(68 nodes) Negative regulation of translation network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DpseGA19054	Uncharacterized protein, isoform B. (395 aa)
	bru-3	Bruno-3, isoform AP. (461 aa)
	DpseGA23828	Uncharacterized protein, isoform G. (893 aa)
	DpseGA23356	Uncharacterized protein, isoform B. (1058 aa)
	DpseGA11027	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (804 aa)
	DpseGA14160	Uncharacterized protein. (875 aa)
	B5DWJ1	Uncharacterized protein. (1502 aa)
	B5DVU1	CCR4-NOT transcription complex subunit 9. (296 aa)
	DpseGA26118	Bin3-type SAM domain-containing protein. (1531 aa)
	DpseGA28708	Uncharacterized protein. (155 aa)
	DpseGA22412	Uncharacterized protein. (1059 aa)
	DpseGA22653	Uncharacterized protein, isoform A. (377 aa)
	DpseGA25725	Uncharacterized protein, isoform B. (818 aa)
	DpseGA25731	Uncharacterized protein, isoform B. (402 aa)
	DpseGA20948	Bin3-type SAM domain-containing protein. (1522 aa)
	I5ANY9	CCR4-NOT transcription complex subunit 6. (551 aa)
	I5AP32	Uncharacterized protein, isoform C. (319 aa)
	I5APJ0	Uncharacterized protein, isoform G. (1533 aa)
	N6W6M1	CCR4-NOT transcription complex subunit 1. (2561 aa)
	Q28X08	U6 snRNA-associated Sm-like protein LSm1. (137 aa)
	Q28X67	Exosome complex component RRP42. (296 aa)
	Q28Y86	PAB-dependent poly(A)-specific ribonuclease subunit 2. (1237 aa)
	Q28YH9	Tripartite motif-containing protein 71. (845 aa)
	Q28ZE6	Exosome complex component RRP4. (298 aa)
	Q28ZU1	Eukaryotic translation initiation factor 2C. (985 aa)
	Q290A1	Uncharacterized protein. (228 aa)
	Q292R0	MRNA-decapping enzyme 1B. (343 aa)
	Q293S2	Uncharacterized protein. (436 aa)
	Q295N4	Uncharacterized protein, isoform A. (422 aa)
	DpseGA10795	Uncharacterized protein, isoform A. (1624 aa)
	DpseGA16600	Uncharacterized protein, isoform C. (1414 aa)
	DpseGA18232	Uncharacterized protein, isoform B. (718 aa)
	DpseGA11040	Uncharacterized protein, isoform D. (1635 aa)
	DpseGA15657	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (539 aa)
	DpseGA16847	Uncharacterized protein. (254 aa)
	DpseGA18770	SAM domain-containing protein. (1037 aa)
	DpseGA20942	Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. (77 aa)
	Q297F4	YTH domain-containing family protein. (641 aa)
	Q297H9	DNA topoisomerase 2-associated protein PAT1. (979 aa)
	Q297L1	Uncharacterized protein. (373 aa)
	Q297M7	Large subunit ribosomal protein L13Ae. (205 aa)
	Q29A65	Cytoplasmic polyadenylation element-binding protein. (902 aa)
	Q29BS1	CCR4-NOT transcription complex subunit 10. (641 aa)
	A0A0R3NTB8	annotation not available (1489 aa)
	DpseGA21588	Uncharacterized protein. (245 aa)
	DpseGA12633	PHD-type domain-containing protein. (232 aa)
	I5AN96	Uncharacterized protein. (392 aa)
	A0A0R3NH54	Polypyrimidine tract-binding protein 1. (818 aa)
	A0A0R3NHQ7	CCR4-NOT transcription complex subunit 2. (574 aa)
	A0A0R3NLP3	Fragile X mental retardation protein. (702 aa)
	A0A0R3NQ37	Uncharacterized protein, isoform B. (679 aa)
	A0A0R3NRU7	Uncharacterized protein, isoform C. (1212 aa)
	DpseGA19405	Nudix hydrolase domain-containing protein. (817 aa)
	DpseGA17939	C2H2-type domain-containing protein. (472 aa)
	DpseGA10231	Uncharacterized protein. (1410 aa)
	DpseGA21364	Uncharacterized protein. (121 aa)
	DpseGA19417	Ge1_WD40 domain-containing protein. (1391 aa)
	DpseGA16580	KH_dom_type_1 domain-containing protein. (232 aa)
	DpseGA13611	NOT2_3_5 domain-containing protein. (674 aa)
	DpseGA18459	Uncharacterized protein, isoform A. (952 aa)
	DpseGA10519	Uncharacterized protein, isoform A. (1063 aa)
	DpseGA21070	Uncharacterized protein, isoform A. (882 aa)
	DpseGA14273	Uncharacterized protein. (1292 aa)
	DpseGA10287	Uncharacterized protein. (421 aa)
	DpseGA17935	Uncharacterized protein. (456 aa)
	DpseGA12828	Uncharacterized protein, isoform A. (296 aa)
	DpseGA21908	RNase_PH domain-containing protein. (398 aa)
	DpseGA18065	Uncharacterized protein. (500 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NH54	DpseGA16600	A0A0R3NH54	A0A0R3P174	Polypyrimidine tract-binding protein 1.	Uncharacterized protein, isoform C.	0.458
A0A0R3NH54	DpseGA16847	A0A0R3NH54	Q29FJ8	Polypyrimidine tract-binding protein 1.	Uncharacterized protein.	0.480
A0A0R3NH54	DpseGA18065	A0A0R3NH54	Q29HA8	Polypyrimidine tract-binding protein 1.	Uncharacterized protein.	0.414
A0A0R3NH54	DpseGA22653	A0A0R3NH54	B5DLD4	Polypyrimidine tract-binding protein 1.	Uncharacterized protein, isoform A.	0.401
A0A0R3NH54	bru-3	A0A0R3NH54	A0A0R3P744	Polypyrimidine tract-binding protein 1.	Bruno-3, isoform AP.	0.633
A0A0R3NHQ7	B5DVU1	A0A0R3NHQ7	B5DVU1	CCR4-NOT transcription complex subunit 2.	CCR4-NOT transcription complex subunit 9.	0.911
A0A0R3NHQ7	DpseGA12828	A0A0R3NHQ7	Q29IU6	CCR4-NOT transcription complex subunit 2.	Uncharacterized protein, isoform A.	0.948
A0A0R3NHQ7	DpseGA13611	A0A0R3NHQ7	Q29KU3	CCR4-NOT transcription complex subunit 2.	NOT2_3_5 domain-containing protein.	0.902
A0A0R3NHQ7	DpseGA16600	A0A0R3NHQ7	A0A0R3P174	CCR4-NOT transcription complex subunit 2.	Uncharacterized protein, isoform C.	0.454
A0A0R3NHQ7	DpseGA19054	A0A0R3NHQ7	A0A0R3P6B5	CCR4-NOT transcription complex subunit 2.	Uncharacterized protein, isoform B.	0.963
A0A0R3NHQ7	DpseGA21070	A0A0R3NHQ7	Q29K24	CCR4-NOT transcription complex subunit 2.	Uncharacterized protein, isoform A.	0.990
A0A0R3NHQ7	I5ANY9	A0A0R3NHQ7	I5ANY9	CCR4-NOT transcription complex subunit 2.	CCR4-NOT transcription complex subunit 6.	0.822
A0A0R3NHQ7	N6W6M1	A0A0R3NHQ7	N6W6M1	CCR4-NOT transcription complex subunit 2.	CCR4-NOT transcription complex subunit 1.	0.991
A0A0R3NHQ7	Q28X67	A0A0R3NHQ7	Q28X67	CCR4-NOT transcription complex subunit 2.	Exosome complex component RRP42.	0.654
A0A0R3NHQ7	Q290A1	A0A0R3NHQ7	Q290A1	CCR4-NOT transcription complex subunit 2.	Uncharacterized protein.	0.925
A0A0R3NHQ7	Q297H9	A0A0R3NHQ7	Q297H9	CCR4-NOT transcription complex subunit 2.	DNA topoisomerase 2-associated protein PAT1.	0.958
A0A0R3NHQ7	Q29BS1	A0A0R3NHQ7	Q29BS1	CCR4-NOT transcription complex subunit 2.	CCR4-NOT transcription complex subunit 10.	0.932
A0A0R3NLP3	DpseGA17939	A0A0R3NLP3	Q2M0D3	Fragile X mental retardation protein.	C2H2-type domain-containing protein.	0.427
A0A0R3NLP3	DpseGA20942	A0A0R3NLP3	Q29EP7	Fragile X mental retardation protein.	Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.	0.426
A0A0R3NLP3	Q28ZU1	A0A0R3NLP3	Q28ZU1	Fragile X mental retardation protein.	Eukaryotic translation initiation factor 2C.	0.751