(86 nodes) RNA 3-end processing network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DpseGA20147	Uncharacterized protein, isoform A. (676 aa)
	Q290G0	Uncharacterized protein. (763 aa)
	Q290A0	Integrator complex subunit 1. (2073 aa)
	Pabp2	Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity). (225 aa)
	cbc	Protein CLP1 homolog; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation; Belongs to the Clp1 family. Clp1 subfamily. (425 aa)
	Q28ZE6	Exosome complex component RRP4. (298 aa)
	Q28YL2	Uncharacterized protein. (262 aa)
	Q28YF4	Uncharacterized protein. (872 aa)
	Q28XK5	Uncharacterized protein. (147 aa)
	CycC	Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase Cdk8 that phosphoryla [...] (267 aa)
	Q29AI2	Exosome complex exonuclease RRP6. (905 aa)
	Q29AM1	Exosome complex component RRP46. (234 aa)
	Q29AN7	Integrator complex subunit 11. (597 aa)
	Q29B98	Integrator complex subunit 12. (340 aa)
	Q29BB6	Polyribonucleotide nucleotidyltransferase. (769 aa)
	DpseGA21025	Exonuclease domain-containing protein. (744 aa)
	DpseGA18300	PPR_long domain-containing protein. (707 aa)
	DpseGA20165	Uncharacterized protein, isoform A. (649 aa)
	DpseGA11407	Uncharacterized protein. (1025 aa)
	DpseGA16124	VWFA domain-containing protein. (444 aa)
	DpseGA10875	Uncharacterized protein. (1160 aa)
	DpseGA11366	Uncharacterized protein, isoform A. (626 aa)
	DpseGA21908	RNase_PH domain-containing protein. (398 aa)
	DpseGA10992	Uncharacterized protein. (630 aa)
	DpseGA20902	Uncharacterized protein. (1132 aa)
	DpseGA13761	RNase_PH domain-containing protein. (249 aa)
	DpseGA18430	VWFA domain-containing protein. (582 aa)
	DpseGA16580	KH_dom_type_1 domain-containing protein. (232 aa)
	DpseGA10231	Uncharacterized protein. (1410 aa)
	DpseGA21642	Uncharacterized protein, isoform A. (625 aa)
	Q291E2	Cleavage and polyadenylation specificity factor subunit 1. (1459 aa)
	DpseGA21481	CID domain-containing protein. (381 aa)
	DpseGA20773	RNase_PH domain-containing protein. (331 aa)
	DpseGA18747	Beta-Casp domain-containing protein. (657 aa)
	Q28X67	Exosome complex component RRP42. (296 aa)
	Q28X10	Uncharacterized protein, isoform A. (1362 aa)
	N6WBX7	Uncharacterized protein, isoform A. (251 aa)
	DpseGA17582	Uncharacterized protein. (282 aa)
	I5AP92	Uncharacterized protein. (327 aa)
	I5ANR3	Poly(A) RNA polymerase GLD2. (1233 aa)
	I5AN96	Uncharacterized protein. (392 aa)
	B5E0L4	Uncharacterized protein. (281 aa)
	B5E0E7	Uncharacterized protein. (352 aa)
	B5DZX5	Uncharacterized protein, isoform A. (264 aa)
	B5DZN8	RRNA 2'-O-methyltransferase fibrillarin. (342 aa)
	B5DZ83	H/ACA ribonucleoprotein complex subunit 4. (601 aa)
	B5DYN4	Integrator complex subunit 7. (1000 aa)
	B5DYG6	Cleavage and polyadenylation specificity factor subunit 2. (699 aa)
	B5DXG7	Pre-mRNA 3'-end-processing factor FIP1. (686 aa)
	B5DXF2	Poly(A) RNA polymerase, mitochondrial. (327 aa)
	DpseGA23278	Exonuclease domain-containing protein. (223 aa)
	DpseGA23277	Uncharacterized protein, isoform A. (223 aa)
	DpseGA23279	Exonuclease domain-containing protein. (223 aa)
	DpseGA27679	Uncharacterized protein. (996 aa)
	DpseGA27855	Uncharacterized protein, isoform A. (92 aa)
	DpseGA23201	HTH La-type RNA-binding domain-containing protein. (167 aa)
	DpseGA23999	INT_SG_DDX_CT_C domain-containing protein. (866 aa)
	DpseGA28311	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (453 aa)
	DpseGA23433	Uncharacterized protein. (1000 aa)
	DpseGA26658	PAP-associated domain-containing protein. (1310 aa)
	DpseGA27548	Suf domain-containing protein. (755 aa)
	DpseGA23632	Uncharacterized protein, isoform C. (308 aa)
	DpseGA17613	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (232 aa)
	DpseGA31582	Uncharacterized protein, isoform B. (92 aa)
	DpseGA27853	HTH La-type RNA-binding domain-containing protein. (92 aa)
	DpseGA31470	HTH La-type RNA-binding domain-containing protein. (148 aa)
	DpseGA27846	Uncharacterized protein, isoform B. (92 aa)
	A0A0R3NUT8	Pre-mRNA cleavage complex 2 protein Pcf11. (2003 aa)
	A0A0R3NTF2	DNA-directed RNA polymerase III subunit RPC11. (108 aa)
	DpseGA13540	Uncharacterized protein, isoform B. (882 aa)
	A0A0R3NPH6	Uncharacterized protein, isoform F. (382 aa)
	Q29AB0	Histone RNA hairpin-binding protein. (269 aa)
	Q29A65	Cytoplasmic polyadenylation element-binding protein. (902 aa)
	Q299S8	Non-canonical poly(A) RNA polymerase PAPD5/7. (400 aa)
	Q299P5	RRNA 2'-O-methyltransferase fibrillarin. (309 aa)
	Q299N6	Cleavage and polyadenylation specificity factor subunit 3. (684 aa)
	Q299N5	Cleavage stimulation factor subunit 2. (418 aa)
	Q297R7	Cleavage stimulation factor subunit 1. (424 aa)
	Q297P5	Uncharacterized protein, isoform C. (1012 aa)
	Q297M4	Polyadenylation factor subunit 2. (812 aa)
	Q297L5	TRNA nucleotidyltransferase (CCA-adding enzyme). (484 aa)
	Q297L3	Uncharacterized protein. (1170 aa)
	asun	Protein asunder; Plays a role as a regulator of spermatogenesis. Crucial regulator of the mitotic cell cycle and development. Required for the correct dynein-dynactin perinuclear localization important for nucleus- centrosome coupling that occur upon meiotic progression of primary spermatocytes. Crucial regulator of the mitotic cell cycle and development. Plays a role in sperm motility and fertility. May have a role in the PNG/PLU/GNU pathway (By similarity). (674 aa)
	Q295J3	U6 snRNA phosphodiesterase. (255 aa)
	Q294I1	Uncharacterized protein. (540 aa)
	Q293K9	Uncharacterized protein. (541 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NPH6	Q29AB0	A0A0R3NPH6	Q29AB0	Uncharacterized protein, isoform F.	Histone RNA hairpin-binding protein.	0.600
A0A0R3NTF2	A0A0R3NUT8	A0A0R3NTF2	A0A0R3NUT8	DNA-directed RNA polymerase III subunit RPC11.	Pre-mRNA cleavage complex 2 protein Pcf11.	0.467
A0A0R3NTF2	B5DYN4	A0A0R3NTF2	B5DYN4	DNA-directed RNA polymerase III subunit RPC11.	Integrator complex subunit 7.	0.430
A0A0R3NTF2	B5E0E7	A0A0R3NTF2	B5E0E7	DNA-directed RNA polymerase III subunit RPC11.	Uncharacterized protein.	0.599
A0A0R3NTF2	CycC	A0A0R3NTF2	Q29AI1	DNA-directed RNA polymerase III subunit RPC11.	Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase Cdk8 that phosphoryla [...]	0.491
A0A0R3NTF2	DpseGA11407	A0A0R3NTF2	Q29FM0	DNA-directed RNA polymerase III subunit RPC11.	Uncharacterized protein.	0.520
A0A0R3NTF2	DpseGA13540	A0A0R3NTF2	A0A0R3NSV3	DNA-directed RNA polymerase III subunit RPC11.	Uncharacterized protein, isoform B.	0.413
A0A0R3NTF2	DpseGA16124	A0A0R3NTF2	Q29FS2	DNA-directed RNA polymerase III subunit RPC11.	VWFA domain-containing protein.	0.409
A0A0R3NTF2	DpseGA21481	A0A0R3NTF2	Q2LYT9	DNA-directed RNA polymerase III subunit RPC11.	CID domain-containing protein.	0.413
A0A0R3NTF2	DpseGA23433	A0A0R3NTF2	B5DQ60	DNA-directed RNA polymerase III subunit RPC11.	Uncharacterized protein.	0.430
A0A0R3NTF2	DpseGA23999	A0A0R3NTF2	B5DT62	DNA-directed RNA polymerase III subunit RPC11.	INT_SG_DDX_CT_C domain-containing protein.	0.409
A0A0R3NTF2	DpseGA28311	A0A0R3NTF2	B5DRF0	DNA-directed RNA polymerase III subunit RPC11.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.590
A0A0R3NTF2	Q290A0	A0A0R3NTF2	Q290A0	DNA-directed RNA polymerase III subunit RPC11.	Integrator complex subunit 1.	0.510
A0A0R3NTF2	Q294I1	A0A0R3NTF2	Q294I1	DNA-directed RNA polymerase III subunit RPC11.	Uncharacterized protein.	0.599
A0A0R3NUT8	A0A0R3NTF2	A0A0R3NUT8	A0A0R3NTF2	Pre-mRNA cleavage complex 2 protein Pcf11.	DNA-directed RNA polymerase III subunit RPC11.	0.467
A0A0R3NUT8	B5DXG7	A0A0R3NUT8	B5DXG7	Pre-mRNA cleavage complex 2 protein Pcf11.	Pre-mRNA 3'-end-processing factor FIP1.	0.970
A0A0R3NUT8	B5DYG6	A0A0R3NUT8	B5DYG6	Pre-mRNA cleavage complex 2 protein Pcf11.	Cleavage and polyadenylation specificity factor subunit 2.	0.993
A0A0R3NUT8	DpseGA11407	A0A0R3NUT8	Q29FM0	Pre-mRNA cleavage complex 2 protein Pcf11.	Uncharacterized protein.	0.681
A0A0R3NUT8	DpseGA13540	A0A0R3NUT8	A0A0R3NSV3	Pre-mRNA cleavage complex 2 protein Pcf11.	Uncharacterized protein, isoform B.	0.812
A0A0R3NUT8	DpseGA16124	A0A0R3NUT8	Q29FS2	Pre-mRNA cleavage complex 2 protein Pcf11.	VWFA domain-containing protein.	0.609