(90 nodes) Regulation of cell migration network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DpseGA12050	Uncharacterized protein, isoform B. (2127 aa)
	Sema-1a	Sema-1a, isoform D; Belongs to the semaphorin family. (854 aa)
	DpseGA10287	Uncharacterized protein. (421 aa)
	DpseGA17762	Uncharacterized protein, isoform A. (949 aa)
	DpseGA15506	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (748 aa)
	DpseGA16523	Uncharacterized protein. (492 aa)
	DpseGA18914	Uncharacterized protein. (1569 aa)
	DpseGA16373	Uncharacterized protein, isoform A. (745 aa)
	DpseGA18692	Uncharacterized protein, isoform A. (450 aa)
	DpseGA10324	Uncharacterized protein. (448 aa)
	DpseGA12522	Uncharacterized protein. (362 aa)
	DpseGA17619	Uncharacterized protein, isoform D. (5833 aa)
	DpseGA20137	Uncharacterized protein. (1263 aa)
	DpseGA19660	Uncharacterized protein, isoform A. (683 aa)
	DpseGA20050	Uncharacterized protein, isoform A. (889 aa)
	DpseGA14605	LRRNT domain-containing protein. (463 aa)
	DpseGA10461	UBIQUITIN_CONJUGAT_2 domain-containing protein. (165 aa)
	DpseGA18669	WD_REPEATS_REGION domain-containing protein. (427 aa)
	DpseGA16736	Uncharacterized protein, isoform A. (326 aa)
	A0A0R3NEH1	Uncharacterized protein, isoform D. (1670 aa)
	A0A0R3NM36	Leucine-rich repeat-containing protein 16. (1515 aa)
	A0A0R3NMX6	Uncharacterized protein, isoform A. (815 aa)
	A0A0R3NP70	DnaJ homolog subfamily C member 13. (2409 aa)
	Dpse_Dscam	Dscam, isoform B. (2049 aa)
	DpseGA12523	Uncharacterized protein, isoform E. (694 aa)
	A0A0R3NSV7	MAP/microtubule affinity-regulating kinase. (1192 aa)
	DpseGA20908	Receptor protein-tyrosine kinase. (1649 aa)
	DpseGA19047	Uncharacterized protein, isoform C. (503 aa)
	DpseGA19056	IRS-type PTB domain-containing protein. (272 aa)
	DpseGA23031	Integrin beta; Belongs to the integrin beta chain family. (856 aa)
	DpseGA26435	Uncharacterized protein, isoform C. (1782 aa)
	DpseGA32841	Uncharacterized protein. (279 aa)
	DpseGA23680	Uncharacterized protein, isoform C. (439 aa)
	DpseGA23503	Uncharacterized protein, isoform B. (1103 aa)
	DpseGA16623	Uncharacterized protein, isoform G. (2553 aa)
	DpseGA25451	Uncharacterized protein, isoform A. (316 aa)
	DpseGA28085	Uncharacterized protein, isoform B. (241 aa)
	DpseGA22607	Uncharacterized protein, isoform A. (1248 aa)
	small-wing	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1250 aa)
	DpseGA24328	Uncharacterized protein. (1561 aa)
	DpseGA23659	Uncharacterized protein. (343 aa)
	DpseGA28732	Uncharacterized protein. (207 aa)
	B5DX68	F-box and WD-40 domain protein 1/11. (590 aa)
	B5DX82	Uncharacterized protein, isoform B. (800 aa)
	Dpse_Ama	Ama. (329 aa)
	B5DYR5	Insulin-like growth factor 1 receptor. (2293 aa)
	B5DZ84	Uncharacterized protein, isoform A. (205 aa)
	B5DZT9	Uncharacterized protein, isoform A. (722 aa)
	B5E0W7	Ras-related protein Rap-2C. (182 aa)
	B5E1G4	Uncharacterized protein, isoform A. (1517 aa)
	B5E1J5	Uncharacterized protein, isoform A. (424 aa)
	B5E1M2	Uncharacterized protein, isoform B. (325 aa)
	I5ANT7	Dedicator of cytokinesis protein 1. (2003 aa)
	N6WCZ8	Uncharacterized protein. (2217 aa)
	Q28WU5	CCAAT/enhancer binding protein (C/EBP), invertebrate. (455 aa)
	Q28XC4	Uncharacterized protein. (696 aa)
	Q28XM9	Uncharacterized protein, isoform A. (1439 aa)
	Q28XS1	Uncharacterized protein, isoform A. (1058 aa)
	Q28Y68	Uncharacterized protein. (1299 aa)
	Q28YH3	Paired amphipathic helix protein Sin3a. (2143 aa)
	Q28Z44	Uncharacterized protein, isoform A. (774 aa)
	Q28Z58	Origin recognition complex subunit 3. (713 aa)
	vir	Protein virilizer; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Required for proper inclusion of regulated exons in Ubx trans [...] (1849 aa)
	Q291N2	Uncharacterized protein, isoform A. (1136 aa)
	Q291P5	Roundabout, axon guidance receptor 2. (1398 aa)
	Q291T4	Uncharacterized protein. (799 aa)
	Q293L2	Uncharacterized protein, isoform A. (751 aa)
	Q293W0	Uncharacterized protein, isoform A. (800 aa)
	Q294V1	RAC serine/threonine-protein kinase. (530 aa)
	Q296A7	Katanin p60 ATPase-containing subunit A1. (582 aa)
	Dpse_ttk	Tramtrack, isoform F. (829 aa)
	Q299A1	Dual specificity phosphatase 10. (489 aa)
	Q299B9	Uncharacterized protein, isoform A. (531 aa)
	Q29AY5	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta. (1112 aa)
	DpseGA14409	Sema domain-containing protein. (2071 aa)
	DpseGA10747	Sema domain-containing protein. (1636 aa)
	DpseGA19306	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (180 aa)
	DpseGA10085	BH4_AAA_HYDROXYL_2 domain-containing protein. (575 aa)
	DpseGA10349	Uncharacterized protein. (637 aa)
	DpseGA20413	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1212 aa)
	DpseGA20834	Uncharacterized protein, isoform C. (1380 aa)
	DpseGA11530	Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (976 aa)
	DpseGA15321	Uncharacterized protein. (192 aa)
	DpseGA13403	Uncharacterized protein, isoform A. (795 aa)
	DpseGA10179	Uncharacterized protein. (3708 aa)
	DpseGA20104	Uncharacterized protein, isoform A; Belongs to the PDGF/VEGF growth factor family. (323 aa)
	DpseGA17546	Uncharacterized protein, isoform A. (174 aa)
	DpseGA17933	Uncharacterized protein, isoform A. (618 aa)
	DpseGA11164	Uncharacterized protein, isoform A. (786 aa)
	DpseGA11481	Uncharacterized protein. (1960 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NEH1	DpseGA12050	A0A0R3NEH1	Q29JR0	Uncharacterized protein, isoform D.	Uncharacterized protein, isoform B.	0.692
A0A0R3NEH1	DpseGA19047	A0A0R3NEH1	A0A0R3NW51	Uncharacterized protein, isoform D.	Uncharacterized protein, isoform C.	0.523
A0A0R3NEH1	Q28XM9	A0A0R3NEH1	Q28XM9	Uncharacterized protein, isoform D.	Uncharacterized protein, isoform A.	0.600
A0A0R3NEH1	Q294V1	A0A0R3NEH1	Q294V1	Uncharacterized protein, isoform D.	RAC serine/threonine-protein kinase.	0.627
A0A0R3NEH1	Q29AY5	A0A0R3NEH1	Q29AY5	Uncharacterized protein, isoform D.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.	0.457
A0A0R3NMX6	Q291P5	A0A0R3NMX6	Q291P5	Uncharacterized protein, isoform A.	Roundabout, axon guidance receptor 2.	0.417
A0A0R3NP70	DpseGA14605	A0A0R3NP70	Q2LYW7	DnaJ homolog subfamily C member 13.	LRRNT domain-containing protein.	0.426
B5DX68	Q294V1	B5DX68	Q294V1	F-box and WD-40 domain protein 1/11.	RAC serine/threonine-protein kinase.	0.576
B5DX82	DpseGA20050	B5DX82	Q2LYL3	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.463
B5DX82	Q28XC4	B5DX82	Q28XC4	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.680
B5DX82	Q293L2	B5DX82	Q293L2	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.838
B5DX82	Q29AY5	B5DX82	Q29AY5	Uncharacterized protein, isoform B.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.	0.506
B5DX82	small-wing	B5DX82	B5DNH4	Uncharacterized protein, isoform B.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.545
B5DYR5	DpseGA19047	B5DYR5	A0A0R3NW51	Insulin-like growth factor 1 receptor.	Uncharacterized protein, isoform C.	0.609
B5DYR5	DpseGA19056	B5DYR5	A0A0R3NWK0	Insulin-like growth factor 1 receptor.	IRS-type PTB domain-containing protein.	0.998
B5DYR5	DpseGA20050	B5DYR5	Q2LYL3	Insulin-like growth factor 1 receptor.	Uncharacterized protein, isoform A.	0.944
B5DYR5	Q28XM9	B5DYR5	Q28XM9	Insulin-like growth factor 1 receptor.	Uncharacterized protein, isoform A.	0.941
B5DYR5	Q29AY5	B5DYR5	Q29AY5	Insulin-like growth factor 1 receptor.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.	0.958
B5DZ84	B5DZT9	B5DZ84	B5DZT9	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.426
B5DZ84	B5E0W7	B5DZ84	B5E0W7	Uncharacterized protein, isoform A.	Ras-related protein Rap-2C.	0.470