STRINGSTRING
ANS87455.1 ANS87455.1 malX malX putA putA ANS86736.1 ANS86736.1 hflC hflC ANS86575.1 ANS86575.1 ANS86450.1 ANS86450.1 ANS86350.1 ANS86350.1 lpoA lpoA ANS86280.1 ANS86280.1 ANS86271.1 ANS86271.1 ftsA ftsA ftsE ftsE hemG hemG ANS84019.1 ANS84019.1 dnaA dnaA ANS84248.1 ANS84248.1 cafA cafA umpA umpA bamD bamD bamA bamA ANS84716.1 ANS84716.1 ANS84888.1 ANS84888.1 ppiD ppiD lapB lapB rne rne dmsA dmsA ANS85098.1 ANS85098.1 ANS85120.1 ANS85120.1 ANS86208.1 ANS86208.1 gamP gamP syd syd ANS86086.1 ANS86086.1 ANS86079.1 ANS86079.1 ANS86016.1 ANS86016.1 ANS86010.1 ANS86010.1 ccmA ccmA ccmE ccmE ANS85999.1 ANS85999.1 ANS85998.1 ANS85998.1 torA torA ANS85881.1 ANS85881.1 ANS85810.1 ANS85810.1 hflD hflD ANS87864.1 ANS87864.1 dld dld
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANS87455.1Putative cellulose biosynthesis protein BcsQ; Essential for cellulose biosynthesis. May play a role in subcellular localization of an active cellulose biosynthesis apparatus at the bacterial cell pole; Belongs to the BcsQ family. (258 aa)
malXThe phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity); Contains 1 PTS EIIA type-1 domain; Contains 1 PTS EIIB type-1 domain; Contains 1 PTS EIIC type-1 domain; KEGG: cdg:CDBI1_14950 PTS system, maltose and glucose-specific IIB component. (527 aa)
putAProline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1042 aa)
ANS86736.1Hypothetical protein. (230 aa)
hflCProtein HflC; HflC and HflK could regulate a protease. (327 aa)
ANS86575.1Uncharacterized protein. (253 aa)
ANS86450.1Hypothetical protein. (200 aa)
ANS86350.1Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells; Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family. (438 aa)
lpoAPenicillin-binding protein activator LpoA; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. (626 aa)
ANS86280.1Long-chain-fatty-acid--CoA ligase; Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process. May mediate fatty acid retrieval from the lumen of endosomes into the cytoplasm; Belongs to the ATP-dependent AMP-binding enzyme family; KEGG: asd:AS9A_3933 long-chain acyl-CoA synthetase. (561 aa)
ANS86271.1Hypothetical protein. (411 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (420 aa)
ftsEEnergy-coupling factor transporter ATP-binding protein EcfA1; Part of the ABC transporter FtsEX involved in cellular division. (224 aa)
hemGCatalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX using menaquinone as electron acceptor; Contains 1 flavodoxin-like domain; KEGG: vvu:VV1_0978 menaquinone-dependent protoporphyrinogen oxidase. (175 aa)
ANS84019.1Inhibits the initiation of sporulation, Spo0J antagonizes this inhibition. Soj ultimately inhibits the activation (phosphorylation) of Spo0A. It is not required for chromosome partitioning (By similarity); Belongs to the ParA family. (257 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (468 aa)
ANS84248.1Glutathione amide-dependent peroxidase; Catalyzes the oxidation of glutathione amide (GASH) to produce glutathione amide disulfide (GASSAG). May play a role in GASH metabolism under anaerobic conditions as a sulfide carrier necessary for cytoplasmic sulfide oxidation; Contains 1 glutaredoxin domain; Contains 1 thioredoxin domain; KEGG: vfi:VF_2300 peroxiredoxin; Peroxidases. (242 aa)
cafARibonuclease; Involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filaments bundles or merely regulate the formation of this structure (By similarity); Belongs to the RNase E/G family. RNase G subfamily; Contains 1 S1 motif domain; KEGG: eco:b3247 ribonuclease G; Endoribonucleases producing 5'-phosphomonoesters. (489 aa)
umpAProlipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (274 aa)
bamDOuter membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (241 aa)
bamAOuter membrane protein assembly factor BamA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (800 aa)
ANS84716.1The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity); Contains 1 PTS EIIA type-1 domain; KEGG: eco:b2417 PTS system, glucose-specific IIA component. (169 aa)
ANS84888.1Septum site-determining protein MinD; ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity); Belongs to the ParA family. MinD subfamily. (270 aa)
ppiDPeptidylprolyl isomerase; PPIases accelerate the folding of proteins; Contains 1 PpiC domain; KEGG: vch:VC1918 peptidyl-prolyl cis-trans isomerase D. (619 aa)
lapBLipopolysaccharide assembly protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (389 aa)
rneRibonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1044 aa)
dmsADimethylsulfoxide reductase; Catalyzes the reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS). DMSO reductase serves as the terminal reductase under anaerobic conditions, with DMSO being the terminal electron acceptor. Terminal reductase during anaerobic growth on various sulfoxides and N-oxide compounds. Allows E. coli to grow anaerobically on DMSO as respiratory oxidant; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family; Contains 1 4Fe-4S Mo/W bis-MGD-type domain; KEGG: yel:LC20_03833 anaerobic dimethyl sulfoxide reductase subunit A. (814 aa)
ANS85098.1Anaerobic dimethyl sulfoxide reductase chain; Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Contains 3 4Fe-4S ferredoxin-type domains. (205 aa)
ANS85120.1Penicillin-binding protein activator LpoB; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b); Belongs to the LpoB family. (196 aa)
ANS86208.1UPF0070 protein YfgM; Belongs to the UPF0070 family. (204 aa)
gamPThe phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity); Contains 1 PTS EIIA type-1 domain; Contains 1 PTS EIIB type-1 domain; Contains 1 PTS EIIC type-1 domain; KEGG: vni:VIBNI_A0269 PTS system, D-glucosamine-specific IIA component. (503 aa)
sydProtein Syd; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. (181 aa)
ANS86086.1Formate-dependent nitrite reductase complex subunit; Required for formate-dependent nitrite reduction. Not required for the biosynthesis of any of the c-type cytochromes nor for the secretion of the periplasmic cytochromes. Contains 2 TPR repeats. (179 aa)
ANS86079.1Formate-dependent nitrite reductase complex bifunctional subunit NrfFG; Possible subunit of a heme lyase. (157 aa)
ANS86016.1Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; In the N-terminal sectio; belongs to the MIP18 family; In the C-terminal sectio; belongs to the Mrp/NBP35 ATP-binding proteins family. (295 aa)
ANS86010.1Inhibits the initiation of sporulation, Spo0J antagonizes this inhibition. Soj ultimately inhibits the activation (phosphorylation) of Spo0A. It is not required for chromosome partitioning (By similarity); Belongs to the ParA family. (258 aa)
ccmACytochrome c bioproteinis ATP-binding export protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (206 aa)
ccmECytochrome c-type bioproteinis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (161 aa)
ANS85999.1Cytochrome c-type bioproteinis protein CcmH; Possible subunit of a heme lyase. (159 aa)
ANS85998.1Putative cytochrome c-type bioproteinis protein CcmH; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase (By similarity); Belongs to the CcmH/CycL/Ccl2/NrfF family; Contains 2 TPR repeats. (406 aa)
torATrimethylamine-N-oxide reductase (cytochrome c); Reduces trimethylamine-N-oxide (TMAO) into trimethylamin; an anaerobic reaction coupled to energy-yielding reactions; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family; KEGG: vch:VC1692 trimethylamine-N-oxide reductase (cytochrome c). (820 aa)
ANS85881.1Protein TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy- dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to sp [...] (222 aa)
ANS85810.1The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspA negatively regulates expression of the pspABCDE promoter and of pspG through negative regulation of the psp-specific transcriptional activator PspF. Is also required for membrane integrity, efficient translocation and maintenance of the proton motive force (By similarity); Belongs to the PspA/IM30 family. (222 aa)
hflDHigh frequency lysogenization protein HflD like protein; Belongs to the HflD family. (205 aa)
ANS87864.1Hypothetical protein. (407 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (567 aa)
Your Current Organism:
Vibrio scophthalmi
NCBI taxonomy Id: 45658
Other names: CAIM 75, CECT 4638, CIP 105211, LMG 19158, LMG:19158, V. scophthalmi, strain A089
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