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| | Mboo_2442 | KEGG: pab:PAB1605 asparagine synthase (glutamine-hydrolysing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase. (607 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (314 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (298 aa) |
| | pdxT | SNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (199 aa) |
| | Mboo_0010 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: mac:MA1708 uncharacterized Fe-S protein. (226 aa) |
| | Mboo_0034 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (806 aa) |
| | Mboo_0038 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mhu:Mhun_2410 hypothetical protein. (362 aa) |
| | Mboo_0040 | PFAM: Radical SAM domain protein; KEGG: mhu:Mhun_2970 hypothetical protein. (362 aa) |
| | Mboo_0044 | PFAM: thiamine biosynthesis protein ThiC; KEGG: mhu:Mhun_2459 thiamine biosynthesis protein ThiC. (425 aa) |
| | Mboo_0053 | PFAM: aminotransferase, class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mhu:Mhun_2475 serine--glyoxylate transaminase. (376 aa) |
| | Mboo_0054 | TIGRFAM: riboflavin synthase; PFAM: 6,7-dimethyl-8-ribityllumazine synthase; KEGG: mhu:Mhun_2476 riboflavin synthase. (153 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (139 aa) |
| | trpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (452 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (328 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (385 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (291 aa) |
| | Mboo_0074 | PFAM: Chorismate mutase; KEGG: nph:NP3980A chorismate mutase. (125 aa) |
| | Mboo_0087 | KEGG: mhu:Mhun_3054 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (465 aa) |
| | Mboo_0104 | PFAM: Methionine synthase, vitamin-B12 independent; Cobalamin-independent synthase MetE, N-terminal domain protein; KEGG: mhu:Mhun_2447 methionine synthase, vitamin-B12 independent. (300 aa) |
| | Mboo_0122 | TIGRFAM: UbiD family decarboxylases; PFAM: Carboxylyase-related protein; KEGG: mhu:Mhun_2438 carboxylyase-related protein. (413 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (290 aa) |
| | Mboo_0147 | KEGG: mba:Mbar_A3450 uncharacterized membrane protein. (216 aa) |
| | ribK | Protein of unknown function DUF120; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (222 aa) |
| | Mboo_0160 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (225 aa) |
| | Mboo_0176 | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: mhu:Mhun_1110 methyltransferase type 11. (279 aa) |
| | Mboo_0212 | PFAM: alpha-acetolactate decarboxylase; KEGG: mmp:MMP0613 alpha-acetolactate decarboxylase. (271 aa) |
| | cbiA | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (447 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family. (265 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (388 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: mhu:Mhun_1789 N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (195 aa) |
| | Mboo_0225 | PFAM: Indole-3-glycerol phosphate synthase; KEGG: mhu:Mhun_1788 indole-3-glycerol-phosphate synthase. (251 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | trpE | Anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (515 aa) |
| | Mboo_0251 | PFAM: transferase hexapeptide repeat containing protein; KEGG: mhu:Mhun_2143 transferase hexapeptide repeat. (202 aa) |
| | Mboo_0261 | PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: mbo:Mb2551c hypothetical protein. (467 aa) |
| | Mboo_0266 | KEGG: mhu:Mhun_2831 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. (137 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (202 aa) |
| | Mboo_0340 | PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding; KEGG: bca:BCE_0533 general stress protein 26. (137 aa) |
| | Mboo_0391 | Methyltransferase type 11; PFAM: UbiE/COQ5 methyltransferase; Methyltransferase type 11; Methyltransferase type 12; KEGG: pen:PSEEN2920 hypothetical protein. (278 aa) |
| | Mboo_0420 | TIGRFAM: cysteine synthases; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mba:Mbar_A2422 cysteine synthase. (311 aa) |
| | Mboo_0430 | KEGG: gme:Gmet_0807 4Fe-4S ferredoxin, iron-sulfur binding protein. (295 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa) |
| | Mboo_0485 | PFAM: beta-lactamase domain protein; KEGG: mhu:Mhun_2337 beta-lactamase-like. (240 aa) |
| | Mboo_0514 | uroporphyrinogen-III synthase-like protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (230 aa) |
| | Mboo_0598 | PFAM: pyruvate carboxyltransferase; KEGG: mhu:Mhun_1801 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (376 aa) |
| | Mboo_0599 | KEGG: mhu:Mhun_1800 3-isopropylmalate dehydratase; TIGRFAM: homoaconitate hydratase family protein; 3-isopropylmalate dehydratase; PFAM: aconitate hydratase domain protein. (403 aa) |
| | Mboo_0600 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: mhu:Mhun_1799 3-isopropylmalate dehydratase, small subunit. (156 aa) |
| | Mboo_0602 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mhu:Mhun_1797 3-isopropylmalate dehydrogenase. (325 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (276 aa) |
| | Mboo_0683 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (401 aa) |
| | cobS | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (236 aa) |
| | Mboo_0703 | PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; KEGG: mhu:Mhun_1589 protein of unknown function DUF102; Belongs to the UPF0284 family. (342 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: mhu:Mhun_0084 argininosuccinate lyase. (474 aa) |
| | Mboo_0767 | PFAM: purine phosphorylase, family 2; KEGG: mhu:Mhun_1049 purine phosphorylase, family 2. (223 aa) |
| | Mboo_0804 | KEGG: mhu:Mhun_2575 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase; TIGRFAM: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase; PFAM: bifunctional deaminase-reductase domain protein. (226 aa) |
| | Mboo_0826 | PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: mhu:Mhun_1060 AIR synthase related protein. (441 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; KEGG: mhu:Mhun_0114 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (354 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: mhu:Mhun_0115 carbamoyl-phosphate synthase, large subunit. (1053 aa) |
| | argG | PFAM: argininosuccinate synthase; ExsB family protein; KEGG: mhu:Mhun_0116 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (403 aa) |
| | argF | KEGG: mba:Mbar_A3512 ornithine carbamoyltransferase; TIGRFAM: ornithine carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain. (303 aa) |
| | Mboo_0855 | PFAM: asparagine synthase; KEGG: mhu:Mhun_1015 asparagine synthase. (334 aa) |
| | Mboo_0880 | PFAM: beta-lactamase domain protein; KEGG: mac:MA1946 dihydropteroate synthase. (322 aa) |
| | Mboo_0908 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: mhu:Mhun_0807 5-amino-6-(5-phosphoribosylamino)uracil reductase. (226 aa) |
| | Mboo_0991 | PFAM: glutamine amidotransferase class-I; CobB/CobQ domain protein glutamine amidotransferase; KEGG: mtp:Mthe_1351 glutamine amidotransferase class-I. (186 aa) |
| | Mboo_1046 | PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: diaminopimelate decarboxylase. (397 aa) |
| | hisG-2 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. (236 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: sth:STH2836 imidazoleglycerol-phosphate dehydratase. (192 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (217 aa) |
| | Mboo_1115 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa) |
| | Mboo_1152 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: mac:MA0667 hypothetical protein. (354 aa) |
| | Mboo_1175 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: mma:MM2349 putative phosphatase. (241 aa) |
| | ilvD | KEGG: mhu:Mhun_0139 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (550 aa) |
| | Mboo_1223 | TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mhu:Mhun_3216 precorrin-6y C5,15-methyltransferase, subunit CbiE. (203 aa) |
| | cbiD | Cobalamin (vitamin B12) biosynthesis CbiD protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (334 aa) |
| | Mboo_1225 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: mhu:Mhun_3214 precorrin-8X methylmutase CbiC/CobH. (221 aa) |
| | Mboo_1226 | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mma:MM0995 precorrin-3B C17-methyltransferase. (260 aa) |
| | Mboo_1227 | PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: mhu:Mhun_3212 cobalamin (vitamin B12) biosynthesis CbiG protein. (290 aa) |
| | Mboo_1228 | PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mhu:Mhun_3211 precorrin-4 C11-methyltransferase. (248 aa) |
| | Mboo_1229 | PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mhu:Mhun_3210 uroporphyrin-III C/tetrapyrrole (corrin/porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family. (201 aa) |
| | Mboo_1230 | PFAM: Methyltransferase type 11; KEGG: mba:Mbar_A0625 precorrin-8W decarboxylase. (180 aa) |
| | Mboo_1256 | PFAM: shikimate kinase; KEGG: mhu:Mhun_1850 shikimate kinase. (166 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa) |
| | Mboo_1272 | PFAM: CBS domain containing protein; protein of unknown function DUF39; KEGG: mhu:Mhun_0138 protein of unknown function DUF39. (502 aa) |
| | Mboo_1273 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: mhu:Mhun_0137 4Fe-4S ferredoxin, iron-sulfur binding. (128 aa) |
| | cbiM | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (232 aa) |
| | cbiN | Cobalt transport protein CbiN; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (102 aa) |
| | Mboo_1354 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding; KEGG: mhu:Mhun_2292 homoserine dehydrogenase. (328 aa) |
| | Mboo_1388 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: mhu:Mhun_1484 peptidase M20. (393 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (313 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (255 aa) |
| | Mboo_1399 | TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region; KEGG: mhu:Mhun_1495 aspartate-semialdehyde dehydrogenase. (338 aa) |
| | Mboo_1403 | KEGG: mhu:Mhun_0943 putative phosphoserine phosphatase. (286 aa) |
| | Mboo_1407 | KEGG: mhu:Mhun_0939 5-deoxyadenosylcobinamide phosphate nucleotidyltransferase. (201 aa) |
| | Mboo_1417 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: mhu:Mhun_0668 cobalamin (vitamin B12) biosynthesis CbiX protein. (133 aa) |
| | cbiA-2 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (457 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (347 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | cimA | Isopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (496 aa) |
| | Mboo_1444 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mhu:Mhun_1241 acetolactate synthase, small subunit. (167 aa) |
| | gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (249 aa) |
| | aroA | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (262 aa) |
| | aroA-2 | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (260 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (329 aa) |
| | Mboo_1560 | PFAM: Prephenate dehydrogenase; KEGG: mhu:Mhun_1033 prephenate dehydrogenase. (276 aa) |
| | Mboo_1561 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: mhu:Mhun_1032 prephenate dehydratase. (264 aa) |
| | aroA-3 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (421 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (462 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (328 aa) |
| | Mboo_1569 | PFAM: beta-lactamase domain protein; KEGG: mac:MA1946 dihydropteroate synthase. (312 aa) |
| | aroD | Dehydroquinase class I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (209 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (229 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (425 aa) |
| | fbp | Fructose-bisphosphatase; PFAM: Inositol phosphatase/fructose-1,6-bisphosphatase; KEGG: mhu:Mhun_1206 inositol phosphatase/fructose-1,6-bisphosphatase. (300 aa) |
| | fbp-2 | Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa) |
| | Mboo_1626 | PFAM: RimK domain protein ATP-grasp; KEGG: mtp:Mthe_1695 RimK domain protein ATP-grasp. (290 aa) |
| | Mboo_1630 | PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: mma:MM3293 iron-sulfur cluster-binding protein. (268 aa) |
| | Mboo_1689 | KEGG: mhu:Mhun_0779 glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp. (441 aa) |
| | Mboo_1691 | Glutamate synthase (NADPH); PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein; ferredoxin-dependent glutamate synthase; KEGG: mhu:Mhun_0781 glutamate synthase (NADPH); Belongs to the glutamate synthase family. (503 aa) |
| | Mboo_1718 | PFAM: histidine biosynthesis; KEGG: mhu:Mhun_2630 histidine biosynthesis; Belongs to the HisA/HisF family. (238 aa) |
| | hisS | KEGG: mhu:Mhun_2918 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S); Anticodon-binding domain protein; Belongs to the class-II aminoacyl-tRNA synthetase family. (410 aa) |
| | Mboo_1740 | TIGRFAM: holo-acyl-carrier-protein synthase; PFAM: 4'-phosphopantetheinyl transferase; KEGG: mhu:Mhun_3109 phosphopantethiene--protein transferase domain. (151 aa) |
| | Mboo_1764 | UDP-glucose 6-dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; UDP-glucose/GDP-mannose dehydrogenase; KEGG: mhu:Mhun_3078 UDP-glucose 6-dehydrogenase. (425 aa) |
| | Mboo_1783 | TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp; KEGG: mhu:Mhun_3190 acetyl-CoA carboxylase, biotin carboxylase. (493 aa) |
| | Mboo_1815 | PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mhu:Mhun_2360 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (490 aa) |
| | Mboo_1840 | Putative translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (348 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (480 aa) |
| | gap | KEGG: mhu:Mhun_2462 glyceraldehyde-3-phosphate dehydrogenase, type II; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: glyceraldehyde 3-phosphate dehydrogenase; dihydrodipicolinate reductase. (343 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (123 aa) |
| | Mboo_1947 | KEGG: rso:RSp0886 probable glutamine synthetase protein; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp. (491 aa) |
| | Mboo_1982 | KEGG: mac:MA2721 serine O-acetyltransferase / hypothetical protein (multi-domain); TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; protein of unknown function DUF59. (320 aa) |
| | Mboo_1983 | TIGRFAM: cysteine synthases; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mba:Mbar_A2422 cysteine synthase. (309 aa) |
| | thiI | Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (213 aa) |
| | Mboo_1990 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ava:Ava_4156 cystathionine beta-synthase. (326 aa) |
| | Mboo_1994 | KEGG: mhu:Mhun_2181 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; DegT/DnrJ/EryC1/StrS aminotransferase. (467 aa) |
| | Mboo_2020 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: ath:At1g72190 oxidoreductase family protein. (325 aa) |
| | thiI-2 | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (370 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (491 aa) |
| | Mboo_2044 | KEGG: mhu:Mhun_2181 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; DegT/DnrJ/EryC1/StrS aminotransferase. (431 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (266 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (216 aa) |
| | uppS | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. (255 aa) |
| | Mboo_2065 | PFAM: Di-trans-poly-cis-decaprenylcistransferase; KEGG: mhu:Mhun_0786 di-trans-poly-cis-decaprenylcistransferase. (213 aa) |
| | hisE | PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mhu:Mhun_0790 phosphoribosyl-ATP pyrophosphohydrolase. (104 aa) |
| | leuC | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (165 aa) |
| | Mboo_2077 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mhu:Mhun_2363 3-isopropylmalate dehydrogenase. (371 aa) |
| | Mboo_2096 | PFAM: aminotransferase, class I and II; KEGG: mhu:Mhun_2943 aminotransferase, class I and II. (382 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa) |
| | Mboo_2116 | Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate. (424 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (302 aa) |
| | hisC | PFAM: aminotransferase, class I and II; KEGG: mhu:Mhun_2525 histidinol-phosphate aminotransferase. (351 aa) |
| | Mboo_2138 | TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aminotransferase class-III; KEGG: mhu:Mhun_2526 acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (383 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa) |
| | Mboo_2164 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: mhu:Mhun_3063 D-3-phosphoglycerate dehydrogenase. (534 aa) |
| | Mboo_2165 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (761 aa) |
| | hpt | Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (182 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (278 aa) |
| | cofG | Radical SAM domain protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (329 aa) |
| | purC | KEGG: mhu:Mhun_1253 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (256 aa) |
| | mptE | Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (208 aa) |
| | Mboo_2314 | PFAM: protein of unknown function DUF1271; SMART: zinc finger, CDGSH-type domain protein; KEGG: mba:Mbar_A3576 hypothetical protein. (232 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (286 aa) |
| | Mboo_2325 | PFAM: glucose-6-phosphate isomerase; KEGG: mhu:Mhun_2600 putative glucose-6-phosphate isomerase. (237 aa) |
| | Mboo_2426 | PFAM: transcriptional coactivator/pterin dehydratase; KEGG: rxy:Rxyl_2043 transcriptional coactivator/pterin dehydratase. (110 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (275 aa) |
