(104 nodes) Mixed, incl. Transmembrane receptor protein tyrosine kinase signaling pathway, and Receptor signaling pathway via STAT network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A0R3NHH1	Signal transducer and activator of transcription 5B. (792 aa)
	A0A0R3NI60	Uncharacterized protein, isoform A. (767 aa)
	A0A0R3NJU0	annotation not available (968 aa)
	A0A0R3NLE1	Uncharacterized protein, isoform B. (486 aa)
	A0A0R3NLK6	Serine/threonine-protein kinase SIK3. (1494 aa)
	A0A0R3NMK2	Uncharacterized protein, isoform F. (3903 aa)
	A0A0R3NNZ3	Uncharacterized protein, isoform A. (1711 aa)
	A0A0R3NP57	Uncharacterized protein, isoform B. (1145 aa)
	A0A0R3NQA7	Rap guanine nucleotide exchange factor 4. (1006 aa)
	A0A0R3NQB3	Uncharacterized protein. (242 aa)
	A0A0R3NQF8	Uncharacterized protein. (774 aa)
	A0A0R3NQH0	Uncharacterized protein, isoform B. (1874 aa)
	DpseGA25836	Uncharacterized protein, isoform D. (958 aa)
	A0A0R3NS54	Tyrosine-protein kinase receptor torso. (939 aa)
	A0A0R3NSV7	MAP/microtubule affinity-regulating kinase. (1192 aa)
	A0A0R3NSV9	Uncharacterized protein, isoform A. (1515 aa)
	A0A0R3NU81	Uncharacterized protein, isoform B. (248 aa)
	DpseGA10508	Uncharacterized protein, isoform B. (973 aa)
	DpseGA19056	IRS-type PTB domain-containing protein. (272 aa)
	DpseGA16131	Uncharacterized protein, isoform J. (1645 aa)
	DpseGA31069	Uncharacterized protein. (426 aa)
	DpseGA16481	Uncharacterized protein, isoform D. (614 aa)
	DpseGA20666	Uncharacterized protein, isoform B. (983 aa)
	DpseGA28105	FERM domain-containing protein. (122 aa)
	DpseGA31934	Uncharacterized protein. (76 aa)
	DpseGA19279	Uncharacterized protein, isoform B. (438 aa)
	DpseGA32610	Uncharacterized protein. (840 aa)
	DpseGA22812	Uncharacterized protein, isoform B. (1637 aa)
	DpseGA31462	Uncharacterized protein. (1072 aa)
	DpseGA21923	Uncharacterized protein, isoform B. (255 aa)
	DpseGA28338	Tyrosine-protein kinase. (552 aa)
	A0A158SUH3	Uncharacterized protein. (392 aa)
	DpseGA28770	Uncharacterized protein. (1618 aa)
	DpseGA22759	Uncharacterized protein, isoform A; Belongs to the 14-3-3 family. (250 aa)
	DpseGA23049	Uncharacterized protein, isoform A. (179 aa)
	DpseGA27851	Uncharacterized protein, isoform F. (996 aa)
	DpseGA28420	Uncharacterized protein. (203 aa)
	DpseGA27172	Uncharacterized protein. (247 aa)
	DpseGA22327	Uncharacterized protein. (382 aa)
	DpseGA22282	Uncharacterized protein. (194 aa)
	DpseGA28339	Protein kinase domain-containing protein. (234 aa)
	DpseGA22407	Uncharacterized protein. (6349 aa)
	B5DW47	Ras-related protein Ral-A. (200 aa)
	B5DX59	Uncharacterized protein. (2795 aa)
	B5DYR5	Insulin-like growth factor 1 receptor. (2293 aa)
	B5E030	Connector enhancer of kinase suppressor of Ras 2. (1598 aa)
	B5E0W7	Ras-related protein Rap-2C. (182 aa)
	I5AN24	Uncharacterized protein, isoform B. (1581 aa)
	I5APB1	Uncharacterized protein, isoform C. (1114 aa)
	I5APZ2	Uncharacterized protein. (214 aa)
	Q28XM9	Uncharacterized protein, isoform A. (1439 aa)
	Q28YW0	Uncharacterized protein, isoform A. (703 aa)
	Q28ZK7	Uncharacterized protein. (195 aa)
	Q28ZT1	Growth factor receptor-binding protein 2. (211 aa)
	otk	Tyrosine-protein kinase-like otk; Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons (By similarity). (1037 aa)
	Q290N6	Uncharacterized protein. (428 aa)
	Q291B4	Sprouty-related, EVH1 domain-containing protein. (541 aa)
	Dpse_fak	Focal adhesion kinase 1. (1530 aa)
	Q293K0	Uncharacterized protein, isoform A. (563 aa)
	Q293S6	MAP/microtubule affinity-regulating kinase. (735 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	Q296F4	Kinase suppressor of Ras 2. (1012 aa)
	Q296J3	Uncharacterized protein. (849 aa)
	Q296W0	Uncharacterized protein, isoform A. (262 aa)
	Q296X7	Uncharacterized protein, isoform A. (899 aa)
	Q299I2	DIRAS family, GTP-binding Ras-like 2. (233 aa)
	Q29AY5	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta. (1112 aa)
	Q29BH0	Ras-related C3 botulinum toxin substrate 1. (195 aa)
	Q29C19	Uncharacterized protein. (199 aa)
	DpseGA13993	Uncharacterized protein. (297 aa)
	DpseGA11132	Uncharacterized protein. (192 aa)
	DpseGA21595	Uncharacterized protein, isoform A. (570 aa)
	DpseGA11414	Uncharacterized protein, isoform A. (805 aa)
	DpseGA19811	Uncharacterized protein. (1200 aa)
	DpseGA17637	Uncharacterized protein. (423 aa)
	dos	Dos, isoform A. (884 aa)
	DpseGA19890	Uncharacterized protein, isoform B. (2865 aa)
	DpseGA19283	Uncharacterized protein. (539 aa)
	DpseGA16990	Ras-GAP domain-containing protein. (2123 aa)
	DpseGA15227	Uncharacterized protein. (656 aa)
	DpseGA15484	Uncharacterized protein. (201 aa)
	DpseGA11287	Uncharacterized protein, isoform B. (1126 aa)
	DpseGA14036	Uncharacterized protein. (1178 aa)
	DpseGA14059	Uncharacterized protein, isoform A. (1082 aa)
	DpseGA12840	Uncharacterized protein. (1318 aa)
	DpseGA12839	Uncharacterized protein. (846 aa)
	DpseGA14783	Uncharacterized protein. (2527 aa)
	DpseGA13960	Uncharacterized protein, isoform A. (524 aa)
	DpseGA15481	Uncharacterized protein, isoform A. (839 aa)
	DpseGA18086	Protein kinase domain-containing protein. (1481 aa)
	DpseGA17230	Uncharacterized protein, isoform A. (961 aa)
	DpseGA21827	Uncharacterized protein, isoform A. (1614 aa)
	DpseGA14336	Uncharacterized protein, isoform A. (123 aa)
	DpseGA13535	Uncharacterized protein. (759 aa)
	DpseGA21705	Uncharacterized protein, isoform A. (181 aa)
	DpseGA20207	Uncharacterized protein. (2215 aa)
	DpseGA20789	Tyrosine-protein kinase. (798 aa)
	DpseGA15435	Uncharacterized protein. (515 aa)
	DpseGA12256	IRS-type PTB domain-containing protein. (472 aa)
	DpseGA16907	Uncharacterized protein. (238 aa)
	DpseGA20050	Uncharacterized protein, isoform A. (889 aa)
	DpseGA21377	Uncharacterized protein. (987 aa)
	DpseGA15150	Uncharacterized protein. (184 aa)
	EndoA	Endophilin-A; Required presynaptically at the neuromuscular junction. Implicated in synaptic vesicle endocytosis. Belongs to the endophilin family. (369 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NHH1	A0A0R3NNZ3	A0A0R3NHH1	A0A0R3NNZ3	Signal transducer and activator of transcription 5B.	Uncharacterized protein, isoform A.	0.683
A0A0R3NHH1	A0A0R3NQB3	A0A0R3NHH1	A0A0R3NQB3	Signal transducer and activator of transcription 5B.	Uncharacterized protein.	0.402
A0A0R3NHH1	A0A0R3NQF8	A0A0R3NHH1	A0A0R3NQF8	Signal transducer and activator of transcription 5B.	Uncharacterized protein.	0.402
A0A0R3NHH1	A0A0R3NQH0	A0A0R3NHH1	A0A0R3NQH0	Signal transducer and activator of transcription 5B.	Uncharacterized protein, isoform B.	0.402
A0A0R3NHH1	A0A0R3NS54	A0A0R3NHH1	A0A0R3NS54	Signal transducer and activator of transcription 5B.	Tyrosine-protein kinase receptor torso.	0.438
A0A0R3NHH1	A0A0R3NSV9	A0A0R3NHH1	A0A0R3NSV9	Signal transducer and activator of transcription 5B.	Uncharacterized protein, isoform A.	0.421
A0A0R3NHH1	B5DYR5	A0A0R3NHH1	B5DYR5	Signal transducer and activator of transcription 5B.	Insulin-like growth factor 1 receptor.	0.414
A0A0R3NHH1	DpseGA10508	A0A0R3NHH1	A0A0R3NV00	Signal transducer and activator of transcription 5B.	Uncharacterized protein, isoform B.	0.414
A0A0R3NHH1	DpseGA12839	A0A0R3NHH1	Q29HY7	Signal transducer and activator of transcription 5B.	Uncharacterized protein.	0.675
A0A0R3NHH1	DpseGA12840	A0A0R3NHH1	Q29HY6	Signal transducer and activator of transcription 5B.	Uncharacterized protein.	0.839
A0A0R3NHH1	DpseGA13535	A0A0R3NHH1	Q29LD7	Signal transducer and activator of transcription 5B.	Uncharacterized protein.	0.804
A0A0R3NHH1	DpseGA14036	A0A0R3NHH1	Q29H22	Signal transducer and activator of transcription 5B.	Uncharacterized protein.	0.982
A0A0R3NHH1	DpseGA14783	A0A0R3NHH1	Q29HZ3	Signal transducer and activator of transcription 5B.	Uncharacterized protein.	0.590
A0A0R3NHH1	DpseGA15435	A0A0R3NHH1	Q29NX3	Signal transducer and activator of transcription 5B.	Uncharacterized protein.	0.550
A0A0R3NHH1	DpseGA15481	A0A0R3NHH1	Q29IQ6	Signal transducer and activator of transcription 5B.	Uncharacterized protein, isoform A.	0.446
A0A0R3NHH1	DpseGA19279	A0A0R3NHH1	A0A0R3P1N6	Signal transducer and activator of transcription 5B.	Uncharacterized protein, isoform B.	0.588
A0A0R3NHH1	DpseGA19283	A0A0R3NHH1	Q29G27	Signal transducer and activator of transcription 5B.	Uncharacterized protein.	0.722
A0A0R3NHH1	DpseGA21595	A0A0R3NHH1	Q29DV4	Signal transducer and activator of transcription 5B.	Uncharacterized protein, isoform A.	0.842
A0A0R3NHH1	DpseGA21705	A0A0R3NHH1	Q29LX6	Signal transducer and activator of transcription 5B.	Uncharacterized protein, isoform A.	0.683
A0A0R3NHH1	DpseGA21923	A0A0R3NHH1	A0A0R3P471	Signal transducer and activator of transcription 5B.	Uncharacterized protein, isoform B.	0.683