(74 nodes) Gene silencing by RNA, and P granule organization network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A0R3NIX8	Eukaryotic translation initiation factor 2C. (679 aa)
	A0A0R3NM84	Uncharacterized protein, isoform A. (1909 aa)
	A0A0R3NN90	Uncharacterized protein. (257 aa)
	A0A0R3NP31	Uncharacterized protein, isoform B. (1290 aa)
	DpseGA28948	Uncharacterized protein, isoform B. (242 aa)
	DpseGA28114	Uncharacterized protein, isoform B. (913 aa)
	DpseGA30757	Uncharacterized protein. (90 aa)
	DpseGA30527	Maelstrom domain-containing protein. (139 aa)
	DpseGA31311	Uncharacterized protein, isoform B. (911 aa)
	DpseGA32116	Piwi domain-containing protein. (145 aa)
	DpseGA22965	ArgoN domain-containing protein. (219 aa)
	DpseGA32509	Uncharacterized protein, isoform A. (180 aa)
	DpseGA16600	Uncharacterized protein, isoform C. (1414 aa)
	DpseGA30562	PAZ domain-containing protein. (629 aa)
	DpseGA31112	Maelstrom domain-containing protein. (423 aa)
	DpseGA32770	Piwi domain-containing protein. (121 aa)
	DpseGA25304	Uncharacterized protein. (1169 aa)
	DpseGA25965	DRBM domain-containing protein. (398 aa)
	DpseGA26008	Uncharacterized protein. (845 aa)
	DpseGA25698	Uncharacterized protein. (488 aa)
	DpseGA22807	Uncharacterized protein. (177 aa)
	DpseGA23527	Uncharacterized protein. (695 aa)
	DpseGA23464	Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (247 aa)
	DpseGA23629	Uncharacterized protein. (946 aa)
	mael1	Protein maelstrom 1; Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in [...] (371 aa)
	mael2	Protein maelstrom 2; Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in [...] (370 aa)
	DpseGA25552	Uncharacterized protein. (481 aa)
	DpseGA22560	Uncharacterized protein, isoform A. (330 aa)
	DpseGA27639	Uncharacterized protein. (568 aa)
	DpseGA27879	Uncharacterized protein. (1016 aa)
	DpseGA23171	Uncharacterized protein. (668 aa)
	DpseGA22530	Uncharacterized protein. (211 aa)
	B5DX04	Uncharacterized protein. (438 aa)
	B5DXJ1	Tudor domain-containing protein 5. (471 aa)
	B5DY62	Eukaryotic translation initiation factor 2C. (972 aa)
	B5DYR9	Eukaryotic translation initiation factor 2C. (980 aa)
	B5DYS1	Uncharacterized protein. (339 aa)
	B5E144	Uncharacterized protein. (296 aa)
	I5ANY8	Uncharacterized protein. (922 aa)
	Q28X52	Tudor domain-containing protein 5. (594 aa)
	Q28XE1	Uncharacterized protein. (285 aa)
	Q28XI6	Uncharacterized protein. (248 aa)
	Q28XU3	KH domain-containing, RNA-binding, signal transduction-associated protein 3. (393 aa)
	Q28YB7	Uncharacterized protein. (1292 aa)
	Q28ZJ1	Uncharacterized protein. (1362 aa)
	Q28ZU1	Eukaryotic translation initiation factor 2C. (985 aa)
	Q290Q6	Double-stranded RNA-binding protein Staufen. (1008 aa)
	Q290S3	Uncharacterized protein, isoform A. (818 aa)
	Q291A3	Uncharacterized protein, isoform A. (1726 aa)
	Q291N7	Uncharacterized protein. (2994 aa)
	Q291W4	Tudor domain-containing protein 1/4/6/7. (2521 aa)
	Q292K6	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1. (463 aa)
	Q293E5	Small RNA 2'-O-methyltransferase. (383 aa)
	Q293G0	FK506-binding protein 6. (441 aa)
	Q293U3	Uncharacterized protein. (669 aa)
	spn-E	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...] (1433 aa)
	Q297R3	Microprocessor complex subunit DGCR8. (667 aa)
	Q298R6	Uncharacterized protein. (662 aa)
	Q298W1	Tudor domain-containing protein 1/4/6/7. (918 aa)
	Q299N3	Tudor domain-containing protein 1/4/6/7. (1935 aa)
	Q29AU1	Uncharacterized protein. (2280 aa)
	Q29AU3	Uncharacterized protein. (703 aa)
	Q29BD9	Uncharacterized protein. (299 aa)
	DpseGA19370	Uncharacterized protein; Belongs to the argonaute family. (848 aa)
	DpseGA10795	Uncharacterized protein, isoform A. (1624 aa)
	DpseGA20026	Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (928 aa)
	DpseGA14273	Uncharacterized protein. (1292 aa)
	DpseGA14198	A to I editase domain-containing protein. (403 aa)
	DpseGA11531	Ig-like domain-containing protein. (886 aa)
	DpseGA11550	PLDc_2 domain-containing protein. (240 aa)
	DpseGA20129	Uncharacterized protein, isoform A. (314 aa)
	DpseGA19382	Uncharacterized protein, isoform A; Belongs to the argonaute family. (851 aa)
	DpseGA19915	Uncharacterized protein, isoform A. (477 aa)
	DpseGA16644	Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (388 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NIX8	DpseGA16600	A0A0R3NIX8	A0A0R3P174	Eukaryotic translation initiation factor 2C.	Uncharacterized protein, isoform C.	0.689
A0A0R3NIX8	DpseGA19915	A0A0R3NIX8	Q29P93	Eukaryotic translation initiation factor 2C.	Uncharacterized protein, isoform A.	0.499
A0A0R3NIX8	DpseGA22530	A0A0R3NIX8	B5DV75	Eukaryotic translation initiation factor 2C.	Uncharacterized protein.	0.499
A0A0R3NIX8	DpseGA25698	A0A0R3NIX8	B5DIM8	Eukaryotic translation initiation factor 2C.	Uncharacterized protein.	0.498
A0A0R3NIX8	DpseGA32116	A0A0R3NIX8	A0A0R3NXH5	Eukaryotic translation initiation factor 2C.	Piwi domain-containing protein.	0.506
A0A0R3NIX8	Q28XI6	A0A0R3NIX8	Q28XI6	Eukaryotic translation initiation factor 2C.	Uncharacterized protein.	0.454
A0A0R3NIX8	Q28YB7	A0A0R3NIX8	Q28YB7	Eukaryotic translation initiation factor 2C.	Uncharacterized protein.	0.475
A0A0R3NIX8	Q291A3	A0A0R3NIX8	Q291A3	Eukaryotic translation initiation factor 2C.	Uncharacterized protein, isoform A.	0.615
A0A0R3NIX8	Q29AU1	A0A0R3NIX8	Q29AU1	Eukaryotic translation initiation factor 2C.	Uncharacterized protein.	0.615
A0A0R3NIX8	Q29BD9	A0A0R3NIX8	Q29BD9	Eukaryotic translation initiation factor 2C.	Uncharacterized protein.	0.462
A0A0R3NM84	Q28XE1	A0A0R3NM84	Q28XE1	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.452
A0A0R3NM84	Q290S3	A0A0R3NM84	Q290S3	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.450
A0A0R3NN90	spn-E	A0A0R3NN90	Q296Q5	Uncharacterized protein.	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...]	0.400
A0A0R3NP31	Q291W4	A0A0R3NP31	Q291W4	Uncharacterized protein, isoform B.	Tudor domain-containing protein 1/4/6/7.	0.448
A0A0R3NP31	Q292K6	A0A0R3NP31	Q292K6	Uncharacterized protein, isoform B.	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1.	0.515
B5DX04	spn-E	B5DX04	Q296Q5	Uncharacterized protein.	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...]	0.473
B5DXJ1	DpseGA11550	B5DXJ1	Q29LZ0	Tudor domain-containing protein 5.	PLDc_2 domain-containing protein.	0.534
B5DXJ1	DpseGA14273	B5DXJ1	Q29K20	Tudor domain-containing protein 5.	Uncharacterized protein.	0.546
B5DXJ1	DpseGA19370	B5DXJ1	Q29CN1	Tudor domain-containing protein 5.	Uncharacterized protein; Belongs to the argonaute family.	0.485
B5DXJ1	DpseGA19382	B5DXJ1	Q29P29	Tudor domain-containing protein 5.	Uncharacterized protein, isoform A; Belongs to the argonaute family.	0.485