STRINGSTRING
ABZ98574.1 ABZ98574.1 fabG4 fabG4 fabG3b fabG3b hom hom ABZ96252.1 ABZ96252.1 ABZ96253.1 ABZ96253.1 ABZ96260.1 ABZ96260.1 fabG2 fabG2 maeB maeB ABZ96296.1 ABZ96296.1 gmd gmd ABZ96337.1 ABZ96337.1 ABZ96345.1 ABZ96345.1 fabG1 fabG1 ABZ96372.1 ABZ96372.1 gpsA2 gpsA2 galE galE ABZ96677.1 ABZ96677.1 fadB2 fadB2 ABZ96757.1 ABZ96757.1 ABZ96819.1 ABZ96819.1 ilvC ilvC dapB dapB aroE aroE ugd ugd ABZ97191.1 ABZ97191.1 mdh mdh sirA sirA ABZ97311.1 ABZ97311.1 proC proC argC argC ABZ97651.1 ABZ97651.1 ABZ97652.1 ABZ97652.1 ABZ97654.1 ABZ97654.1 folD folD ABZ97858.1 ABZ97858.1 serA2 serA2 gpsA1 gpsA1 fabG3a fabG3a hldD hldD serA1 serA1 ABZ98127.1 ABZ98127.1 ABZ98139.1 ABZ98139.1 fcl fcl rmlB rmlB ABZ98151.1 ABZ98151.1 sucD sucD gap gap kefC kefC ABZ98372.1 ABZ98372.1 tyrA tyrA ABZ98546.1 ABZ98546.1 ABZ98564.1 ABZ98564.1 fabG fabG dxr dxr ABZ98720.1 ABZ98720.1 fabG5 fabG5 ABZ98773.1 ABZ98773.1 ABZ98829.1 ABZ98829.1 ABZ98837.1 ABZ98837.1 ABZ98938.1 ABZ98938.1 ABZ98951.1 ABZ98951.1 ABZ99038.1 ABZ99038.1 ABZ99064.1 ABZ99064.1 ABZ99119.1 ABZ99119.1 ABZ99181.1 ABZ99181.1 ABZ99183.1 ABZ99183.1 ABZ99244.1 ABZ99244.1 ABZ99252.1 ABZ99252.1 ABZ99297.1 ABZ99297.1 pntA pntA ABZ99320.1 ABZ99320.1 ABZ99326.1 ABZ99326.1 ABZ99339.1 ABZ99339.1 ABZ99354.1 ABZ99354.1 ABZ99358.1 ABZ99358.1 ABZ99384.1 ABZ99384.1 ABZ99439.1 ABZ99439.1 ABZ99441.1 ABZ99441.1 ABZ99656.1 ABZ99656.1 capD capD ahcY ahcY ABZ99731.1 ABZ99731.1 ABZ99732.1 ABZ99732.1 ABZ99744.1 ABZ99744.1 ABZ99745.1 ABZ99745.1 asd asd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABZ98574.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (276 aa)
fabG43-oxoacyl-[acyl-carrier-protein] reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (245 aa)
fabG3b3-ketoacyl-acyl carrier protein reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (255 aa)
homHomoserine dehydrogenase (HDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (427 aa)
ABZ96252.1Hypothetical protein; No homology to any previously reported sequences. (322 aa)
ABZ96253.1Putative short chain dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (276 aa)
ABZ96260.1Putative UDP-glucose 4-epimerase (UDP-galactose 4-epimerase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (321 aa)
fabG23-oxoacyl-[acyl-carrier-protein] reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (251 aa)
maeBNADP-dependent malic enzyme; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (433 aa)
ABZ96296.1Putative cation transporter, putative potassium ion transport TrkA-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (231 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (338 aa)
ABZ96337.1NADPH:quinone reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (332 aa)
ABZ96345.1Putative sodium/hydrogen exchanger; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (570 aa)
fabG13-oxoacyl-[acyl-carrier-protein] reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (255 aa)
ABZ96372.1Glycerol-3-phosphate dehydrogenase (NAD(P)(+)); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (806 aa)
gpsA2Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (333 aa)
galEUDP-glucose 4-epimerase (Galactowaldenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (322 aa)
ABZ96677.1Putative short-chain dehydrogenase, SDR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (250 aa)
fadB23-hydroxyacyl-CoA dehydrogenase, NAD binding FadB; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (436 aa)
ABZ96757.1Putative short-chain dehydrogenase, SDR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (235 aa)
ABZ96819.1Putative oxidoreductase, short-chain dehydrogenase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (257 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
dapBDihydrodipicolinate reductase (DHPR); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa)
aroEShikimate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (296 aa)
ugdUDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (434 aa)
ABZ97191.1Putative short chain dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (245 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (327 aa)
sirASiroheme synthetase, N-terminal domain protein; Includes: Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (197 aa)
ABZ97311.1Putative enoyl-(Acyl-carrier-protein) reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (278 aa)
proCPyrroline-5-carboxylate reductase (P5CR; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (247 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
ABZ97651.1Putative zinc-containing alcohol dehydrogenase superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (333 aa)
ABZ97652.1Putative short-chain dehydrogenase/reductase SDR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (267 aa)
ABZ97654.1Putative short-chain dehydrogenase/reductase SDR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (262 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa)
ABZ97858.1Putative glucose-fructose oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (346 aa)
serA2D-3-phosphoglycerate dehydrogenase (PGDH); Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (407 aa)
gpsA1Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (672 aa)
fabG3a3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (255 aa)
hldDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (323 aa)
serA1D-3-phosphoglycerate dehydrogenase (PGDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
ABZ98127.1Hypothetical protein; No homology to any previously reported sequences. (330 aa)
ABZ98139.1Putative UDP-glucose 4-epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (335 aa)
fclGDP-L-fucose synthetase (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase); Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (318 aa)
rmlBdTDP-glucose 4,6-dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (340 aa)
ABZ98151.1Putative short-chain dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (252 aa)
sucDSuccinyl-CoA synthetase alpha chain (SCS-alpha); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase (GAPDH; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
kefCK+ efflux antiporter, glutathione-regulated, NAD(P)-binding (CPA2 family); Function of homologous gene experimentally demonstrated in an other organism; transporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (605 aa)
ABZ98372.1Short-chain dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (506 aa)
tyrAPrephenate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (297 aa)
ABZ98546.1Putative thioredoxin-disulfide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (753 aa)
ABZ98564.1Putative alcohol dehydrogenase, zinc-containing; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (334 aa)
fabG3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase); Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (253 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase 2; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (386 aa)
ABZ98720.1Putative short chain dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (285 aa)
fabG53-oxoacyl-[acyl-carrier protein] reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (254 aa)
ABZ98773.1Putative NAD dependent epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (304 aa)
ABZ98829.1Putative dehydrogenase/reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (267 aa)
ABZ98837.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (136 aa)
ABZ98938.1Putative nucleoside-diphosphate-sugar epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (320 aa)
ABZ98951.1Putative short-chain dehydrogenase/reductase, SDR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (234 aa)
ABZ99038.1Putative Ser/thr kinase-related protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (230 aa)
ABZ99064.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (282 aa)
ABZ99119.1Putative L-threonine 3-dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (340 aa)
ABZ99181.1Putative NADPH:quinone reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (337 aa)
ABZ99183.1Putative alcohol dehydrogenase, zinc-containing alcohol dehydrogenase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (415 aa)
ABZ99244.1Putative dihydroflavonol-4-reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (358 aa)
ABZ99252.1Putative Zinc-dependent dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (339 aa)
ABZ99297.1Putative dTDP-glucose 4,6-dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (310 aa)
pntAPyridine nucleotide transhydrogenase subunit alpha 1; Nicotinamide nucleotide transhydrogenase subunit alpha 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (375 aa)
ABZ99320.1Putative short-chain dehydrogenase/reductase, SDR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa)
ABZ99326.1Putative epimerase/dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (306 aa)
ABZ99339.1Putative short-chain dehydrogenase/reductase, SDR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (257 aa)
ABZ99354.1Putative polyol dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (480 aa)
ABZ99358.1Putative zinc-binding alcohol dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (346 aa)
ABZ99384.1Putative short-chain dehydrogenases/reductase, SDR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (250 aa)
ABZ99439.1Hypothetical protein; No homology to any previously reported sequences. (228 aa)
ABZ99441.1Putative oxidoreductase, GFO/IDH/MOCA family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (320 aa)
ABZ99656.1Putative UDP-glucose 4-epimerase; Function of homologous gene experimentally demonstrated in an other organism; putative enzyme. (346 aa)
capDCapsular polysaccharide biosynthesis protein; Function of homologous gene experimentally demonstrated in an other organism; factor. (658 aa)
ahcYS-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (439 aa)
ABZ99731.1Putative short-chain dehydrogenase/reductase SDR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (245 aa)
ABZ99732.1Putative 3-oxoacyl-[acyl-carrier protein] reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (245 aa)
ABZ99744.1Putative 3-oxoacyl-[acyl-carrier protein] reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (269 aa)
ABZ99745.1Alcohol dehydrogenase (Zinc-containing alcohol dehydrogenase family); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (345 aa)
asdAspartate semialdehyde dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa)
Your Current Organism:
Leptospira biflexa
NCBI taxonomy Id: 456481
Other names: L. biflexa serovar Patoc strain 'Patoc 1 (Paris)', Leptospira biflexa serovar Patoc str. ATCC 23582, Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)', Leptospira biflexa serovar Patoc strain Patoc 1
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