STRINGSTRING
ANS85850.1 ANS85850.1 ANS85787.1 ANS85787.1 ANS85674.1 ANS85674.1 ANS85571.1 ANS85571.1 ANS85536.1 ANS85536.1 ANS85535.1 ANS85535.1 ANS85525.1 ANS85525.1 gdh2 gdh2 ANS85302.1 ANS85302.1 ANS85195.1 ANS85195.1 ANS85173.1 ANS85173.1 ANS85120.1 ANS85120.1 ANS84952.1 ANS84952.1 ANS84951.1 ANS84951.1 ANS84891.1 ANS84891.1 nth nth bamC bamC ANS84786.1 ANS84786.1 ushA ushA lolB lolB flgH flgH ANS84747.1 ANS84747.1 guaB guaB ANS84731.1 ANS84731.1 ANS84724.1 ANS84724.1 lptE lptE rlpA rlpA metN metN bamA bamA glnD glnD nqrE nqrE ANS84607.1 ANS84607.1 bamD bamD ANS84579.1 ANS84579.1 ANS84519.1 ANS84519.1 glxK glxK ANS84484.1 ANS84484.1 mrcB mrcB lptD lptD ANS84387.1 ANS84387.1 kdsD kdsD lptA lptA ANS84331.1 ANS84331.1 ANS84257.1 ANS84257.1 ANS84251.1 ANS84251.1 ANS84250.1 ANS84250.1 ANS84221.1 ANS84221.1 lpxM lpxM ANS84114.1 ANS84114.1 ANS84106.1 ANS84106.1 bamE bamE ANS86184.1 ANS86184.1 bamB bamB ANS86215.1 ANS86215.1 lpoA lpoA ANS86350.1 ANS86350.1 ANS86366.1 ANS86366.1 mazG mazG ANS86450.1 ANS86450.1 ANS86475.1 ANS86475.1 ANS86517.1 ANS86517.1 ANS86545.1 ANS86545.1 ANS86606.1 ANS86606.1 gen1 gen1 ANS86722.1 ANS86722.1 ANS86822.1 ANS86822.1 ANS86828.1 ANS86828.1 ANS86902.1 ANS86902.1 ANS87086.1 ANS87086.1 ANS87087.1 ANS87087.1 pldA pldA ANS87205.1 ANS87205.1 ANS87396.1 ANS87396.1 ANS87419.1 ANS87419.1 ANS87523.1 ANS87523.1 ANS87562.1 ANS87562.1 ANS87570.1 ANS87570.1 ANS87644.1 ANS87644.1 ANS87649.1 ANS87649.1 ANS87674.1 ANS87674.1 ANS87870.1 ANS87870.1 ANS87871.1 ANS87871.1 ANS87937.1 ANS87937.1 ANS87995.1 ANS87995.1 ANS87969.1 ANS87969.1 ANS88037.1 ANS88037.1 mltF mltF truA truA ANS85996.1 ANS85996.1 ANS85995.1 ANS85995.1 idh1 idh1 ANS85916.1 ANS85916.1 pal pal ANS85886.1 ANS85886.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANS85850.1Hypothetical protein. (329 aa)
ANS85787.1Hypothetical protein. (130 aa)
ANS85674.1Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family. (397 aa)
ANS85571.1Receptor for the bacteriocin pesticin and for the siderophore yersiniabactin; Belongs to the TonB-dependent receptor family. (702 aa)
ANS85536.1Hypothetical protein. (320 aa)
ANS85535.1Hypothetical protein. (383 aa)
ANS85525.1Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family. (397 aa)
gdh2Glutamate dehydrogenase; Involved in arginine catabolism by converting L- glutamate, into 2-oxoglutarate, which is then channeled into the tricarboxylic acid cycle. Can also utilize other amino acids of the glutamate family; Belongs to the Glu/Leu/Phe/Val dehydrogenases family; KEGG: vch:VC1492 glutamate dehydrogenase. (1613 aa)
ANS85302.1Hypothetical protein. (181 aa)
ANS85195.1Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family. (397 aa)
ANS85173.1Hypothetical protein. (441 aa)
ANS85120.1Penicillin-binding protein activator LpoB; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b); Belongs to the LpoB family. (196 aa)
ANS84952.1Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the host and is required for heme uptake. May be involved in virulence; Belongs to the TonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily. (322 aa)
ANS84951.1Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake. Belongs to the TonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily. (363 aa)
ANS84891.1Membrane-bound lytic murein transglycosylase. (324 aa)
nthDNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa)
bamCOuter membrane protein assembly factor BamC; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (340 aa)
ANS84786.1Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family. (397 aa)
ushA5'-nucleotidase; Degradation of extracellular 5'-nucleotides for nutritional needs. Belongs to the 5'-nucleotidase family; KEGG: vvu:VV1_0248 5'-nucleotidase / UDP-sugar diphosphatase. (553 aa)
lolBOuter-membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (205 aa)
flgHFlagellar L-ring protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (262 aa)
ANS84747.1Chitoporin; Involved in the uptake of chitosugars; Belongs to the Gram-negative porin family. (359 aa)
guaBIMP dehydrogenase; Contains 2 CBS domains; KEGG: bma:BMAA1350 IMP dehydrogenase. (135 aa)
ANS84731.1Protein Rcp; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (304 aa)
ANS84724.1Chitoporin; Involved in the uptake of chitosugars; Belongs to the Gram-negative porin family. (367 aa)
lptELPS-assembly lipoprotein LptE; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (220 aa)
rlpARlpA-like lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (278 aa)
metNLipoprotein-releasing system ATP-binding protein LolD; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (344 aa)
bamAOuter membrane protein assembly factor BamA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (800 aa)
glnD[Protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (874 aa)
nqrENa(+)-translocating NADH-quinone reductase subunit; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family. (199 aa)
ANS84607.1Outer membrane protein OmpK; Serves as receptor for a broad-host-range vibriophage, KVP40; To E. coli tsx. (280 aa)
bamDOuter membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (241 aa)
ANS84579.1Hypothetical protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. (478 aa)
ANS84519.1Outer membrane protein; Forms pores that allow passive diffusion of small molecules across the outer membrane; Belongs to the Gram-negative porin family. (353 aa)
glxKBelongs to the glycerate kinase type-1 family; KEGG: eco:b0514 glycerate kinase. (377 aa)
ANS84484.1Lysophospholipase NTE1; Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity); Belongs to the NTE family; Contains 2 cyclic nucleotide-binding domains; Contains 1 patatin domain. (760 aa)
mrcBPenicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (788 aa)
lptDLPS-assembly protein LptD; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (790 aa)
ANS84387.1Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; Belongs to the GSP D family. (546 aa)
kdsDArabinose-5-phosphate isomerase; Belongs to the SIS family. GutQ/KpsF subfamily; Contains 2 CBS domains; Contains 1 SIS domain; KEGG: vcy:IX92_01075 arabinose-5-phosphate isomerase. (321 aa)
lptALipopolysaccharide export system protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (165 aa)
ANS84331.1Hypothetical protein. (220 aa)
ANS84257.1Fimbrial assembly protein PilQ; Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane. Belongs to the GSP D family. (572 aa)
ANS84251.1Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family. (397 aa)
ANS84250.1Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family. (397 aa)
ANS84221.1Hypothetical protein. (885 aa)
lpxMLauroyl-Kdo(2)-lipid IV(A) myristoyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (330 aa)
ANS84114.1Type II secretion system protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (403 aa)
ANS84106.1Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane; Belongs to the GSP D family; overlaps another CDS with the same product name. (674 aa)
bamEOuter membrane protein assembly factor BamE; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (127 aa)
ANS86184.1Persistence and stress-resistance toxin PasT; Toxic component of a toxin-antitoxin (TA) module. Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes (By similarity). In this strain of E. coli low levels of PasT complement operon disruption, however high levels are toxi; their effects are abrogated by high level expression of cognate antitoxin PasI. Plays a role in persistence after antibiotic exposure and survival of nitrosative stres; the toxic and persistence phenotypes are conferred by the same N- terminal region of the protein, w [...] (147 aa)
bamBOuter membrane protein assembly factor BamB; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (386 aa)
ANS86215.1Membrane-bound lytic murein transglycosylase; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi (By similarity). (366 aa)
lpoAPenicillin-binding protein activator LpoA; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. (626 aa)
ANS86350.1Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells; Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family. (438 aa)
ANS86366.15'-nucleotidase; Involved in the biosynthesis of the compatible solute mannosylglucosylglycerate through a phosphorylating pathway. Catalyzes the dephosphorylation of mannosylglucosyl-3- phosphoglycerate (MGPG) to mannosylglucosylglycerate (MGG). Can also dephosphorylate UDP-glucose, ADP-glucose, GDP-mannose, glucosyl-3-phosphoglycerate (GPG), mannosyl-3-phosphoglycerate (MPG), ADP, GDP and UDP; Belongs to the 5'-nucleotidase family; KEGG: wvi:Weevi_2014 5'-nucleotidase. (519 aa)
mazGATP diphosphatase; Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazE-MazF toxin-antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA (By similarity); Belongs to the nucleoside triphosphate pyrophospho [...] (265 aa)
ANS86450.1Hypothetical protein. (200 aa)
ANS86475.1Hypothetical protein. (443 aa)
ANS86517.1Outer membrane antigenic lipoprotein; May be a virulence determinant. Belongs to the E. coli NlpD/Haemophilus LppB family; Contains 1 LysM repeat. (306 aa)
ANS86545.1Hypothetical protein. (812 aa)
ANS86606.1Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane; Belongs to the TamA family. (571 aa)
gen1Belongs to the UPF0047 family; KEGG: smm:Smp_169840 flap endonuclease GEN; Acting on ester bonds. (139 aa)
ANS86722.1Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1. B. 14. 3. 1) subfamily. (606 aa)
ANS86822.1Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family. (397 aa)
ANS86828.1Hypothetical protein. (380 aa)
ANS86902.1Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family. (397 aa)
ANS87086.1Hypothetical protein. (378 aa)
ANS87087.1Hypothetical protein. (309 aa)
pldAPhospholipase A(1); Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. (263 aa)
ANS87205.1Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family. (397 aa)
ANS87396.1Heme receptor; Belongs to the TonB-dependent receptor family. (638 aa)
ANS87419.1Maltoporin; Involved in the transport of maltose and maltodextrins; Belongs to the porin LamB (TC 1. B. 3) family. (445 aa)
ANS87523.1Outer membrane lipoprotein Blc; Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids. (218 aa)
ANS87562.1Hypothetical protein. (172 aa)
ANS87570.1Hypothetical protein. (326 aa)
ANS87644.1Hypothetical protein. (368 aa)
ANS87649.1Hypothetical protein. (808 aa)
ANS87674.1Heme transporter playing an important role in stationary-phase iron acquisition and required for maintenance of chronic infection in mice; Belongs to the TonB-dependent receptor family. (669 aa)
ANS87870.1Hypothetical protein. (150 aa)
ANS87871.1Receptor for the siderophore rhizobactin. Belongs to the TonB-dependent receptor family. (718 aa)
ANS87937.1Hypothetical protein. (348 aa)
ANS87995.1Hypothetical protein. (331 aa)
ANS87969.1Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family. (397 aa)
ANS88037.1Major outer membrane lipoprotein; Interacts with the peptidoglycan both covalently and noncovalently; Belongs to the Lpp family. (82 aa)
mltFMembrane-bound lytic murein transglycosylase; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (521 aa)
truAtRNA pseudouridine(38-40) synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (264 aa)
ANS85996.1Involved in translocation of long-chain fatty acids across the outer membrane. FadL may form a specific channel (By similarity); Belongs to the OmpP1/FadL family. (438 aa)
ANS85995.1Involved in translocation of long-chain fatty acids across the outer membrane. FadL may form a specific channel (By similarity); Belongs to the OmpP1/FadL family. (432 aa)
idh1Isocitrate dehydrogenase (NADP(+)); Belongs to the monomeric-type IDH family; KEGG: vch:VC1141 isocitrate dehydrogenase. (741 aa)
ANS85916.1Cytochrome c-type protein NapC; Belongs to the TorC/TorY family. (394 aa)
palPeptidoglycan-associated lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (171 aa)
ANS85886.1Uncharacterized protein; To H. influenzae HI_1369. (824 aa)
Your Current Organism:
Vibrio scophthalmi
NCBI taxonomy Id: 45658
Other names: CAIM 75, CECT 4638, CIP 105211, LMG 19158, LMG:19158, V. scophthalmi, strain A089
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