(37 nodes) Positive regulation of epithelial cell migration network (Drosophila pseudoobscura)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	DpseGA20137	Uncharacterized protein. (1263 aa)
	DpseGA20050	Uncharacterized protein, isoform A. (889 aa)
	DpseGA18669	WD_REPEATS_REGION domain-containing protein. (427 aa)
	DpseGA17762	Uncharacterized protein, isoform A. (949 aa)
	DpseGA16373	Uncharacterized protein, isoform A. (745 aa)
	DpseGA10324	Uncharacterized protein. (448 aa)
	DpseGA17619	Uncharacterized protein, isoform D. (5833 aa)
	DpseGA20104	Uncharacterized protein, isoform A; Belongs to the PDGF/VEGF growth factor family. (323 aa)
	DpseGA17546	Uncharacterized protein, isoform A. (174 aa)
	DpseGA11481	Uncharacterized protein. (1960 aa)
	DpseGA12050	Uncharacterized protein, isoform B. (2127 aa)
	DpseGA10287	Uncharacterized protein. (421 aa)
	DpseGA15506	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (748 aa)
	A0A0R3NP70	DnaJ homolog subfamily C member 13. (2409 aa)
	A0A0R3NSV7	MAP/microtubule affinity-regulating kinase. (1192 aa)
	DpseGA20908	Receptor protein-tyrosine kinase. (1649 aa)
	DpseGA19056	IRS-type PTB domain-containing protein. (272 aa)
	DpseGA26435	Uncharacterized protein, isoform C. (1782 aa)
	DpseGA23680	Uncharacterized protein, isoform C. (439 aa)
	DpseGA25451	Uncharacterized protein, isoform A. (316 aa)
	DpseGA22607	Uncharacterized protein, isoform A. (1248 aa)
	small-wing	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1250 aa)
	B5DX68	F-box and WD-40 domain protein 1/11. (590 aa)
	B5DYR5	Insulin-like growth factor 1 receptor. (2293 aa)
	B5E1G4	Uncharacterized protein, isoform A. (1517 aa)
	I5ANT7	Dedicator of cytokinesis protein 1. (2003 aa)
	Q28WU5	CCAAT/enhancer binding protein (C/EBP), invertebrate. (455 aa)
	Q28XM9	Uncharacterized protein, isoform A. (1439 aa)
	Q28Z58	Origin recognition complex subunit 3. (713 aa)
	vir	Protein virilizer; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Required for proper inclusion of regulated exons in Ubx trans [...] (1849 aa)
	Q294V1	RAC serine/threonine-protein kinase. (530 aa)
	Dpse_ttk	Tramtrack, isoform F. (829 aa)
	Q299A1	Dual specificity phosphatase 10. (489 aa)
	Q29AY5	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta. (1112 aa)
	DpseGA10349	Uncharacterized protein. (637 aa)
	DpseGA20413	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1212 aa)
	DpseGA15321	Uncharacterized protein. (192 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B5DX68	Q294V1	B5DX68	Q294V1	F-box and WD-40 domain protein 1/11.	RAC serine/threonine-protein kinase.	0.576
B5DYR5	DpseGA19056	B5DYR5	A0A0R3NWK0	Insulin-like growth factor 1 receptor.	IRS-type PTB domain-containing protein.	0.998
B5DYR5	DpseGA20050	B5DYR5	Q2LYL3	Insulin-like growth factor 1 receptor.	Uncharacterized protein, isoform A.	0.944
B5DYR5	Q28XM9	B5DYR5	Q28XM9	Insulin-like growth factor 1 receptor.	Uncharacterized protein, isoform A.	0.941
B5DYR5	Q29AY5	B5DYR5	Q29AY5	Insulin-like growth factor 1 receptor.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.	0.958
B5E1G4	DpseGA17546	B5E1G4	Q29GG1	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.447
B5E1G4	Q28XM9	B5E1G4	Q28XM9	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.582
B5E1G4	Q294V1	B5E1G4	Q294V1	Uncharacterized protein, isoform A.	RAC serine/threonine-protein kinase.	0.593
DpseGA10287	DpseGA25451	Q29JX9	B5DHP1	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.521
DpseGA10349	Q28XM9	Q29E55	Q28XM9	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.997
DpseGA10349	Q29AY5	Q29E55	Q29AY5	Uncharacterized protein.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.	0.557
DpseGA15321	DpseGA15506	Q29EV6	Q29KX2	Uncharacterized protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.420
DpseGA15321	DpseGA17546	Q29EV6	Q29GG1	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.454
DpseGA15321	DpseGA20050	Q29EV6	Q2LYL3	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.478
DpseGA15321	I5ANT7	Q29EV6	I5ANT7	Uncharacterized protein.	Dedicator of cytokinesis protein 1.	0.824
DpseGA15321	Q28XM9	Q29EV6	Q28XM9	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.529
DpseGA15321	Q294V1	Q29EV6	Q294V1	Uncharacterized protein.	RAC serine/threonine-protein kinase.	0.501
DpseGA15321	Q29AY5	Q29EV6	Q29AY5	Uncharacterized protein.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.	0.525
DpseGA15321	small-wing	Q29EV6	B5DNH4	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.581
DpseGA15506	DpseGA15321	Q29KX2	Q29EV6	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	Uncharacterized protein.	0.420