(5 nodes) This domain is named PAZ after the proteins Piwi Argonaut and Zwille. This domain is found in two families of proteins that are involved in post-transcriptional gene silencing. These are the Piwi family and the Dicer family, that includes the Carpel ..., and SNase-like, OB-fold superfamily network (Drosophila pseudoobscura)

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Your Input:
	DpseGA25552	Uncharacterized protein. (481 aa)
	Q291W4	Tudor domain-containing protein 1/4/6/7. (2521 aa)
	spn-E	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...] (1433 aa)
	DpseGA19370	Uncharacterized protein; Belongs to the argonaute family. (848 aa)
	DpseGA19382	Uncharacterized protein, isoform A; Belongs to the argonaute family. (851 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DpseGA19370	DpseGA19382	Q29CN1	Q29P29	Uncharacterized protein; Belongs to the argonaute family.	Uncharacterized protein, isoform A; Belongs to the argonaute family.	0.908
DpseGA19370	DpseGA25552	Q29CN1	B5DT44	Uncharacterized protein; Belongs to the argonaute family.	Uncharacterized protein.	0.927
DpseGA19370	Q291W4	Q29CN1	Q291W4	Uncharacterized protein; Belongs to the argonaute family.	Tudor domain-containing protein 1/4/6/7.	0.887
DpseGA19370	spn-E	Q29CN1	Q296Q5	Uncharacterized protein; Belongs to the argonaute family.	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...]	0.788
DpseGA19382	DpseGA19370	Q29P29	Q29CN1	Uncharacterized protein, isoform A; Belongs to the argonaute family.	Uncharacterized protein; Belongs to the argonaute family.	0.908
DpseGA19382	DpseGA25552	Q29P29	B5DT44	Uncharacterized protein, isoform A; Belongs to the argonaute family.	Uncharacterized protein.	0.960
DpseGA19382	Q291W4	Q29P29	Q291W4	Uncharacterized protein, isoform A; Belongs to the argonaute family.	Tudor domain-containing protein 1/4/6/7.	0.957
DpseGA19382	spn-E	Q29P29	Q296Q5	Uncharacterized protein, isoform A; Belongs to the argonaute family.	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...]	0.771
DpseGA25552	DpseGA19370	B5DT44	Q29CN1	Uncharacterized protein.	Uncharacterized protein; Belongs to the argonaute family.	0.927
DpseGA25552	DpseGA19382	B5DT44	Q29P29	Uncharacterized protein.	Uncharacterized protein, isoform A; Belongs to the argonaute family.	0.960
DpseGA25552	Q291W4	B5DT44	Q291W4	Uncharacterized protein.	Tudor domain-containing protein 1/4/6/7.	0.836
DpseGA25552	spn-E	B5DT44	Q296Q5	Uncharacterized protein.	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...]	0.685
Q291W4	DpseGA19370	Q291W4	Q29CN1	Tudor domain-containing protein 1/4/6/7.	Uncharacterized protein; Belongs to the argonaute family.	0.887
Q291W4	DpseGA19382	Q291W4	Q29P29	Tudor domain-containing protein 1/4/6/7.	Uncharacterized protein, isoform A; Belongs to the argonaute family.	0.957
Q291W4	DpseGA25552	Q291W4	B5DT44	Tudor domain-containing protein 1/4/6/7.	Uncharacterized protein.	0.836
Q291W4	spn-E	Q291W4	Q296Q5	Tudor domain-containing protein 1/4/6/7.	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...]	0.735
spn-E	DpseGA19370	Q296Q5	Q29CN1	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...]	Uncharacterized protein; Belongs to the argonaute family.	0.788
spn-E	DpseGA19382	Q296Q5	Q29P29	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...]	Uncharacterized protein, isoform A; Belongs to the argonaute family.	0.771
spn-E	DpseGA25552	Q296Q5	B5DT44	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...]	Uncharacterized protein.	0.685
spn-E	Q291W4	Q296Q5	Q291W4	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...]	Tudor domain-containing protein 1/4/6/7.	0.735