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metAA metAA MCCL_0060 MCCL_0060 MCCL_0180 MCCL_0180 metE metE MCCL_0318 MCCL_0318 MCCL_0330 MCCL_0330 MCCL_0582 MCCL_0582 rocD rocD argH argH argG argG thrA thrA MCCL_0985 MCCL_0985 thrC thrC thrB thrB MCCL_1046 MCCL_1046 MCCL_1047 MCCL_1047 lysC lysC asd asd dapA dapA dapB dapB dapD dapD MCCL_1053 MCCL_1053 alr2 alr2 lysA lysA proC proC mtnN mtnN ald ald MCCL_1377 MCCL_1377 MCCL_1389 MCCL_1389 MCCL_1427 MCCL_1427 MCCL_1451 MCCL_1451 metK metK MCCL_1639 MCCL_1639 MCCL_1651 MCCL_1651 MCCL_1661 MCCL_1661 speH speH speE speE MCCL_1664 MCCL_1664 MCCL_1665 MCCL_1665 MCCL_1666 MCCL_1666 MCCL_1789 MCCL_1789 MCCL_1790 MCCL_1790 luxS luxS cysE cysE cysK cysK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
metAAConserved hypothetical protein; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (254 aa)
MCCL_0060O-acetylhomoserine (thiol)-lyase homolog. (425 aa)
MCCL_0180Conserved hypothetical protein; Similar to aminotransferase family protein. (387 aa)
metEMethionine synthase II. (385 aa)
MCCL_0318Arginase homolog; Belongs to the arginase family. (301 aa)
MCCL_0330Conserved hypothetical protein; Similar to homocysteine S-methyltransferase. (295 aa)
MCCL_0582Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (514 aa)
rocDOrnithine aminotransferase; Catalyzes the interconversion of ornithine to glutamate semialdehyde. (397 aa)
argHArgininosuccinate lyase. (457 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa)
thrAAspartate kinase; Belongs to the aspartokinase family. (448 aa)
MCCL_0985Homoserine dehydrogenase homolog. (404 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (358 aa)
thrBConserved hypothetical protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (300 aa)
MCCL_1046Conserved hypothetical protein; Similar to functionally unknown protein; Belongs to the CvfB family. (288 aa)
MCCL_1047ABC transporter, ATP-binding protein. (533 aa)
lysCAspartokinase II; Belongs to the aspartokinase family. (407 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (240 aa)
dapDTetrahydrodipicolinate acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (238 aa)
MCCL_1053Hippurate hydrolase homolog. (381 aa)
alr2Alanine racemase 2; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (360 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (423 aa)
proCPyrroline-5-carboxylate reductase homolog; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa)
mtnN5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase homolog; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (233 aa)
aldAlanine dehydrogenase; Belongs to the AlaDH/PNT family. (371 aa)
MCCL_1377Conserved hypothetical protein; Similar to universal stress protein UspA. (166 aa)
MCCL_1389Conserved hypothetical protein; Similar to functionally unknown protein. (155 aa)
MCCL_1427Conserved hypothetical protein; Similar to aminotransferase. (396 aa)
MCCL_1451Conserved hypothetical protein; Similar to proline dehydrogenase. (330 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (396 aa)
MCCL_1639High affinity proline permease; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (510 aa)
MCCL_1651Conserved hypothetical protein; Similar to nitric-oxide synthase. (348 aa)
MCCL_1661Conserved hypothetical protein; Similar to lysine decarboxylase. (502 aa)
speHS-adenosylmethionine decarboxylase homolog; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (141 aa)
speESpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (286 aa)
MCCL_1664Conserved hypothetical protein; Similar to agmatinase; Belongs to the arginase family. (283 aa)
MCCL_1665Conserved hypothetical protein; Similar to functionally unknown protein. (143 aa)
MCCL_1666Hypothetical protein. (343 aa)
MCCL_1789Hypothetical protein. (506 aa)
MCCL_1790Cystathionine gamma-synthase homolog. (381 aa)
luxSAutoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (161 aa)
cysESerine acetyltransferase. (234 aa)
cysKCysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa)
Your Current Organism:
Macrococcus caseolyticus
NCBI taxonomy Id: 458233
Other names: M. caseolyticus JCSC5402, Macrococcus caseolyticus JCSC5402, Macrococcus caseolyticus str. JCSC5402, Macrococcus caseolyticus strain JCSC5402
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