(25 nodes) Negative regulation of cell growth network (Drosophila pseudoobscura)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	DpseGA12197	Uncharacterized protein, isoform A. (859 aa)
	DpseGA14843	Uncharacterized protein, isoform C. (1417 aa)
	Dpse_Tl	Protein toll. (1120 aa)
	Sema-1a	Sema-1a, isoform D; Belongs to the semaphorin family. (854 aa)
	foxo	Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (644 aa)
	Q298J9	Uncharacterized protein, isoform A. (1107 aa)
	Q298B5	Forkhead box protein A2, hepatocyte nuclear factor 3-beta. (613 aa)
	Q297F4	YTH domain-containing family protein. (641 aa)
	Q291T4	Uncharacterized protein. (799 aa)
	Q28ZG4	Uncharacterized protein. (498 aa)
	Q28Z44	Uncharacterized protein, isoform A. (774 aa)
	Q28XZ4	Uncharacterized protein. (336 aa)
	I5APT4	Uncharacterized protein, isoform M. (1857 aa)
	B5DZT9	Uncharacterized protein, isoform A. (722 aa)
	DpseGA11040	Uncharacterized protein, isoform D. (1635 aa)
	DpseGA23503	Uncharacterized protein, isoform B. (1103 aa)
	DpseGA19047	Uncharacterized protein, isoform C. (503 aa)
	A0A0R3NLP3	Fragile X mental retardation protein. (702 aa)
	A0A0R3NEH1	Uncharacterized protein, isoform D. (1670 aa)
	GA17575	Protein ST7 homolog. (541 aa)
	DpseGA19997	Rap-GAP domain-containing protein. (1864 aa)
	DpseGA20508	BHLH domain-containing protein. (412 aa)
	DpseGA19294	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (305 aa)
	DpseGA12171	Uncharacterized protein, isoform A; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (340 aa)
	DpseGA12987	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (320 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NEH1	DpseGA19047	A0A0R3NEH1	A0A0R3NW51	Uncharacterized protein, isoform D.	Uncharacterized protein, isoform C.	0.523
A0A0R3NEH1	Q28XZ4	A0A0R3NEH1	Q28XZ4	Uncharacterized protein, isoform D.	Uncharacterized protein.	0.511
A0A0R3NEH1	Q298J9	A0A0R3NEH1	Q298J9	Uncharacterized protein, isoform D.	Uncharacterized protein, isoform A.	0.445
A0A0R3NEH1	foxo	A0A0R3NEH1	Q298W7	Uncharacterized protein, isoform D.	Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...]	0.652
B5DZT9	Sema-1a	B5DZT9	Q29JT4	Uncharacterized protein, isoform A.	Sema-1a, isoform D; Belongs to the semaphorin family.	0.458
DpseGA12171	DpseGA12987	Q29MV4	Q29I25	Uncharacterized protein, isoform A; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.908
DpseGA12171	DpseGA19294	Q29MV4	Q29MV5	Uncharacterized protein, isoform A; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.904
DpseGA12987	DpseGA12171	Q29I25	Q29MV4	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein, isoform A; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.908
DpseGA12987	DpseGA19294	Q29I25	Q29MV5	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.910
DpseGA19047	A0A0R3NEH1	A0A0R3NW51	A0A0R3NEH1	Uncharacterized protein, isoform C.	Uncharacterized protein, isoform D.	0.523
DpseGA19047	DpseGA19997	A0A0R3NW51	Q2M0Y0	Uncharacterized protein, isoform C.	Rap-GAP domain-containing protein.	0.649
DpseGA19047	Q298J9	A0A0R3NW51	Q298J9	Uncharacterized protein, isoform C.	Uncharacterized protein, isoform A.	0.582
DpseGA19047	foxo	A0A0R3NW51	Q298W7	Uncharacterized protein, isoform C.	Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...]	0.817
DpseGA19294	DpseGA12171	Q29MV5	Q29MV4	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein, isoform A; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.904
DpseGA19294	DpseGA12987	Q29MV5	Q29I25	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.910
DpseGA19997	DpseGA19047	Q2M0Y0	A0A0R3NW51	Rap-GAP domain-containing protein.	Uncharacterized protein, isoform C.	0.649
DpseGA19997	Q28ZG4	Q2M0Y0	Q28ZG4	Rap-GAP domain-containing protein.	Uncharacterized protein.	0.471
DpseGA19997	Q298J9	Q2M0Y0	Q298J9	Rap-GAP domain-containing protein.	Uncharacterized protein, isoform A.	0.999
DpseGA19997	foxo	Q2M0Y0	Q298W7	Rap-GAP domain-containing protein.	Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...]	0.568
Q28XZ4	A0A0R3NEH1	Q28XZ4	A0A0R3NEH1	Uncharacterized protein.	Uncharacterized protein, isoform D.	0.511