(53 nodes) Cortical actin cytoskeleton organization network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A0R3NH46	Uncharacterized protein, isoform A. (478 aa)
	A0A0R3NHI5	Uncharacterized protein, isoform A. (2503 aa)
	A0A0R3NI42	Uncharacterized protein, isoform D. (2255 aa)
	A0A0R3NJY1	annotation not available (299 aa)
	A0A0R3NN99	Uncharacterized protein, isoform A. (1430 aa)
	A0A0R3NPG2	Guanine nucleotide-binding protein G(o) subunit alpha. (354 aa)
	DpseGA18320	Uncharacterized protein, isoform C. (678 aa)
	DpseGA12621	Uncharacterized protein, isoform B. (1091 aa)
	DpseGA16623	Uncharacterized protein, isoform G. (2553 aa)
	DpseGA16706	Uncharacterized protein, isoform E. (1186 aa)
	DpseGA25172	Uncharacterized protein. (567 aa)
	DpseGA25765	Uncharacterized protein. (296 aa)
	DpseGA25958	Protein kinase domain-containing protein. (385 aa)
	DpseGA22589	Uncharacterized protein. (224 aa)
	DpseGA28117	GED domain-containing protein. (167 aa)
	B5DVF9	Synaptotagmin-like protein. (4047 aa)
	B5DZ84	Uncharacterized protein, isoform A. (205 aa)
	I5AN24	Uncharacterized protein, isoform B. (1581 aa)
	N6W683	Uncharacterized protein, isoform A. (1250 aa)
	Q28WU9	Uncharacterized protein, isoform H. (1649 aa)
	Q28ZF8	Actin-binding protein anillin. (1579 aa)
	Q28ZZ9	Uncharacterized protein. (148 aa)
	Q294Z3	Uncharacterized protein, isoform A. (1978 aa)
	Q295Q4	Uncharacterized protein, isoform A. (619 aa)
	Q296V6	Ras-related protein Rab-11A. (214 aa)
	Q296Z3	Exocyst complex component 8. (682 aa)
	Q298J2	Adenomatosis polyposis coli protein. (1088 aa)
	Sra-1	Cytoplasmic FMR1-interacting protein; Plays a role in guidance and morphology of central and peripheral axons and in synaptic morphology. Also required for formation of cell membrane protrusions and for bristle development (By similarity). (1291 aa)
	Q29AJ9	Baculoviral IAP repeat-containing protein 5. (201 aa)
	Q29BK4	Elongation of very long chain fatty acids protein 7. (321 aa)
	Q29C94	Conserved oligomeric Golgi complex subunit 7. (742 aa)
	DpseGA11700	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (887 aa)
	DpseGA11104	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family. (1890 aa)
	DpseGA19168	Uncharacterized protein. (1124 aa)
	DpseGA16627	Uncharacterized protein. (82 aa)
	DpseGA20834	Uncharacterized protein, isoform C. (1380 aa)
	DpseGA20022	Uncharacterized protein, isoform A; Belongs to the PI3/PI4-kinase family. (1802 aa)
	DpseGA15321	Uncharacterized protein. (192 aa)
	DpseGA10039	Uncharacterized protein. (355 aa)
	DpseGA21237	Uncharacterized protein, isoform A. (645 aa)
	Cdc42	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity). (191 aa)
	DpseGA22026	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1388 aa)
	moody	G-protein coupled receptor moody; Required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug-related behaviors (By similarity); Belongs to the G-protein coupled receptor 1 family. (675 aa)
	DpseGA10664	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (301 aa)
	DpseGA19678	Uncharacterized protein. (755 aa)
	DpseGA15375	Uncharacterized protein. (1311 aa)
	DpseGA14608	Uncharacterized protein, isoform A. (1097 aa)
	DpseGA21874	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	DpseGA21553	Myotubularin phosphatase domain-containing protein. (619 aa)
	DpseGA19270	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
	DpseGA19405	Nudix hydrolase domain-containing protein. (817 aa)
	DpseGA10369	Uncharacterized protein. (1855 aa)
	DpseGA11545	Uncharacterized protein. (601 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NH46	B5DZ84	A0A0R3NH46	B5DZ84	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.504
A0A0R3NH46	Cdc42	A0A0R3NH46	Q29HY3	Uncharacterized protein, isoform A.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	0.605
A0A0R3NH46	DpseGA10369	A0A0R3NH46	Q2M0M0	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.441
A0A0R3NH46	DpseGA10664	A0A0R3NH46	Q29KS9	Uncharacterized protein, isoform A.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.750
A0A0R3NH46	DpseGA14608	A0A0R3NH46	Q29LX2	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.586
A0A0R3NH46	DpseGA15321	A0A0R3NH46	Q29EV6	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.605
A0A0R3NH46	DpseGA18320	A0A0R3NH46	A0A0R3NVX7	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform C.	0.982
A0A0R3NH46	DpseGA19168	A0A0R3NH46	Q29E13	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.990
A0A0R3NH46	DpseGA19270	A0A0R3NH46	Q29PP8	Uncharacterized protein, isoform A.	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.	0.658
A0A0R3NH46	Sra-1	A0A0R3NH46	Q299G2	Uncharacterized protein, isoform A.	Cytoplasmic FMR1-interacting protein; Plays a role in guidance and morphology of central and peripheral axons and in synaptic morphology. Also required for formation of cell membrane protrusions and for bristle development (By similarity).	0.987
A0A0R3NHI5	B5DZ84	A0A0R3NHI5	B5DZ84	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.840
A0A0R3NHI5	Cdc42	A0A0R3NHI5	Q29HY3	Uncharacterized protein, isoform A.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	0.471
A0A0R3NHI5	DpseGA15321	A0A0R3NHI5	Q29EV6	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.471
A0A0R3NI42	Cdc42	A0A0R3NI42	Q29HY3	Uncharacterized protein, isoform D.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	0.536
A0A0R3NN99	B5DZ84	A0A0R3NN99	B5DZ84	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.716
A0A0R3NN99	Cdc42	A0A0R3NN99	Q29HY3	Uncharacterized protein, isoform A.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	0.474
A0A0R3NN99	DpseGA15321	A0A0R3NN99	Q29EV6	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.474
A0A0R3NN99	DpseGA15375	A0A0R3NN99	Q29LW0	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.464
A0A0R3NN99	Q28WU9	A0A0R3NN99	Q28WU9	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform H.	0.491
A0A0R3NN99	Q296V6	A0A0R3NN99	Q296V6	Uncharacterized protein, isoform A.	Ras-related protein Rab-11A.	0.863