(15 nodes) Mixed, incl. AP-2 adaptor complex, and Beta-adaptin appendage, C-terminal subdomain network (Zea mays)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	A0A1D6HGI4	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family. (522 aa)
	Cl584_1b	AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. (1068 aa)
	A0A1D6K3D9	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (853 aa)
	A0A1D6KAJ0	Uncharacterized protein. (2157 aa)
	A0A1D6MY50	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (156 aa)
	A0A1D6NI64	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (854 aa)
	A0A1D6PL97	AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. (1065 aa)
	AY111142	Adaptin ear-binding coat-associated protein 2. (284 aa)
	Pco091249(431)	Adaptin ear-binding coat-associated protein 1 NECAP-1. (289 aa)
	CAS_MAIZE	Calcium sensing receptor, chloroplastic; Modulates cytoplasmic Ca(2+) concentration and is crucial for proper stomatal regulation in response to elevated levels of external Ca(2+). May function by regulating concentrations of inositol 1,4,5- trisphosphate (IP3), which in turn triggers release of Ca(2+) from internal stores. May play a role in de-etiolation. (395 aa)
	C0HEB4_MAIZE	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	C0PHP0_MAIZE	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (637 aa)
	C0PPF5_MAIZE	Calcium sensing receptor chloroplastic. (395 aa)
	K7WDG3_MAIZE	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (898 aa)
	AP-17	AP-2 complex subunit sigma; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP2S1/AP17 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositides. (132 aa)

Your Current Organism:

Zea mays

NCBI taxonomy Id: 4577
Other names: Z. mays, Zea mays L., Zea mays var. japonica, maize

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1D6HGI4	A0A1D6K3D9	A0A1D6HGI4	A0A1D6K3D9	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.926
A0A1D6HGI4	A0A1D6KAJ0	A0A1D6HGI4	A0A1D6KAJ0	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	Uncharacterized protein.	0.992
A0A1D6HGI4	A0A1D6MY50	A0A1D6HGI4	A0A1D6MY50	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.969
A0A1D6HGI4	A0A1D6NI64	A0A1D6HGI4	A0A1D6NI64	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.924
A0A1D6HGI4	A0A1D6PL97	A0A1D6HGI4	A0A1D6PL97	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome.	0.981
A0A1D6HGI4	AP-17	A0A1D6HGI4	O50016	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	AP-2 complex subunit sigma; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP2S1/AP17 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositides.	0.968
A0A1D6HGI4	AY111142	A0A1D6HGI4	B4FAZ6	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	Adaptin ear-binding coat-associated protein 2.	0.952
A0A1D6HGI4	C0HEB4_MAIZE	A0A1D6HGI4	C0HEB4	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.968
A0A1D6HGI4	C0PHP0_MAIZE	A0A1D6HGI4	C0PHP0	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.941
A0A1D6HGI4	Cl584_1b	A0A1D6HGI4	A0A1D6JKY6	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome.	0.981
A0A1D6HGI4	K7WDG3_MAIZE	A0A1D6HGI4	K7WDG3	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.926
A0A1D6HGI4	Pco091249(431)	A0A1D6HGI4	B4FRD1	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	Adaptin ear-binding coat-associated protein 1 NECAP-1.	0.952
A0A1D6K3D9	A0A1D6HGI4	A0A1D6K3D9	A0A1D6HGI4	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	0.926
A0A1D6K3D9	A0A1D6KAJ0	A0A1D6K3D9	A0A1D6KAJ0	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	Uncharacterized protein.	0.990
A0A1D6K3D9	A0A1D6MY50	A0A1D6K3D9	A0A1D6MY50	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.885
A0A1D6K3D9	A0A1D6PL97	A0A1D6K3D9	A0A1D6PL97	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome.	0.939
A0A1D6K3D9	AP-17	A0A1D6K3D9	O50016	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP-2 complex subunit sigma; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP2S1/AP17 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositides.	0.885
A0A1D6K3D9	AY111142	A0A1D6K3D9	B4FAZ6	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	Adaptin ear-binding coat-associated protein 2.	0.859
A0A1D6K3D9	C0HEB4_MAIZE	A0A1D6K3D9	C0HEB4	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.885
A0A1D6K3D9	C0PHP0_MAIZE	A0A1D6K3D9	C0PHP0	Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.828