STRINGSTRING
ANS83875.1 ANS83875.1 ANS83941.1 ANS83941.1 ANS84039.1 ANS84039.1 envZ envZ ANS84223.1 ANS84223.1 cpdB cpdB lptC lptC ANS84355.1 ANS84355.1 ANS84506.1 ANS84506.1 ANS84572.1 ANS84572.1 dacC dacC lnt lnt ANS84752.1 ANS84752.1 aphA aphA ANS84891.1 ANS84891.1 ANS84961.1 ANS84961.1 mltG mltG ANS85079.1 ANS85079.1 ANS85084.1 ANS85084.1 ANS85142.1 ANS85142.1 ANS85148.1 ANS85148.1 ANS85232.1 ANS85232.1 ANS85345.1 ANS85345.1 ctpA ctpA ANS85467.1 ANS85467.1 ANS85647.1 ANS85647.1 ANS85737.1 ANS85737.1 ANS85791.1 ANS85791.1 ANS85812.1 ANS85812.1 ANS85881.1 ANS85881.1 pqqL pqqL cpoB cpoB ANS86000.1 ANS86000.1 ANS86080.1 ANS86080.1 ANS86084.1 ANS86084.1 ANS86149.1 ANS86149.1 ANS86215.1 ANS86215.1 mepA mepA ANS86350.1 ANS86350.1 ANS86448.1 ANS86448.1 pqqL-2 pqqL-2 ANS86597.1 ANS86597.1 ANS86657.1 ANS86657.1 cpxA-2 cpxA-2 ANS87061.1 ANS87061.1 ANS87106.1 ANS87106.1 ANS87190.1 ANS87190.1 ANS87413.1 ANS87413.1 ANS87418.1 ANS87418.1 ANS87426.1 ANS87426.1 tesA tesA ANS87565.1 ANS87565.1 ANS87610.1 ANS87610.1 ANS87648.1 ANS87648.1 ANS87686.1 ANS87686.1 ANS87820.1 ANS87820.1 ANS87874.1 ANS87874.1 ANS87954.1 ANS87954.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANS83875.1Hypothetical protein. (109 aa)
ANS83941.1Putative peptide-binding periplasmic protein; Probably part of an ABC transporter complex that could be involved in peptide import; Belongs to the bacterial solute-binding protein 5 family. (517 aa)
ANS84039.1Hypothetical protein. (557 aa)
envZHistidine kinase; Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals. Contains 1 HAMP domain; Contains 1 histidine kinase domain; KEGG: vch:VC2713 two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ. (434 aa)
ANS84223.1Putative lipoprotein GfcD. (735 aa)
cpdB2',3'-cyclic-nucleotide 2'-phosphodiesterase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate; Belongs to the 5'-nucleotidase family; KEGG: vvu:VV1_0728 2',3'-cyclic-nucleotide 2'-phosphodiesterase. (683 aa)
lptCHypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (187 aa)
ANS84355.1Putative phospholipid-binding protein MlaC; Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane; Belongs to the MlaC/ttg2D family. (212 aa)
ANS84506.1Possible binding-protein with either a transport or enzymatic activity. Belongs to the bacterial solute-binding protein 5 family. (560 aa)
ANS84572.1Soluble lytic murein transglycosylase; Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity); Belongs to the transglycosylase Slt family; KEGG: gps:C427_5355 soluble lytic murein transglycosylase; Glycosidases, i. e. enzymes hydrolyzing O- and S-glycosyl compounds. (651 aa)
dacCSerine-type D-Ala-D-Ala carboxypeptidase; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Belongs to the peptidase S11 family; KEGG: vcy:IX92_11620 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6). (392 aa)
lntApolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (504 aa)
ANS84752.1Hypothetical protein. (378 aa)
aphAAcid phosphatase; Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds (By similarity); Belongs to the class B bacterial acid phosphatase family; KEGG: eic:NT01EI_3833 acid phosphatase (class B). (235 aa)
ANS84891.1Membrane-bound lytic murein transglycosylase. (324 aa)
ANS84961.1Uncharacterized protein; Contains 2 HhH domains. (104 aa)
mltGUPF0755 protein YceG; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (338 aa)
ANS85079.1Periplasmic murein peptide-binding protein; Essential for the uptake of the murein peptide L-alanyl- gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha- linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system. Belongs to the bacterial solute-binding protein 5 family. (542 aa)
ANS85084.1Spermidine/putrescine-binding periplasmic protein; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family. (342 aa)
ANS85142.1Choloylglycine hydrolase; Belongs to the peptidase C59 family; KEGG: shl:Shal_0591 choloylglycine hydrolase. (362 aa)
ANS85148.1Nopaline-binding periplasmic protein; Component of the nopaline active transport system probably consisting of four subunits: Q, M, P and T. This system is also capable of transporting octopine provided that catabolic functions are induced with nopaline. Belongs to the bacterial solute-binding protein 3 family. (255 aa)
ANS85232.1Putative alkyl/aryl-sulfatase YjcS; Belongs to the metallo-beta-lactamase superfamily; KEGG: vfi:VF_A0035 uncharacterized sulfatase; Sulfuric ester hydrolases. (651 aa)
ANS85345.1Putative ABC transporter arginine-binding protein; Part of the ABC transporter complex ArtPIQMJ involved in arginine transport; Belongs to the bacterial solute-binding protein 3 family. (243 aa)
ctpAC-terminal processing peptidase; Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses. Belongs to the peptidase S41A family; Contains 1 PDZ (DHR) domain; KEGG: vch:VC1496 carboxyl-terminal processing protease. (664 aa)
ANS85467.1Spermidine/putrescine-binding periplasmic protein; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family. (345 aa)
ANS85647.1Uncharacterized protein; To H. influenzae HI_1666. (165 aa)
ANS85737.1KEGG: vsp:VS_II0926 choloylglycine hydrolase. (345 aa)
ANS85791.1Hypothetical protein. (147 aa)
ANS85812.1Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis. Belongs to the bacterial solute-binding protein 5 family. (547 aa)
ANS85881.1Protein TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy- dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to sp [...] (222 aa)
pqqLPutative zinc protease PqqL; Belongs to the peptidase M16 family; KEGG: pmr:PMI3704 zinc protease; Metalloendopeptidases. (943 aa)
cpoBUncharacterized protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (257 aa)
ANS86000.1Thiol:disulfide interchange protein DsbE; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily; Contains 1 thioredoxin domain. (183 aa)
ANS86080.1Thiol:disulfide interchange protein; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily; Contains 1 thioredoxin domain. (174 aa)
ANS86084.1Cytochrome c-type protein NrfB; Plays a role in nitrite reduction. (195 aa)
ANS86149.1Hypothetical protein. (289 aa)
ANS86215.1Membrane-bound lytic murein transglycosylase; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi (By similarity). (366 aa)
mepAPenicillin-insensitive murein endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus. (291 aa)
ANS86350.1Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells; Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family. (438 aa)
ANS86448.1Hypothetical protein. (375 aa)
pqqL-2Putative zinc protease; Belongs to the peptidase M16 family; KEGG: vsp:VS_2565 zinc protease; Metalloendopeptidases. (952 aa)
ANS86597.1Thiamine-binding periplasmic protein; Part of the ABC transporter complex ThiBPQ involved in thiamine import; Belongs to the bacterial solute-binding protein 1 family. (335 aa)
ANS86657.1Activator of the cell wall hydrolases AmiA and AmiB. Required for septal murein cleavage and daughter cell separation during cell division. In vitro, exhibits weak endoproteolytic activity on beta-casein; Belongs to the peptidase M23B family. (380 aa)
cpxA-2Histidine kinase; This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synthesis, translocation, or stability of cell envelope proteins. Activates CpxR by phosphorylation (By similarity); Contains 1 HAMP domain; Contains 1 histidine kinase domain; KEGG: vvu:VV1_1253 two-component system, OmpR family, sensor histidine kinase CpxA. (460 aa)
ANS87061.1HTH-type transcriptional regulator SgrR; Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain; Contains 1 HTH marR-type DNA-binding domain. (583 aa)
ANS87106.1Multidrug resistance protein MdtN; Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family. (345 aa)
ANS87190.1Alkyl/aryl-sulfatase. Enables the use of SDS and 4- nitrocatechol as sulfur source; Belongs to the metallo-beta-lactamase superfamily; KEGG: vfi:VF_A0035 uncharacterized sulfatase; Sulfuric ester hydrolases. (673 aa)
ANS87413.1Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis. Belongs to the bacterial solute-binding protein 5 family. (504 aa)
ANS87418.1Maltose operon periplasmic protein; Not yet known. Might function in the uptake of a still unidentified substrate. To S. typhimurium MalM. (280 aa)
ANS87426.1Alpha-amylase; Since only maltooligosaccharides up to a chain length of 6 glucose units are actively transported through the cytoplasmic membrane via the membrane-bound complex of three proteins, MalF, MalG, and MalK, longer maltooligosaccharides must first be degraded by the periplasmic alpha-amylase, the MalS protein. Belongs to the glycosyl hydrolase 13 family; KEGG: vcy:IX92_23125 alpha-amylase. (686 aa)
tesAEsterase that exhibits the highest activity towards Tween detergents and p-nitrophenyl esters of short acyl chain length. Also displays a low thioesterase activity towards palmitoyl-coenzyme A, but is not active towards acetyl-coenzyme A; Belongs to the 'GDSL' lipolytic enzyme family; KEGG: lag:N175_15565 acyl-CoA thioesterase I; Thiolester hydrolases. (200 aa)
ANS87565.1Molybdate-binding periplasmic protein; Involved in the transport of molybdenum into the cell. Binds molybdate with high specificity and affinity. Belongs to the bacterial solute-binding protein ModA family. (262 aa)
ANS87610.1HTH-type transcriptional regulator SgrR; Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain; Contains 1 HTH marR-type DNA-binding domain. (574 aa)
ANS87648.1Hypothetical protein. (231 aa)
ANS87686.1Uncharacterized protein; To H. influenzae HbpA. (605 aa)
ANS87820.1Periplasmic alpha-galactoside-binding protein; Probably involved in an alpha-galactosides intake transport system. Belongs to the bacterial solute-binding protein 5 family. (686 aa)
ANS87874.1Iron(3+)-hydroxamate-binding protein; Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin. Belongs to the bacterial solute-binding protein 8 family; Contains 1 Fe/B12 periplasmic-binding domain. (318 aa)
ANS87954.1Serine-type D-Ala-D-Ala carboxypeptidase; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Belongs to the peptidase S11 family; KEGG: amt:Amet_2528 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6). (388 aa)
Your Current Organism:
Vibrio scophthalmi
NCBI taxonomy Id: 45658
Other names: CAIM 75, CECT 4638, CIP 105211, LMG 19158, LMG:19158, V. scophthalmi, strain A089
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