA domain containing protein; phosphoadenosine phosphosulfate reductase; KEGG: mhu:Mhun_2578 uncharacterized domain 2. (464 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa) |
| | Mboo_1354 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding; KEGG: mhu:Mhun_2292 homoserine dehydrogenase. (328 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (313 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (255 aa) |
| | Mboo_1399 | TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region; KEGG: mhu:Mhun_1495 aspartate-semialdehyde dehydrogenase. (338 aa) |
| | Mboo_1475 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; KEGG: mhu:Mhun_1973 nitrite and sulphite reductase 4Fe-4S region. (301 aa) |
| | aroA | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (262 aa) |
| | aroA-2 | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (260 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (329 aa) |
| | Mboo_1560 | PFAM: Prephenate dehydrogenase; KEGG: mhu:Mhun_1033 prephenate dehydrogenase. (276 aa) |
| | Mboo_1561 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: mhu:Mhun_1032 prephenate dehydratase. (264 aa) |
| | aroA-3 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (421 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (462 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (328 aa) |
| | aroD | Dehydroquinase class I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (209 aa) |
| | Mboo_1658 | PFAM: PfkB domain protein; KEGG: mhu:Mhun_0077 PfkB; Belongs to the carbohydrate kinase PfkB family. (298 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa) |
| | tmk | dTMP kinase; PFAM: thymidylate kinase; KEGG: mhu:Mhun_2629 thymidylate kinase. (206 aa) |
| | hisS | KEGG: mhu:Mhun_2918 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S); Anticodon-binding domain protein; Belongs to the class-II aminoacyl-tRNA synthetase family. (410 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (165 aa) |
| | Mboo_1890 | TIGRFAM: phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein; KEGG: mhu:Mhun_3012 phosphoribosylglycinamide formyltransferase. (213 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (123 aa) |
| | Mboo_1982 | KEGG: mac:MA2721 serine O-acetyltransferase / hypothetical protein (multi-domain); TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; protein of unknown function DUF59. (320 aa) |
| | Mboo_1983 | TIGRFAM: cysteine synthases; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mba:Mbar_A2422 cysteine synthase. (309 aa) |
| | Mboo_1990 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ava:Ava_4156 cystathionine beta-synthase. (326 aa) |
| | Mboo_1991 | Cystathionine gamma-lyase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: cystathionine gamma-lyase. (386 aa) |
| | cysS | KEGG: mhu:Mhun_2176 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (419 aa) |
| | Mboo_1994 | KEGG: mhu:Mhun_2181 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; DegT/DnrJ/EryC1/StrS aminotransferase. (467 aa) |
| | Mboo_1995 | PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: sil:SPO0413 Cys/Met metabolism PLP-dependent enzyme family protein. (403 aa) |
| | Mboo_1996 | PFAM: aminotransferase, class I and II; KEGG: sus:Acid_3616 aminotransferase, class I and II. (379 aa) |
| | Mboo_2031 | TIGRFAM: aspartate racemase; PFAM: Asp/Glu racemase; KEGG: eca:ECA1293 putative aspartate/glutamate racemase. (240 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (491 aa) |
| | Mboo_2044 | KEGG: mhu:Mhun_2181 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; DegT/DnrJ/EryC1/StrS aminotransferase. (431 aa) |
| | hisE | PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mhu:Mhun_0790 phosphoribosyl-ATP pyrophosphohydrolase. (104 aa) |
| | Mboo_2096 | PFAM: aminotransferase, class I and II; KEGG: mhu:Mhun_2943 aminotransferase, class I and II. (382 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa) |
| | hisC | PFAM: aminotransferase, class I and II; KEGG: mhu:Mhun_2525 histidinol-phosphate aminotransferase. (351 aa) |
| | Mboo_2138 | TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aminotransferase class-III; KEGG: mhu:Mhun_2526 acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (383 aa) |
| | guaAB | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (305 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa) |
| | mfnA | Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (365 aa) |
| | hpt | Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (182 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (278 aa) |
| | purC | KEGG: mhu:Mhun_1253 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (256 aa) |
| | Mboo_2310 | PFAM: PHP C-terminal domain protein; SMART: phosphoesterase PHP domain protein; KEGG: mhu:Mhun_2482 PHP-like. (217 aa) |
| | Mboo_2394 | PFAM: phosphoribosyltransferase; KEGG: mhu:Mhun_0973 phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (201 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (275 aa) |
| | Mboo_2442 | KEGG: pab:PAB1605 asparagine synthase (glutamine-hydrolysing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase. (607 aa) |
