(11 nodes) Behavioral response to cocaine, and Replication fork arrest network (Drosophila pseudoobscura)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	A0A0R3NGG8	Uncharacterized protein. (775 aa)
	A0A0R3NM33	Uncharacterized protein. (675 aa)
	DpseGA21284	Uncharacterized protein, isoform B. (434 aa)
	per	Period circadian protein; Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promot [...] (1271 aa)
	Q28WY5	Uncharacterized protein. (210 aa)
	cry	Cryptochrome-1; Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Light induces the degradation of cry, likely due to conformational change in the photoreceptor leading to targeting to the proteasome. Under circadian regulation, expression is influenced by the clock pacemaker genes period, timeless, Clock and cycle. Binding to tim irreversibly commits tim to proteasomal degra [...] (540 aa)
	Q29CD4	Uncharacterized protein, isoform D. (439 aa)
	DpseGA20318	Uncharacterized protein. (1037 aa)
	DpseGA19443	Uncharacterized protein. (733 aa)
	DpseGA15376	Uncharacterized protein, isoform A. (533 aa)
	DpseGA16835	TIMELESS domain-containing protein. (1238 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NGG8	A0A0R3NM33	A0A0R3NGG8	A0A0R3NM33	Uncharacterized protein.	Uncharacterized protein.	0.932
A0A0R3NGG8	DpseGA15376	A0A0R3NGG8	Q29LV7	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.793
A0A0R3NGG8	DpseGA20318	A0A0R3NGG8	Q29EN9	Uncharacterized protein.	Uncharacterized protein.	0.486
A0A0R3NGG8	DpseGA21284	A0A0R3NGG8	A0A0R3P8C0	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.489
A0A0R3NGG8	cry	A0A0R3NGG8	Q293P8	Uncharacterized protein.	Cryptochrome-1; Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Light induces the degradation of cry, likely due to conformational change in the photoreceptor leading to targeting to the proteasome. Under circadian regulation, expression is influenced by the clock pacemaker genes period, timeless, Clock and cycle. Binding to tim irreversibly commits tim to proteasomal degra [...]	0.817
A0A0R3NGG8	per	A0A0R3NGG8	P12348	Uncharacterized protein.	Period circadian protein; Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promot [...]	0.816
A0A0R3NM33	A0A0R3NGG8	A0A0R3NM33	A0A0R3NGG8	Uncharacterized protein.	Uncharacterized protein.	0.932
A0A0R3NM33	DpseGA15376	A0A0R3NM33	Q29LV7	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.793
A0A0R3NM33	DpseGA20318	A0A0R3NM33	Q29EN9	Uncharacterized protein.	Uncharacterized protein.	0.486
A0A0R3NM33	DpseGA21284	A0A0R3NM33	A0A0R3P8C0	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.489
A0A0R3NM33	cry	A0A0R3NM33	Q293P8	Uncharacterized protein.	Cryptochrome-1; Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Light induces the degradation of cry, likely due to conformational change in the photoreceptor leading to targeting to the proteasome. Under circadian regulation, expression is influenced by the clock pacemaker genes period, timeless, Clock and cycle. Binding to tim irreversibly commits tim to proteasomal degra [...]	0.817
A0A0R3NM33	per	A0A0R3NM33	P12348	Uncharacterized protein.	Period circadian protein; Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promot [...]	0.816
DpseGA15376	A0A0R3NGG8	Q29LV7	A0A0R3NGG8	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.793
DpseGA15376	A0A0R3NM33	Q29LV7	A0A0R3NM33	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.793
DpseGA15376	DpseGA16835	Q29LV7	Q29MC5	Uncharacterized protein, isoform A.	TIMELESS domain-containing protein.	0.946
DpseGA15376	DpseGA19443	Q29LV7	Q29JD8	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.655
DpseGA15376	DpseGA20318	Q29LV7	Q29EN9	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.781
DpseGA15376	DpseGA21284	Q29LV7	A0A0R3P8C0	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform B.	0.900
DpseGA15376	Q28WY5	Q29LV7	Q28WY5	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.736
DpseGA15376	Q29CD4	Q29LV7	Q29CD4	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform D.	0.736