(61 nodes) Mixed, incl. Energy dependent regulation of mTOR by LKB1-AMPK, and Cellular response to amino acid starvation network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A0R3NFW7	Uncharacterized protein, isoform B. (2852 aa)
	A0A0R3NJQ3	Uncharacterized protein. (131 aa)
	A0A0R3NNN3	annotation not available (1373 aa)
	DpseGA31101	Uncharacterized protein. (134 aa)
	DpseGA31774	Uncharacterized protein. (1601 aa)
	DpseGA32390	Raptor_N domain-containing protein. (1683 aa)
	DpseGA18654	Uncharacterized protein, isoform B; Belongs to the PI3/PI4-kinase family. (2501 aa)
	DpseGA32385	Uncharacterized protein, isoform A. (60 aa)
	DpseGA11387	Uncharacterized protein, isoform E. (1562 aa)
	DpseGA32796	Uncharacterized protein. (710 aa)
	DpseGA28399	Uncharacterized protein, isoform D. (915 aa)
	DpseGA28030	Uncharacterized protein. (275 aa)
	DpseGA28091	Uncharacterized protein. (264 aa)
	DpseGA22314	Uncharacterized protein, isoform A. (548 aa)
	DpseGA22494	Protein kinase domain-containing protein. (1437 aa)
	B5DVQ5	Calcium/calmodulin-dependent protein kinase kinase 2. (708 aa)
	DpseGA21624	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (334 aa)
	Q28YR8	Ragulator complex protein LAMTOR2. (125 aa)
	Q28YX1	Uncharacterized protein. (395 aa)
	Q28ZB3	5'-AMP-activated protein kinase, regulatory beta subunit. (337 aa)
	Q28ZC8	Solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 11. (526 aa)
	Q28ZG4	Uncharacterized protein. (498 aa)
	Q28ZI5	Uncharacterized protein. (172 aa)
	Q28ZX7	Ras-related GTP-binding protein C/D. (377 aa)
	Q290Y1	Uncharacterized protein. (354 aa)
	Q291E3	Uncharacterized protein. (569 aa)
	Sin1	Stress-activated map kinase-interacting protein 1; Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. (578 aa)
	Q294V1	RAC serine/threonine-protein kinase. (530 aa)
	Q295G1	Uncharacterized protein, isoform D. (595 aa)
	Q296E3	Ras-related GTP-binding protein A/B. (311 aa)
	Q296G6	Ras homolog enriched in brain. (182 aa)
	Q297P6	Serine/threonine-protein kinase 11. (553 aa)
	Q298J4	TBC1 domain family member 7. (292 aa)
	Q298J9	Uncharacterized protein, isoform A. (1107 aa)
	Q29BT6	WD repeat-containing protein 24. (813 aa)
	DpseGA17944	Uncharacterized protein. (339 aa)
	DpseGA17671	UDENN FNIP1/2-type domain-containing protein. (1495 aa)
	DpseGA21949	Uncharacterized protein, isoform B. (621 aa)
	DpseGA10383	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
	DpseGA21319	Uncharacterized protein. (636 aa)
	DpseGA17458	Uncharacterized protein, isoform A. (236 aa)
	GA13399	Ragulator complex protein LAMTOR4 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity). (121 aa)
	DpseGA12812	Uncharacterized protein. (180 aa)
	DpseGA21545	Uncharacterized protein. (393 aa)
	DpseGA20757	Uncharacterized protein. (1964 aa)
	GA15597	Protein LST8 homolog. (315 aa)
	DpseGA21635	Mitochondrial inner membrane protease subunit. (160 aa)
	DpseGA13265	Uncharacterized protein. (103 aa)
	DpseGA10994	Protein kinase domain-containing protein. (287 aa)
	DpseGA15892	Non-specific serine/threonine protein kinase. (587 aa)
	DpseGA14570	Non-specific serine/threonine protein kinase. (960 aa)
	DpseGA21876	Uncharacterized protein. (274 aa)
	DpseGA12046	Uncharacterized protein, isoform A. (321 aa)
	DpseGA17249	Uncharacterized protein. (275 aa)
	DpseGA18666	Uncharacterized protein. (128 aa)
	DpseGA18315	Uncharacterized protein, isoform B. (517 aa)
	DpseGA18371	Uncharacterized protein. (986 aa)
	DpseGA20081	Uncharacterized protein, isoform A. (871 aa)
	DpseGA18860	Protein kinase domain-containing protein. (490 aa)
	DpseGA21211	UDENN FLCN/SMCR8-type domain-containing protein. (482 aa)
	DpseGA19997	Rap-GAP domain-containing protein. (1864 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NFW7	DpseGA10994	A0A0R3NFW7	Q29IZ5	Uncharacterized protein, isoform B.	Protein kinase domain-containing protein.	0.443
A0A0R3NFW7	DpseGA15892	A0A0R3NFW7	Q29IZ7	Uncharacterized protein, isoform B.	Non-specific serine/threonine protein kinase.	0.433
A0A0R3NFW7	DpseGA18315	A0A0R3NFW7	Q29LI2	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform B.	0.462
A0A0R3NFW7	DpseGA21624	A0A0R3NFW7	N6WBR0	Uncharacterized protein, isoform B.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.422
A0A0R3NFW7	Q28YX1	A0A0R3NFW7	Q28YX1	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.514
A0A0R3NFW7	Q297P6	A0A0R3NFW7	Q297P6	Uncharacterized protein, isoform B.	Serine/threonine-protein kinase 11.	0.644
A0A0R3NJQ3	DpseGA18654	A0A0R3NJQ3	A0A0R3P0E1	Uncharacterized protein.	Uncharacterized protein, isoform B; Belongs to the PI3/PI4-kinase family.	0.719
A0A0R3NJQ3	DpseGA19997	A0A0R3NJQ3	Q2M0Y0	Uncharacterized protein.	Rap-GAP domain-containing protein.	0.555
A0A0R3NJQ3	DpseGA20757	A0A0R3NJQ3	Q29GP0	Uncharacterized protein.	Uncharacterized protein.	0.727
A0A0R3NJQ3	DpseGA28399	A0A0R3NJQ3	A0A0R3P909	Uncharacterized protein.	Uncharacterized protein, isoform D.	0.780
A0A0R3NJQ3	DpseGA32390	A0A0R3NJQ3	A0A0R3P030	Uncharacterized protein.	Raptor_N domain-containing protein.	0.737
A0A0R3NJQ3	GA15597	A0A0R3NJQ3	Q29HG9	Uncharacterized protein.	Protein LST8 homolog.	0.577
A0A0R3NJQ3	Q28ZX7	A0A0R3NJQ3	Q28ZX7	Uncharacterized protein.	Ras-related GTP-binding protein C/D.	0.477
A0A0R3NJQ3	Q294V1	A0A0R3NJQ3	Q294V1	Uncharacterized protein.	RAC serine/threonine-protein kinase.	0.549
A0A0R3NJQ3	Q296E3	A0A0R3NJQ3	Q296E3	Uncharacterized protein.	Ras-related GTP-binding protein A/B.	0.501
A0A0R3NJQ3	Sin1	A0A0R3NJQ3	Q291K8	Uncharacterized protein.	Stress-activated map kinase-interacting protein 1; Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.	0.682
A0A0R3NNN3	B5DVQ5	A0A0R3NNN3	B5DVQ5	annotation not available	Calcium/calmodulin-dependent protein kinase kinase 2.	0.728
A0A0R3NNN3	DpseGA10994	A0A0R3NNN3	Q29IZ5	annotation not available	Protein kinase domain-containing protein.	0.708
A0A0R3NNN3	DpseGA12812	A0A0R3NNN3	Q29F07	annotation not available	Uncharacterized protein.	0.483
A0A0R3NNN3	DpseGA15892	A0A0R3NNN3	Q29IZ7	annotation not available	Non-specific serine/threonine protein kinase.	0.960