(35 nodes) Oocyte fate determination network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	spn-E	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...] (1433 aa)
	A0A0R3NLC9	Uncharacterized protein, isoform I. (2060 aa)
	A0A0R3NLP3	Fragile X mental retardation protein. (702 aa)
	A0A0R3NN44	Uncharacterized protein, isoform A. (8901 aa)
	A0A0R3NP93	annotation not available (982 aa)
	A0A0R3NSV7	MAP/microtubule affinity-regulating kinase. (1192 aa)
	A0A0R3NU81	Uncharacterized protein, isoform B. (248 aa)
	DpseGA18624	Uncharacterized protein, isoform C. (1562 aa)
	DpseGA15168	Uncharacterized protein, isoform C. (2464 aa)
	DpseGA20400	Uncharacterized protein, isoform B. (4663 aa)
	DpseGA25116	Uncharacterized protein. (799 aa)
	DpseGA22759	Uncharacterized protein, isoform A; Belongs to the 14-3-3 family. (250 aa)
	DpseGA26566	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2517 aa)
	B5E1F0	Exonuclease 3'-5' domain-containing protein 1. (1013 aa)
	DpseGA13651	Uncharacterized protein. (486 aa)
	Q28X29	Capping protein (actin filament) muscle Z-line, alpha. (286 aa)
	Q28Y04	Uncharacterized protein. (244 aa)
	Q28YB7	Uncharacterized protein. (1292 aa)
	Q28ZB8	Uncharacterized protein. (165 aa)
	Q28ZU1	Eukaryotic translation initiation factor 2C. (985 aa)
	Lis-1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. (411 aa)
	Q296W0	Uncharacterized protein, isoform A. (262 aa)
	Q297R3	Microprocessor complex subunit DGCR8. (667 aa)
	Q297V2	DNA-repair protein XRCC3. (348 aa)
	Q29AC3	Uncharacterized protein. (254 aa)
	Q29AU1	Uncharacterized protein. (2280 aa)
	Q29C69	DNA repair protein RAD51. (335 aa)
	DpseGA19370	Uncharacterized protein; Belongs to the argonaute family. (848 aa)
	DpseGA21197	Uncharacterized protein, isoform C. (1163 aa)
	DpseGA20732	Uncharacterized protein, isoform A. (1052 aa)
	DpseGA17620	Uncharacterized protein, isoform A. (973 aa)
	okr	DNA repair and recombination protein RAD54-like; Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54 (By similarity). (782 aa)
	DpseGA20081	Uncharacterized protein, isoform A. (871 aa)
	DpseGA20827	NUDE_C domain-containing protein. (382 aa)
	DpseGA10596	Uncharacterized protein. (2000 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NLP3	Q28YB7	A0A0R3NLP3	Q28YB7	Fragile X mental retardation protein.	Uncharacterized protein.	0.578
A0A0R3NLP3	Q28ZU1	A0A0R3NLP3	Q28ZU1	Fragile X mental retardation protein.	Eukaryotic translation initiation factor 2C.	0.751
A0A0R3NLP3	Q297R3	A0A0R3NLP3	Q297R3	Fragile X mental retardation protein.	Microprocessor complex subunit DGCR8.	0.540
A0A0R3NLP3	Q29AU1	A0A0R3NLP3	Q29AU1	Fragile X mental retardation protein.	Uncharacterized protein.	0.607
A0A0R3NN44	DpseGA15168	A0A0R3NN44	A0A0R3P5T5	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform C.	0.648
A0A0R3NP93	A0A0R3NSV7	A0A0R3NP93	A0A0R3NSV7	annotation not available	MAP/microtubule affinity-regulating kinase.	0.593
A0A0R3NP93	DpseGA18624	A0A0R3NP93	A0A0R3NZI7	annotation not available	Uncharacterized protein, isoform C.	0.995
A0A0R3NSV7	A0A0R3NP93	A0A0R3NSV7	A0A0R3NP93	MAP/microtubule affinity-regulating kinase.	annotation not available	0.593
A0A0R3NSV7	A0A0R3NU81	A0A0R3NSV7	A0A0R3NU81	MAP/microtubule affinity-regulating kinase.	Uncharacterized protein, isoform B.	0.611
A0A0R3NSV7	DpseGA18624	A0A0R3NSV7	A0A0R3NZI7	MAP/microtubule affinity-regulating kinase.	Uncharacterized protein, isoform C.	0.495
A0A0R3NSV7	DpseGA22759	A0A0R3NSV7	B5DKW8	MAP/microtubule affinity-regulating kinase.	Uncharacterized protein, isoform A; Belongs to the 14-3-3 family.	0.611
A0A0R3NSV7	Q296W0	A0A0R3NSV7	Q296W0	MAP/microtubule affinity-regulating kinase.	Uncharacterized protein, isoform A.	0.611
A0A0R3NU81	A0A0R3NSV7	A0A0R3NU81	A0A0R3NSV7	Uncharacterized protein, isoform B.	MAP/microtubule affinity-regulating kinase.	0.611
A0A0R3NU81	DpseGA18624	A0A0R3NU81	A0A0R3NZI7	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform C.	0.465
A0A0R3NU81	DpseGA22759	A0A0R3NU81	B5DKW8	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A; Belongs to the 14-3-3 family.	0.938
A0A0R3NU81	Lis-1	A0A0R3NU81	Q291L9	Uncharacterized protein, isoform B.	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.	0.623
A0A0R3NU81	Q296W0	A0A0R3NU81	Q296W0	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.937
B5E1F0	DpseGA25116	B5E1F0	B5DJ67	Exonuclease 3'-5' domain-containing protein 1.	Uncharacterized protein.	0.884
B5E1F0	spn-E	B5E1F0	Q296Q5	Exonuclease 3'-5' domain-containing protein 1.	Probable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repres [...]	0.422
DpseGA13651	DpseGA17620	I5AMP9	Q29FQ4	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.935