(119 nodes) Endosomal transport network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DpseGA11331	Uncharacterized protein, isoform E. (4384 aa)
	DpseGA21512	Uncharacterized protein, isoform A. (1417 aa)
	DpseGA10514	GLUE N-terminal domain-containing protein. (399 aa)
	DpseGA17938	Uncharacterized protein. (322 aa)
	Q29CF3	Uncharacterized protein. (320 aa)
	Q29CF0	Vacuolar protein sorting-associated protein 16. (834 aa)
	Q29BS2	Uncharacterized protein. (167 aa)
	Q29AQ9	ESCRT-II complex subunit VPS22. (253 aa)
	Q299V4	EH domain-containing protein 1. (540 aa)
	Q297T1	VPS33B-interacting protein in polarity and apical restriction. (454 aa)
	Q296Z4	Charged multivesicular body protein 2A. (256 aa)
	Q296Z3	Exocyst complex component 8. (682 aa)
	Q296V6	Ras-related protein Rab-11A. (214 aa)
	Q296V4	Exocyst complex component 6. (763 aa)
	Q296S2	E3 ubiquitin-protein ligase RNF13. (551 aa)
	Q296A5	RAB6A-GEF complex partner protein 2. (434 aa)
	Q295Z5	Ubiquitin-conjugating enzyme E2 A. (151 aa)
	Q295T0	GRIP and coiled-coil domain-containing protein 2. (1144 aa)
	Q295E5	Charged multivesicular body protein 3. (223 aa)
	Q294Z3	Uncharacterized protein, isoform A. (1978 aa)
	Q294G5	Vacuolar protein sorting-associated protein 33B. (646 aa)
	Q292N5	ESCRT-II complex subunit VPS25. (174 aa)
	Q292C2	WAS protein family homolog 1. (491 aa)
	Q291X2	Vacuolar protein sorting-associated protein 51. (738 aa)
	Q291D3	Biogenesis of lysosome-related organelles complex 1 subunit 1. (146 aa)
	Q290X2	ESCRT-I complex subunit VPS28. (211 aa)
	Q290H7	Charged multivesicular body protein 6. (212 aa)
	Q28ZP1	WASH complex subunit FAM21. (1318 aa)
	Q28ZN5	Exocyst complex component 3. (738 aa)
	Q28ZB4	Uncharacterized protein, isoform A. (952 aa)
	Q28Z17	Epidermal growth factor receptor substrate 15. (1255 aa)
	Q28Y57	Lysosomal-associated transmembrane protein. (429 aa)
	Q28XN2	MAD, mothers against decapentaplegic interacting protein. (1352 aa)
	Q28XG2	Uncharacterized protein. (959 aa)
	I7KU16	Uncharacterized protein, isoform B. (1239 aa)
	I5APE5	Uncharacterized protein, isoform A. (1060 aa)
	DpseGA18414	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (182 aa)
	DpseGA18251	Uncharacterized protein. (690 aa)
	DpseGA18149	Uncharacterized protein, isoform A. (642 aa)
	DpseGA17388	Vps53_N domain-containing protein. (897 aa)
	DpseGA15402	Protein kinase domain-containing protein. (719 aa)
	DpseGA19427	Uncharacterized protein, isoform A. (937 aa)
	DpseGA11282	Uncharacterized protein. (538 aa)
	DpseGA17598	Uncharacterized protein, isoform A. (218 aa)
	DpseGA14601	Uncharacterized protein. (534 aa)
	DpseGA17967	FERM domain-containing protein. (1515 aa)
	DpseGA21362	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (897 aa)
	DpseGA15459	PX domain-containing protein. (456 aa)
	DpseGA19714	Uncharacterized protein. (208 aa)
	DpseGA12524	Uncharacterized protein. (1068 aa)
	DpseGA20303	Uncharacterized protein. (665 aa)
	DpseGA17672	Uncharacterized protein. (935 aa)
	DpseGA19660	Uncharacterized protein, isoform A. (683 aa)
	DpseGA21553	Myotubularin phosphatase domain-containing protein. (619 aa)
	DpseGA11605	PH domain-containing protein. (302 aa)
	DpseGA18929	Uncharacterized protein. (444 aa)
	DpseGA17963	Uncharacterized protein. (204 aa)
	DpseGA20728	Uncharacterized protein. (320 aa)
	DpseGA12787	Uncharacterized protein. (164 aa)
	DpseGA20143	VPS9 domain-containing protein. (1506 aa)
	DpseGA19908	Uncharacterized protein. (290 aa)
	DpseGA19474	Uncharacterized protein. (228 aa)
	EndoA	Endophilin-A; Required presynaptically at the neuromuscular junction. Implicated in synaptic vesicle endocytosis. Belongs to the endophilin family. (369 aa)
	I5ANL3	Uncharacterized protein, isoform A. (952 aa)
	B5E0I2	Vacuolar protein sorting-associated protein 35. (822 aa)
	B5DZD7	Uncharacterized protein. (330 aa)
	B5DZD0	Uncharacterized protein. (142 aa)
	B5DZ84	Uncharacterized protein, isoform A. (205 aa)
	B5DWH8	Uncharacterized protein, isoform A. (942 aa)
	DpseGA23298	Uncharacterized protein. (122 aa)
	DpseGA29225	Uncharacterized protein. (207 aa)
	DpseGA28117	GED domain-containing protein. (167 aa)
	DpseGA25617	RING-type domain-containing protein. (850 aa)
	DpseGA23654	Uncharacterized protein. (1883 aa)
	DpseGA23499	Uncharacterized protein, isoform A. (207 aa)
	DpseGA28953	Uncharacterized protein. (614 aa)
	DpseGA25900	Vesicle transport protein; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family. (205 aa)
	DpseGA19394	Uncharacterized protein, isoform B. (198 aa)
	DpseGA23801	Uncharacterized protein, isoform C. (554 aa)
	DpseGA30983	Uncharacterized protein. (125 aa)
	DpseGA12783	Uncharacterized protein, isoform B. (232 aa)
	DpseGA18654	Uncharacterized protein, isoform B; Belongs to the PI3/PI4-kinase family. (2501 aa)
	DpseGA25944	Uncharacterized protein. (186 aa)
	DpseGA10688	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1056 aa)
	DpseGA20953	Uncharacterized protein, isoform B. (454 aa)
	DpseGA26020	Uncharacterized protein, isoform F. (612 aa)
	DpseGA31371	Vps16_C domain-containing protein. (303 aa)
	DpseGA27655	Uncharacterized protein, isoform B. (1147 aa)
	DpseGA10691	Uncharacterized protein, isoform F. (1159 aa)
	A0A0R3NUA3	Charged multivesicular body protein 4. (232 aa)
	A0A0R3NSB9	Vacuolar protein sorting-associated protein 51. (201 aa)
	A0A0R3NRL3	annotation not available (814 aa)
	A0A0R3NMU4	Uncharacterized protein, isoform A. (3416 aa)
	A0A0R3NL21	Uncharacterized protein, isoform B. (2456 aa)
	A0A0R3NKI2	Uncharacterized protein, isoform A. (324 aa)
	A0A0R3NJN1	Trafficking protein particle complex subunit 10. (1147 aa)
	A0A0R3NJ45	Uncharacterized protein, isoform A. (2176 aa)
	DpseGA15506	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (748 aa)
	DpseGA16224	Uncharacterized protein. (473 aa)
	DpseGA18036	Uncharacterized protein, isoform A. (243 aa)
	DpseGA22174	Uncharacterized protein, isoform A. (259 aa)
	DpseGA13260	Uncharacterized protein. (522 aa)
	DpseGA15921	Pep3_Vps18 domain-containing protein. (1003 aa)
	DpseGA12841	FERM domain-containing protein. (636 aa)
	DpseGA19899	Uncharacterized protein, isoform A; Belongs to the AAA ATPase family. (441 aa)
	DpseGA20171	Uncharacterized protein, isoform A. (365 aa)
	DpseGA12994	Uncharacterized protein, isoform A. (1110 aa)
	DpseGA21885	Uncharacterized protein. (200 aa)
	DpseGA12656	Uncharacterized protein, isoform A. (1109 aa)
	DpseGA11493	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (618 aa)
	DpseGA10107	RING-type domain-containing protein. (1239 aa)
	DpseGA18306	Uncharacterized protein. (212 aa)
	DpseGA20174	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (179 aa)
	DpseGA12812	Uncharacterized protein. (180 aa)
	DpseGA13401	Uncharacterized protein. (482 aa)
	DpseGA13431	Uncharacterized protein. (152 aa)
	DpseGA19839	Sorting nexin; Belongs to the sorting nexin family. (561 aa)
	DpseGA17139	t-SNARE coiled-coil homology domain-containing protein. (230 aa)
	DpseGA10073	Uncharacterized protein, isoform A. (420 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NJ45	DpseGA10688	A0A0R3NJ45	A0A0R3NZG9	Uncharacterized protein, isoform A.	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family.	0.421
A0A0R3NJ45	DpseGA14601	A0A0R3NJ45	Q29MS8	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.418
A0A0R3NJN1	Q296V6	A0A0R3NJN1	Q296V6	Trafficking protein particle complex subunit 10.	Ras-related protein Rab-11A.	0.750
A0A0R3NL21	B5DZ84	A0A0R3NL21	B5DZ84	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.911
A0A0R3NL21	B5E0I2	A0A0R3NL21	B5E0I2	Uncharacterized protein, isoform B.	Vacuolar protein sorting-associated protein 35.	0.745
A0A0R3NL21	DpseGA11331	A0A0R3NL21	Q29DQ8	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform E.	0.545
A0A0R3NL21	DpseGA12812	A0A0R3NL21	Q29F07	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.928
A0A0R3NL21	DpseGA12994	A0A0R3NL21	Q29H53	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.544
A0A0R3NL21	DpseGA15402	A0A0R3NL21	Q29LW2	Uncharacterized protein, isoform B.	Protein kinase domain-containing protein.	0.968
A0A0R3NL21	DpseGA15506	A0A0R3NL21	Q29KX2	Uncharacterized protein, isoform B.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.436
A0A0R3NL21	DpseGA17598	A0A0R3NL21	Q29MK6	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.650
A0A0R3NL21	DpseGA18036	A0A0R3NL21	Q29KB8	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.831
A0A0R3NL21	DpseGA18654	A0A0R3NL21	A0A0R3P0E1	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform B; Belongs to the PI3/PI4-kinase family.	0.653
A0A0R3NL21	DpseGA19660	A0A0R3NL21	Q29PI9	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.557
A0A0R3NL21	DpseGA20143	A0A0R3NL21	Q2M0A1	Uncharacterized protein, isoform B.	VPS9 domain-containing protein.	0.806
A0A0R3NL21	DpseGA20174	A0A0R3NL21	Q29F85	Uncharacterized protein, isoform B.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.857
A0A0R3NL21	DpseGA22174	A0A0R3NL21	Q29K49	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.431
A0A0R3NL21	DpseGA23499	A0A0R3NL21	B5DPR3	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.474
A0A0R3NL21	DpseGA23654	A0A0R3NL21	B5DQS2	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.855
A0A0R3NL21	DpseGA25944	A0A0R3NL21	A0A0R3NZT7	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.650