(108 nodes) Signaling receptor activator activity network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Q296X7	Uncharacterized protein, isoform A. (899 aa)
	B5E199	Uncharacterized protein. (72 aa)
	B5E0Z6	Uncharacterized protein. (122 aa)
	B5E0V6	Uncharacterized protein, isoform C. (193 aa)
	B5DZT9	Uncharacterized protein, isoform A. (722 aa)
	Acp32CD	Acp32CD. (352 aa)
	DpseGA25451	Uncharacterized protein, isoform A. (316 aa)
	DpseGA25435	Fibrinogen C-terminal domain-containing protein. (408 aa)
	DpseGA12316	Uncharacterized protein. (177 aa)
	DpseGA19609	Uncharacterized protein. (211 aa)
	DpseGA19821	IlGF domain-containing protein. (141 aa)
	DpseGA12803	IlGF domain-containing protein. (145 aa)
	DpseGA14605	LRRNT domain-containing protein. (463 aa)
	DpseGA11673	Uncharacterized protein. (146 aa)
	DpseGA12522	Uncharacterized protein. (362 aa)
	DpseGA18562	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (499 aa)
	DpseGA18561	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (415 aa)
	wg	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (468 aa)
	DpseGA12459	Uncharacterized protein, isoform A. (197 aa)
	DpseGA16409	Uncharacterized protein. (751 aa)
	DpseGA20105	Spaetzle domain-containing protein. (631 aa)
	DpseGA20106	Uncharacterized protein. (161 aa)
	DpseGA13352	Uncharacterized protein, isoform A. (121 aa)
	DpseGA13357	Uncharacterized protein, isoform A. (615 aa)
	DpseGA16378	Uncharacterized protein, isoform A. (1306 aa)
	sNPF	sNPF-associated peptide; Plays a role in controlling food intake and regulating body size; Belongs to the NPY family. (290 aa)
	Sema-1a	Sema-1a, isoform D; Belongs to the semaphorin family. (854 aa)
	DpseGA16402	TGF_BETA_2 domain-containing protein. (386 aa)
	DpseGA15301	Uncharacterized protein, isoform C. (669 aa)
	DpseGA21878	FOG_N domain-containing protein. (637 aa)
	DpseGA20104	Uncharacterized protein, isoform A; Belongs to the PDGF/VEGF growth factor family. (323 aa)
	DpseGA19283	Uncharacterized protein. (539 aa)
	DpseGA14719	Uncharacterized protein, isoform A. (324 aa)
	DpseGA14888	Uncharacterized protein. (286 aa)
	DpseGA11479	Uncharacterized protein, isoform A. (184 aa)
	DpseGA12013	Uncharacterized protein. (90 aa)
	DpseGA16783	Uncharacterized protein. (452 aa)
	DpseGA10349	Uncharacterized protein. (637 aa)
	DpseGA22158	Uncharacterized protein, isoform A. (395 aa)
	DpseGA11153	Uncharacterized protein. (83 aa)
	DpseGA19010	Uncharacterized protein. (228 aa)
	DpseGA14914	TGF_BETA_2 domain-containing protein. (617 aa)
	DpseGA10734	Uncharacterized protein, isoform A. (959 aa)
	DpseGA12740	Uncharacterized protein. (105 aa)
	DpseGA19569	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (612 aa)
	DpseGA15119	Uncharacterized protein, isoform A. (755 aa)
	capa	Cardio acceleratory peptide 2b; CAP-1 and CAP-2, but not CAP-3 are ligands for the Capa receptor. CAP-1 and CAP-2 are probably components of the signal transduction pathway that leads to Malpighian tubule fluid secretion via the second messenger nitric oxide (By similarity). Belongs to the pyrokinin family. (155 aa)
	Q29BS6	Uncharacterized protein. (193 aa)
	npf	Neuropeptide F; An integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. May have a hormonal role in females (By similarity); Belongs to the NPY family. (102 aa)
	Q29AR9	Uncharacterized protein. (173 aa)
	Q29AR5	Uncharacterized protein, isoform A. (357 aa)
	Q29AD5	Uncharacterized protein, isoform O. (403 aa)
	hh-1	Protein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu) (By similarity). The hedgehog protein C-product, which mediates the autocatalytic activity, [...] (481 aa)
	Q29A86	Uncharacterized protein. (96 aa)
	Q29A26	Uncharacterized protein, isoform A. (136 aa)
	Q29A13	Wingless-type MMTV integration site family, member 8. (391 aa)
	Crz	Corazonin precursor-related peptide; Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat. Clock (Clk) and cycle (cyc) proteins negatively regulate Crz transcription in a cell-specific manner (By similarity). (161 aa)
	Q298P6	Uncharacterized protein. (97 aa)
	Q297C5	Uncharacterized protein. (100 aa)
	Dsk	Drosulfakinin-0; Drosulfakinin-0 (DSK 0) plays diverse biological roles including regulating gut muscle contraction in adults but not in larvae; Belongs to the gastrin/cholecystokinin family. (139 aa)
	Q293P0	Uncharacterized protein. (852 aa)
	Q293L2	Uncharacterized protein, isoform A. (751 aa)
	Q292R9	Bone morphogenetic protein 7. (459 aa)
	Q292A5	Uncharacterized protein. (670 aa)
	Q291T4	Uncharacterized protein. (799 aa)
	Q28ZW1	Uncharacterized protein. (574 aa)
	Q28Z90	Uncharacterized protein, isoform A. (496 aa)
	Q28Z44	Uncharacterized protein, isoform A. (774 aa)
	Q28Z25	Uncharacterized protein. (206 aa)
	Q28Z12	Uncharacterized protein. (432 aa)
	Q28Z02	Uncharacterized protein. (353 aa)
	Q28XC7	Uncharacterized protein. (773 aa)
	Q28XC4	Uncharacterized protein. (696 aa)
	Sry-alpha	Serendipity locus protein alpha; Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions (By similarity). (551 aa)
	dpp	Protein decapentaplegic; Acts as an extracellular morphogen to establish at least two cellular response thresholds within the dorsal half of the drosophila embryo. Required for the proper development of the embryonic dorsal hypoderm, for viability of larvae and for cell viability of the epithelial cells in the imaginal disks. Acts together with scw (By similarity); Belongs to the TGF-beta family. (616 aa)
	B5E1J5	Uncharacterized protein, isoform A. (424 aa)
	DpseGA28085	Uncharacterized protein, isoform B. (241 aa)
	DpseGA26052	Uncharacterized protein. (67 aa)
	DpseGA25646	Uncharacterized protein. (197 aa)
	B5DWT5	Uncharacterized protein. (1390 aa)
	B5DVY0	Uncharacterized protein, isoform B. (307 aa)
	DpseGA22214	Uncharacterized protein. (121 aa)
	DpseGA28721	MNNL domain-containing protein. (102 aa)
	DpseGA28732	Uncharacterized protein. (207 aa)
	B5DYM4	Uncharacterized protein. (214 aa)
	Dpse_Ama	Ama. (329 aa)
	DpseGA22236	Uncharacterized protein. (122 aa)
	DpseGA23862	IlGF domain-containing protein. (130 aa)
	DpseGA23860	IlGF domain-containing protein. (188 aa)
	DpseGA22327	Uncharacterized protein. (382 aa)
	DpseGA28476	Uncharacterized protein. (838 aa)
	DpseGA28100	Fibrinogen C-terminal domain-containing protein. (93 aa)
	A0A0R3NG32	Uncharacterized protein. (1222 aa)
	A0A0R3NKF3	Uncharacterized protein, isoform A. (158 aa)
	A0A0R3NPB6	Wingless-type MMTV integration site family, member 7. (384 aa)
	A0A0R3NQ45	Uncharacterized protein, isoform B. (158 aa)
	DpseGA12042	Uncharacterized protein, isoform C. (148 aa)
	DpseGA12523	Uncharacterized protein, isoform E. (694 aa)
	DpseGA25881	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (543 aa)
	DpseGA13354	Uncharacterized protein, isoform B. (281 aa)
	A0A0R3NVX0	Uncharacterized protein. (346 aa)
	DpseGA22237	Uncharacterized protein, isoform E. (457 aa)
	DpseGA32601	Fibrinogen C-terminal domain-containing protein. (186 aa)
	DpseGA12198	Uncharacterized protein, isoform B. (232 aa)
	DpseGA19279	Uncharacterized protein, isoform B. (438 aa)
	DpseGA12640	Uncharacterized protein, isoform B. (189 aa)
	DpseGA23503	Uncharacterized protein, isoform B. (1103 aa)
	DpseGA16736	Uncharacterized protein, isoform A. (326 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NG32	B5DWT5	A0A0R3NG32	B5DWT5	Uncharacterized protein.	Uncharacterized protein.	0.900
A0A0R3NG32	DpseGA28721	A0A0R3NG32	B5DUT0	Uncharacterized protein.	MNNL domain-containing protein.	0.430
A0A0R3NG32	Q293P0	A0A0R3NG32	Q293P0	Uncharacterized protein.	Uncharacterized protein.	0.618
A0A0R3NKF3	B5DVY0	A0A0R3NKF3	B5DVY0	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform B.	0.418
A0A0R3NKF3	DpseGA11153	A0A0R3NKF3	Q29D82	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.493
A0A0R3NKF3	DpseGA12316	A0A0R3NKF3	Q2LZS6	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.477
A0A0R3NKF3	DpseGA13352	A0A0R3NKF3	Q29M48	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.528
A0A0R3NKF3	npf	A0A0R3NKF3	Q29B55	Uncharacterized protein, isoform A.	Neuropeptide F; An integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. May have a hormonal role in females (By similarity); Belongs to the NPY family.	0.454
A0A0R3NKF3	sNPF	A0A0R3NKF3	Q29KK2	Uncharacterized protein, isoform A.	sNPF-associated peptide; Plays a role in controlling food intake and regulating body size; Belongs to the NPY family.	0.551
A0A0R3NPB6	DpseGA25881	A0A0R3NPB6	A0A0R3NRN4	Wingless-type MMTV integration site family, member 7.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.411
A0A0R3NQ45	DpseGA20105	A0A0R3NQ45	Q29MB4	Uncharacterized protein, isoform B.	Spaetzle domain-containing protein.	0.413
A0A0R3NQ45	Q29A86	A0A0R3NQ45	Q29A86	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.445
A0A0R3NQ45	Q29AD5	A0A0R3NQ45	Q29AD5	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform O.	0.483
A0A0R3NQ45	Q29AR9	A0A0R3NQ45	Q29AR9	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.562
A0A0R3NQ45	sNPF	A0A0R3NQ45	Q29KK2	Uncharacterized protein, isoform B.	sNPF-associated peptide; Plays a role in controlling food intake and regulating body size; Belongs to the NPY family.	0.416
B5DVY0	A0A0R3NKF3	B5DVY0	A0A0R3NKF3	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.418
B5DVY0	B5E199	B5DVY0	B5E199	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.475
B5DVY0	Crz	B5DVY0	Q299B0	Uncharacterized protein, isoform B.	Corazonin precursor-related peptide; Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat. Clock (Clk) and cycle (cyc) proteins negatively regulate Crz transcription in a cell-specific manner (By similarity).	0.405
B5DVY0	DpseGA12042	B5DVY0	A0A0R3NQT0	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform C.	0.420
B5DVY0	DpseGA12316	B5DVY0	Q2LZS6	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.542