(83 nodes) Positive regulation of kinase activity network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DpseGA14719	Uncharacterized protein, isoform A. (324 aa)
	Pgam5	Serine/threonine-protein phosphatase Pgam5, mitochondrial; Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity (By similarity). (289 aa)
	Cdc42	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity). (191 aa)
	DpseGA14783	Uncharacterized protein. (2527 aa)
	DpseGA32601	Fibrinogen C-terminal domain-containing protein. (186 aa)
	DpseGA30812	Protein kinase domain-containing protein. (120 aa)
	DpseGA31255	N-acetyltransferase domain-containing protein. (274 aa)
	DpseGA32390	Raptor_N domain-containing protein. (1683 aa)
	DpseGA30758	Uncharacterized protein, isoform A. (336 aa)
	DpseGA31462	Uncharacterized protein. (1072 aa)
	DpseGA16635	Uncharacterized protein. (3580 aa)
	DpseGA28399	Uncharacterized protein, isoform D. (915 aa)
	DpseGA25305	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (75 aa)
	DpseGA25435	Fibrinogen C-terminal domain-containing protein. (408 aa)
	DpseGA25820	Uncharacterized protein. (424 aa)
	DpseGA25946	Uncharacterized protein. (715 aa)
	DpseGA28018	Uncharacterized protein, isoform B. (1118 aa)
	DpseGA28100	Fibrinogen C-terminal domain-containing protein. (93 aa)
	DpseGA22885	SMAP domain-containing protein. (451 aa)
	DpseGA23874	Uncharacterized protein. (236 aa)
	DpseGA23864	Uncharacterized protein. (1212 aa)
	DpseGA23951	Uncharacterized protein. (1074 aa)
	DpseGA22544	Uncharacterized protein. (301 aa)
	DpseGA22537	INCENP_ARK-bind domain-containing protein. (184 aa)
	DpseGA25500	INCENP_ARK-bind domain-containing protein. (168 aa)
	B5DX82	Uncharacterized protein, isoform B. (800 aa)
	B5DYN3	Uncharacterized protein. (221 aa)
	B5DYR5	Insulin-like growth factor 1 receptor. (2293 aa)
	B5DZ84	Uncharacterized protein, isoform A. (205 aa)
	B5DZT4	Apoptosis-stimulating of p53 protein 1. (1081 aa)
	B5E1I1	Uncharacterized protein. (744 aa)
	B5E1I2	Uncharacterized protein. (740 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	Q296F4	Kinase suppressor of Ras 2. (1012 aa)
	Q296V8	Uncharacterized protein, isoform A. (286 aa)
	Q297M2	RB1-inducible coiled-coil protein 1. (1369 aa)
	Q297P6	Serine/threonine-protein kinase 11. (553 aa)
	Q298R4	Autophagy-related protein 13. (551 aa)
	DpseGA24053	Uncharacterized protein. (210 aa)
	Q29AC0	Beclin 1-associated autophagy-related key regulator. (496 aa)
	Q29AY5	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta. (1112 aa)
	DpseGA10691	Uncharacterized protein, isoform F. (1159 aa)
	DpseGA32895	Uncharacterized protein. (69 aa)
	DpseGA25491	Uncharacterized protein, isoform C. (493 aa)
	DpseGA20908	Receptor protein-tyrosine kinase. (1649 aa)
	A0A0R3NSL1	Uncharacterized protein, isoform A. (1036 aa)
	A0A0R3NS54	Tyrosine-protein kinase receptor torso. (939 aa)
	DpseGA11107	Uncharacterized protein, isoform B. (748 aa)
	A0A0R3NQF2	Uncharacterized protein, isoform B. (389 aa)
	A0A0R3NM99	Uncharacterized protein, isoform D. (649 aa)
	A0A0R3NH46	Uncharacterized protein, isoform A. (478 aa)
	Q29B16	Vacuole morphology and inheritance protein 14. (685 aa)
	Q294K5	Cyclin-dependent kinase regulatory subunit CKS1. (91 aa)
	Q293W0	Uncharacterized protein, isoform A. (800 aa)
	Q292H0	Muscle, skeletal, receptor tyrosine kinase. (739 aa)
	Sin1	Stress-activated map kinase-interacting protein 1; Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. (578 aa)
	Q28ZW1	Uncharacterized protein. (574 aa)
	Q28XM9	Uncharacterized protein, isoform A. (1439 aa)
	Q28XJ6	CDK-activating kinase assembly factor MAT1. (320 aa)
	Q28WV5	Serine/threonine-protein phosphatase PGAM5. (267 aa)
	Q28WN9	Uncharacterized protein, isoform C. (1744 aa)
	DpseGA13114	Uncharacterized protein. (305 aa)
	Q29C79	Uncharacterized protein, isoform A. (762 aa)
	DpseGA18843	Uncharacterized protein. (132 aa)
	DpseGA17944	Uncharacterized protein. (339 aa)
	DpseGA20413	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1212 aa)
	DpseGA15321	Uncharacterized protein. (192 aa)
	DpseGA20757	Uncharacterized protein. (1964 aa)
	DpseGA18776	SAM domain-containing protein. (201 aa)
	DpseGA19492	Uncharacterized protein; Belongs to the cyclin family. (1137 aa)
	DpseGA11342	Uncharacterized protein. (390 aa)
	bora	Protein aurora borealis; Required for the activation of Aurora-A (aur) at the onset of mitosis; Belongs to the BORA family. (544 aa)
	DpseGA12952	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1248 aa)
	DpseGA17947	Uncharacterized protein; Belongs to the eukaryotic ribosomal protein P1/P2 family. (112 aa)
	DpseGA17123	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily. Tyr protein kinase family. (813 aa)
	DpseGA19150	DBF4-type domain-containing protein. (1796 aa)
	DpseGA13366	Uncharacterized protein, isoform A; Belongs to the cyclin family. (395 aa)
	DpseGA19133	Uncharacterized protein, isoform B. (1364 aa)
	DpseGA14553	Uncharacterized protein. (585 aa)
	DpseGA14473	Uncharacterized protein. (623 aa)
	DpseGA18220	Small ubiquitin-related modifier. (90 aa)
	DpseGA13578	Uncharacterized protein; Belongs to the cyclin family. (423 aa)
	DpseGA16357	F5/8 type C domain-containing protein. (989 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NH46	B5DZ84	A0A0R3NH46	B5DZ84	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.504
A0A0R3NH46	Cdc42	A0A0R3NH46	Q29HY3	Uncharacterized protein, isoform A.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	0.605
A0A0R3NH46	DpseGA15321	A0A0R3NH46	Q29EV6	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.605
A0A0R3NH46	DpseGA20908	A0A0R3NH46	A0A0R3NSX3	Uncharacterized protein, isoform A.	Receptor protein-tyrosine kinase.	0.433
A0A0R3NH46	DpseGA22544	A0A0R3NH46	B5DS48	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.543
A0A0R3NM99	DpseGA14473	A0A0R3NM99	Q29K34	Uncharacterized protein, isoform D.	Uncharacterized protein.	0.924
A0A0R3NM99	DpseGA14553	A0A0R3NM99	Q29K37	Uncharacterized protein, isoform D.	Uncharacterized protein.	0.917
A0A0R3NQF2	Q29B16	A0A0R3NQF2	Q29B16	Uncharacterized protein, isoform B.	Vacuole morphology and inheritance protein 14.	0.944
A0A0R3NS54	Q29AY5	A0A0R3NS54	Q29AY5	Tyrosine-protein kinase receptor torso.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.	0.506
A0A0R3NS54	Ras85D	A0A0R3NS54	Q295X7	Tyrosine-protein kinase receptor torso.	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.	0.401
A0A0R3NSL1	B5DZ84	A0A0R3NSL1	B5DZ84	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.463
B5DX82	Q29AY5	B5DX82	Q29AY5	Uncharacterized protein, isoform B.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.	0.506
B5DX82	Ras85D	B5DX82	Q295X7	Uncharacterized protein, isoform B.	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.	0.407
B5DYN3	DpseGA17944	B5DYN3	Q29D51	Uncharacterized protein.	Uncharacterized protein.	0.432
B5DYR5	DpseGA20757	B5DYR5	Q29GP0	Insulin-like growth factor 1 receptor.	Uncharacterized protein.	0.422
B5DYR5	DpseGA28399	B5DYR5	A0A0R3P909	Insulin-like growth factor 1 receptor.	Uncharacterized protein, isoform D.	0.497
B5DYR5	DpseGA31462	B5DYR5	A0A0R3P3T6	Insulin-like growth factor 1 receptor.	Uncharacterized protein.	0.913
B5DYR5	DpseGA32390	B5DYR5	A0A0R3P030	Insulin-like growth factor 1 receptor.	Raptor_N domain-containing protein.	0.412
B5DYR5	Q28XM9	B5DYR5	Q28XM9	Insulin-like growth factor 1 receptor.	Uncharacterized protein, isoform A.	0.941
B5DYR5	Q29AY5	B5DYR5	Q29AY5	Insulin-like growth factor 1 receptor.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.	0.958