STRINGSTRING
ABZ96173.1 ABZ96173.1 kdsB kdsB lpxA lpxA lpxD2 lpxD2 ABZ97008.1 ABZ97008.1 lntA lntA ABZ97010.1 ABZ97010.1 ABZ97012.1 ABZ97012.1 ABZ97013.1 ABZ97013.1 lpxK lpxK ABZ97105.1 ABZ97105.1 ABZ97126.1 ABZ97126.1 ABZ97127.1 ABZ97127.1 ABZ97128.1 ABZ97128.1 ABZ97129.1 ABZ97129.1 ABZ97442.1 ABZ97442.1 exbB3 exbB3 exbD4 exbD4 ABZ97740.1 ABZ97740.1 pcrA1 pcrA1 ABZ97742.1 ABZ97742.1 cysQ cysQ ABZ97744.1 ABZ97744.1 kdsA kdsA lpxC lpxC ABZ98160.1 ABZ98160.1 ABZ98161.1 ABZ98161.1 ABZ98162.1 ABZ98162.1 ABZ98163.1 ABZ98163.1 lpxB lpxB lpxD lpxD ABZ99037.1 ABZ99037.1 ABZ99274.1 ABZ99274.1 ABZ99299.1 ABZ99299.1 suhB suhB ABZ99441.1 ABZ99441.1 ABZ99473.1 ABZ99473.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABZ96173.1Putative inositol monophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (280 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (246 aa)
lpxAAcyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (268 aa)
lpxD2UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (352 aa)
ABZ97008.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (98 aa)
lntAApolipoprotein N-acyltransferase 1 (ALP N-acyltransferase 1); Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (515 aa)
ABZ97010.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (349 aa)
ABZ97012.1Putative transcriptional regulator, TetR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (233 aa)
ABZ97013.1Hypothetical protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (561 aa)
lpxKPutative tetraacyldisaccharide 4'-kinase (Lipid A 4'-kinase); Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (374 aa)
ABZ97105.1Hypothetical protein; No homology to any previously reported sequences. (487 aa)
ABZ97126.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (349 aa)
ABZ97127.1Putative lipopolysaccharide core biosynthesis glycosyl transferase RfaQ; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (351 aa)
ABZ97128.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (207 aa)
ABZ97129.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (264 aa)
ABZ97442.1Putative 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa)
exbB3Biopolymer transport ExbB protein; Function of homologous gene experimentally demonstrated in an other organism; transporter. (204 aa)
exbD4Biopolymer transport ExbD protein; Function of homologous gene experimentally demonstrated in an other organism; transporter. (143 aa)
ABZ97740.1Putative outer membrane protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative membrane component. (958 aa)
pcrA1ATP-dependent DNA helicase PcrA; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (727 aa)
ABZ97742.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (142 aa)
cysQPAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; phenotype. (289 aa)
ABZ97744.1Putative glycosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (379 aa)
kdsAPhospho-2-dehydro-3-deoxyoctonate aldolase; 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase; KDO-8-phosphate synthetase; KDO 8-P synthase; (KDOPS; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. (281 aa)
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase); Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (302 aa)
ABZ98160.1Putative outer membrane efflux protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (513 aa)
ABZ98161.1Hypothetical protein; No homology to any previously reported sequences. (484 aa)
ABZ98162.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (76 aa)
ABZ98163.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (288 aa)
lpxBLipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (372 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (339 aa)
ABZ99037.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (250 aa)
ABZ99274.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (224 aa)
ABZ99299.1Putative lipid A biosynthesis lauroyl acyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (302 aa)
suhBInositol-1-monophosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the inositol monophosphatase superfamily. (271 aa)
ABZ99441.1Putative oxidoreductase, GFO/IDH/MOCA family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (320 aa)
ABZ99473.1Carbohydrate isomerase, KpsF/GutQ family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the SIS family. GutQ/KpsF subfamily. (324 aa)
Your Current Organism:
Leptospira biflexa
NCBI taxonomy Id: 456481
Other names: L. biflexa serovar Patoc strain 'Patoc 1 (Paris)', Leptospira biflexa serovar Patoc str. ATCC 23582, Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)', Leptospira biflexa serovar Patoc strain Patoc 1
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