(63 nodes) Eye-antennal disc development network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Q28WK8	Uncharacterized protein. (498 aa)
	N6W6F6	Uncharacterized protein, isoform D. (867 aa)
	DpseGA22220	Uncharacterized protein, isoform E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1887 aa)
	B5E068	Uncharacterized protein, isoform A. (1785 aa)
	B5DXM0	T-cell leukemia homeobox protein 3. (348 aa)
	B5DWT5	Uncharacterized protein. (1390 aa)
	DpseGA28721	MNNL domain-containing protein. (102 aa)
	DpseGA23169	HTH psq-type domain-containing protein. (515 aa)
	DpseGA27636	Uncharacterized protein, isoform A. (546 aa)
	DpseGA28271	Uncharacterized protein, isoform A. (1141 aa)
	DpseGA28528	Uncharacterized protein. (2709 aa)
	DpseGA28280	Homeobox domain-containing protein. (658 aa)
	DpseGA22609	Uncharacterized protein, isoform A. (868 aa)
	DpseGA25690	Uncharacterized protein, isoform A. (1469 aa)
	DpseGA16635	Uncharacterized protein. (3580 aa)
	DpseGA25945	Uncharacterized protein, isoform B. (546 aa)
	DpseGA23680	Uncharacterized protein, isoform C. (439 aa)
	A0A0R3NT42	Cell division cycle 20-like protein 1, cofactor of APC complex. (459 aa)
	A0A0R3NNK2	annotation not available (352 aa)
	A0A0R3NHH1	Signal transducer and activator of transcription 5B. (792 aa)
	A0A0R3NG95	Uncharacterized protein, isoform F. (729 aa)
	A0A0R3NG32	Uncharacterized protein. (1222 aa)
	DpseGA28287	Uncharacterized protein, isoform A. (626 aa)
	DpseGA18550	Ski_Sno domain-containing protein. (1032 aa)
	DpseGA10346	Uncharacterized protein. (647 aa)
	trc	Serine/threonine-protein kinase tricorner; Has an important role, with fry, in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites. Affects cellular morphogenesis by regulating the expression of target genes that encode cytoskeleton-interacting proteins and not via the direct modification of the cytoskeleton. Maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons (By similarity). Belongs to the pro [...] (458 aa)
	DpseGA16889	Uncharacterized protein. (259 aa)
	DpseGA18676	Uncharacterized protein. (405 aa)
	DpseGA12497	Uncharacterized protein. (995 aa)
	DpseGA21875	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (683 aa)
	ck	Myosin-VIIa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements: can function in cells as a single-molecule cargo transporter. A very slow and high- duty-ratio motor, may be suitable for tension maintenance of actin filaments. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Plays a key role in the formation of cellular projections and other actin-based functions required for embryonic and larval viability. Necessary for auditory transduction [...] (2168 aa)
	DpseGA18219	C2H2-type domain-containing protein. (537 aa)
	DpseGA18043	C2H2-type domain-containing protein. (573 aa)
	smo	Smo; Belongs to the G-protein coupled receptor Fz/Smo family. (1061 aa)
	DpseGA21636	Uncharacterized protein, isoform A. (775 aa)
	chinmo	Chinmo. (854 aa)
	DpseGA17785	Uncharacterized protein, isoform A. (395 aa)
	DpseGA18499	Uncharacterized protein. (1330 aa)
	DpseGA13532	Uncharacterized protein, isoform A. (762 aa)
	DpseGA17189	Uncharacterized protein. (524 aa)
	DpseGA18871	Uncharacterized protein, isoform A. (1850 aa)
	DpseGA14036	Uncharacterized protein. (1178 aa)
	DpseGA20940	SKIP_SNW domain-containing protein. (547 aa)
	DpseGA22115	C2H2-type domain-containing protein. (565 aa)
	DpseGA15568	Uncharacterized protein, isoform A. (478 aa)
	DpseGA19283	Uncharacterized protein. (539 aa)
	DpseGA21570	Uncharacterized protein. (704 aa)
	DpseGA18236	Uncharacterized protein. (479 aa)
	dan	Protein distal antenna; Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to c [...] (683 aa)
	danr	Protein distal antenna-related; Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) ge [...] (432 aa)
	ey	Ey, isoform A. (896 aa)
	Q29C79	Uncharacterized protein, isoform A. (762 aa)
	Dpse_ato	Atonal protein 1/7. (330 aa)
	Q297H8	Mothers against decapentaplegic homolog 6. (584 aa)
	Q295Z2	Zinc finger protein ZIC, invertebrate. (645 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	Q295V9	Uncharacterized protein, isoform G. (1049 aa)
	Q293P0	Uncharacterized protein. (852 aa)
	Q290N3	Uncharacterized protein. (335 aa)
	Q28YV2	Uncharacterized protein, isoform B. (706 aa)
	Q28Y68	Uncharacterized protein. (1299 aa)
	Q28Y28	Uncharacterized protein. (1671 aa)
	Q28XM9	Uncharacterized protein, isoform A. (1439 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NG32	B5DWT5	A0A0R3NG32	B5DWT5	Uncharacterized protein.	Uncharacterized protein.	0.900
A0A0R3NG32	DpseGA28528	A0A0R3NG32	B5DM97	Uncharacterized protein.	Uncharacterized protein.	0.979
A0A0R3NG32	DpseGA28721	A0A0R3NG32	B5DUT0	Uncharacterized protein.	MNNL domain-containing protein.	0.430
A0A0R3NG32	Q293P0	A0A0R3NG32	Q293P0	Uncharacterized protein.	Uncharacterized protein.	0.618
A0A0R3NG95	DpseGA22609	A0A0R3NG95	B5DLK1	Uncharacterized protein, isoform F.	Uncharacterized protein, isoform A.	0.751
A0A0R3NG95	Q28WK8	A0A0R3NG95	Q28WK8	Uncharacterized protein, isoform F.	Uncharacterized protein.	0.813
A0A0R3NG95	Ras85D	A0A0R3NG95	Q295X7	Uncharacterized protein, isoform F.	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.	0.430
A0A0R3NHH1	DpseGA14036	A0A0R3NHH1	Q29H22	Signal transducer and activator of transcription 5B.	Uncharacterized protein.	0.982
A0A0R3NHH1	DpseGA19283	A0A0R3NHH1	Q29G27	Signal transducer and activator of transcription 5B.	Uncharacterized protein.	0.722
A0A0R3NHH1	Q28XM9	A0A0R3NHH1	Q28XM9	Signal transducer and activator of transcription 5B.	Uncharacterized protein, isoform A.	0.877
A0A0R3NHH1	chinmo	A0A0R3NHH1	Q29NN0	Signal transducer and activator of transcription 5B.	Chinmo.	0.439
A0A0R3NNK2	DpseGA28528	A0A0R3NNK2	B5DM97	annotation not available	Uncharacterized protein.	0.495
A0A0R3NT42	DpseGA15568	A0A0R3NT42	Q29G84	Cell division cycle 20-like protein 1, cofactor of APC complex.	Uncharacterized protein, isoform A.	0.902
B5DWT5	A0A0R3NG32	B5DWT5	A0A0R3NG32	Uncharacterized protein.	Uncharacterized protein.	0.900
B5DWT5	DpseGA28528	B5DWT5	B5DM97	Uncharacterized protein.	Uncharacterized protein.	0.979
B5DWT5	Q293P0	B5DWT5	Q293P0	Uncharacterized protein.	Uncharacterized protein.	0.618
B5DXM0	DpseGA17785	B5DXM0	Q29N35	T-cell leukemia homeobox protein 3.	Uncharacterized protein, isoform A.	0.879
DpseGA10346	DpseGA21875	Q2M0M9	Q29PD1	Uncharacterized protein.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.405
DpseGA12497	DpseGA21875	Q29PF3	Q29PD1	Uncharacterized protein.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.457
DpseGA14036	A0A0R3NHH1	Q29H22	A0A0R3NHH1	Uncharacterized protein.	Signal transducer and activator of transcription 5B.	0.982