(40 nodes) Regulation of macroautophagy network (Drosophila pseudoobscura)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	DpseGA18676	Uncharacterized protein. (405 aa)
	DpseGA10370	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (485 aa)
	DpseGA21524	Lipid_DES domain-containing protein; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (321 aa)
	DpseGA15892	Non-specific serine/threonine protein kinase. (587 aa)
	DpseGA15481	Uncharacterized protein, isoform A. (839 aa)
	DpseGA11442	Uncharacterized protein. (218 aa)
	DpseGA21545	Uncharacterized protein. (393 aa)
	DpseGA21319	Uncharacterized protein. (636 aa)
	Q29CG3	Uncharacterized protein. (432 aa)
	Q29CB7	Serine/threonine-protein kinase LATS1/2. (1143 aa)
	Q29BT6	WD repeat-containing protein 24. (813 aa)
	Q29BD1	Serine/threonine-protein kinase ULK3. (520 aa)
	Q29A49	Short coiled-coil protein. (135 aa)
	Q296G6	Ras homolog enriched in brain. (182 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	Q294Z3	Uncharacterized protein, isoform A. (1978 aa)
	Q293C6	Uncharacterized protein. (1152 aa)
	Q28ZN4	Ubiquitin-like modifier-activating enzyme ATG7. (681 aa)
	Q28ZJ4	Myotubularin-related protein 6/7/8. (762 aa)
	Q28ZE5	Uncharacterized protein. (323 aa)
	Q28ZG4	Uncharacterized protein. (498 aa)
	Q28XB1	Uncharacterized protein, isoform B. (336 aa)
	Q28WX1	Bcl-2-related ovarian killer protein. (302 aa)
	I7KU16	Uncharacterized protein, isoform B. (1239 aa)
	I5APE5	Uncharacterized protein, isoform A. (1060 aa)
	DpseGA20062	Uncharacterized protein. (218 aa)
	B5DYE6	Uncharacterized protein, isoform C. (3722 aa)
	B5DYB6	FK506-binding nuclear protein. (341 aa)
	DpseGA27856	Uncharacterized protein, isoform D. (877 aa)
	DpseGA28474	Uncharacterized protein. (884 aa)
	DpseGA22589	Uncharacterized protein. (224 aa)
	DpseGA18154	Uncharacterized protein, isoform B. (484 aa)
	DpseGA18654	Uncharacterized protein, isoform B; Belongs to the PI3/PI4-kinase family. (2501 aa)
	DpseGA32545	Uncharacterized protein. (1360 aa)
	A0A0R3NX75	Uncharacterized protein, isoform A. (322 aa)
	DpseGA32035	Protein kinase domain-containing protein. (157 aa)
	Dpse_Bruce	Baculoviral IAP repeat-containing protein 6 (apollon). (5087 aa)
	A0A0R3NKT4	Uncharacterized protein, isoform E. (646 aa)
	Usp36	Ubiquitin carboxyl-terminal hydrolase 36; Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins; Belongs to the peptidase C19 family. (1059 aa)
	DpseGA19997	Rap-GAP domain-containing protein. (1864 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NX75	Q28WX1	A0A0R3NX75	Q28WX1	Uncharacterized protein, isoform A.	Bcl-2-related ovarian killer protein.	0.937
B5DYB6	DpseGA18654	B5DYB6	A0A0R3P0E1	FK506-binding nuclear protein.	Uncharacterized protein, isoform B; Belongs to the PI3/PI4-kinase family.	0.438
B5DYE6	DpseGA10370	B5DYE6	Q2LYR0	Uncharacterized protein, isoform C.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.582
DpseGA10370	B5DYE6	Q2LYR0	B5DYE6	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein, isoform C.	0.582
DpseGA10370	DpseGA28474	Q2LYR0	B5DM87	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein.	0.577
DpseGA10370	DpseGA32545	Q2LYR0	A0A0R3NXA7	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein.	0.423
DpseGA10370	Dpse_Bruce	Q2LYR0	A0A0R3NKY4	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Baculoviral IAP repeat-containing protein 6 (apollon).	0.423
DpseGA10370	I7KU16	Q2LYR0	I7KU16	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein, isoform B.	0.562
DpseGA10370	Q28ZN4	Q2LYR0	Q28ZN4	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Ubiquitin-like modifier-activating enzyme ATG7.	0.726
DpseGA10370	Q29CG3	Q2LYR0	Q29CG3	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein.	0.526
DpseGA15481	DpseGA15892	Q29IQ6	Q29IZ7	Uncharacterized protein, isoform A.	Non-specific serine/threonine protein kinase.	0.421
DpseGA15481	DpseGA19997	Q29IQ6	Q2M0Y0	Uncharacterized protein, isoform A.	Rap-GAP domain-containing protein.	0.452
DpseGA15481	DpseGA32035	Q29IQ6	A0A0R3NW60	Uncharacterized protein, isoform A.	Protein kinase domain-containing protein.	0.700
DpseGA15481	DpseGA32545	Q29IQ6	A0A0R3NXA7	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.520
DpseGA15481	Dpse_Bruce	Q29IQ6	A0A0R3NKY4	Uncharacterized protein, isoform A.	Baculoviral IAP repeat-containing protein 6 (apollon).	0.520
DpseGA15481	Q296G6	Q29IQ6	Q296G6	Uncharacterized protein, isoform A.	Ras homolog enriched in brain.	0.558
DpseGA15481	Ras85D	Q29IQ6	Q295X7	Uncharacterized protein, isoform A.	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.	0.991
DpseGA15892	DpseGA15481	Q29IZ7	Q29IQ6	Non-specific serine/threonine protein kinase.	Uncharacterized protein, isoform A.	0.421
DpseGA15892	DpseGA18654	Q29IZ7	A0A0R3P0E1	Non-specific serine/threonine protein kinase.	Uncharacterized protein, isoform B; Belongs to the PI3/PI4-kinase family.	0.981
DpseGA15892	DpseGA19997	Q29IZ7	Q2M0Y0	Non-specific serine/threonine protein kinase.	Rap-GAP domain-containing protein.	0.977