(47 nodes) Negative regulation of hippo signaling network (Drosophila pseudoobscura)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Q294V1	RAC serine/threonine-protein kinase. (530 aa)
	DpseGA27838	Uncharacterized protein, isoform A. (1448 aa)
	B5DX68	F-box and WD-40 domain protein 1/11. (590 aa)
	B5DYA7	Ras association domain-containing protein 2/4. (822 aa)
	B5DZC0	Uncharacterized protein. (371 aa)
	B5DZE2	Uncharacterized protein, isoform K. (3989 aa)
	I5APZ2	Uncharacterized protein. (214 aa)
	Q28YB0	Uncharacterized protein. (774 aa)
	Q28Z37	E3 ubiquitin ligase SMURF1/2. (1096 aa)
	Q291A6	E3 ubiquitin-protein ligase SH3RF. (858 aa)
	Q292F7	SH3 and multiple ankyrin repeat domains protein. (1946 aa)
	Q292Z2	Uncharacterized protein. (223 aa)
	DpseGA22282	Uncharacterized protein. (194 aa)
	DpseGA22536	Uncharacterized protein. (692 aa)
	DpseGA29082	Uncharacterized protein, isoform A. (967 aa)
	DpseGA26057	Uncharacterized protein, isoform A. (3586 aa)
	DpseGA25737	Serine/threonine-protein phosphatase. (309 aa)
	DpseGA25880	Uncharacterized protein, isoform A. (664 aa)
	DpseGA28417	Uncharacterized protein, isoform D. (1057 aa)
	DpseGA11051	Uncharacterized protein, isoform B. (929 aa)
	DpseGA33039	Uncharacterized protein. (54 aa)
	DpseGA20319	Uncharacterized protein, isoform E. (744 aa)
	DpseGA25301	Uncharacterized protein, isoform C; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1480 aa)
	DpseGA32581	Uncharacterized protein. (182 aa)
	A0A0R3NSV7	MAP/microtubule affinity-regulating kinase. (1192 aa)
	A0A0R3NS54	Tyrosine-protein kinase receptor torso. (939 aa)
	A0A0R3NRT2	Calmodulin-regulated spectrin-associated protein. (1815 aa)
	A0A0R3NQH0	Uncharacterized protein, isoform B. (1874 aa)
	A0A0R3NP93	annotation not available (982 aa)
	A0A0R3NLK6	Serine/threonine-protein kinase SIK3. (1494 aa)
	Q299W4	Mitogen-activated protein kinase kinase kinase 4. (1574 aa)
	Q29AF1	Uncharacterized protein. (199 aa)
	DpseGA16614	Uncharacterized protein. (274 aa)
	DpseGA13409	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1071 aa)
	DpseGA14321	Protein kinase domain-containing protein. (1356 aa)
	DpseGA20611	Protein kinase domain-containing protein. (915 aa)
	DpseGA13337	Uncharacterized protein, isoform A; Belongs to the peptidase C19 family. (1144 aa)
	DpseGA11504	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (338 aa)
	DpseGA15193	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily. (337 aa)
	DpseGA18086	Protein kinase domain-containing protein. (1481 aa)
	DpseGA13113	WD_REPEATS_REGION domain-containing protein. (343 aa)
	DpseGA10369	Uncharacterized protein. (1855 aa)
	DpseGA15150	Uncharacterized protein. (184 aa)
	DpseGA19649	Uncharacterized protein. (1976 aa)
	DpseGA10119	Uncharacterized protein. (325 aa)
	DpseGA20320	Mitogen-activated protein kinase. (365 aa)
	DpseGA18056	Uncharacterized protein, isoform A. (976 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NLK6	A0A0R3NP93	A0A0R3NLK6	A0A0R3NP93	Serine/threonine-protein kinase SIK3.	annotation not available	0.428
A0A0R3NP93	A0A0R3NLK6	A0A0R3NP93	A0A0R3NLK6	annotation not available	Serine/threonine-protein kinase SIK3.	0.428
A0A0R3NP93	A0A0R3NSV7	A0A0R3NP93	A0A0R3NSV7	annotation not available	MAP/microtubule affinity-regulating kinase.	0.593
A0A0R3NP93	DpseGA15150	A0A0R3NP93	Q2M061	annotation not available	Uncharacterized protein.	0.443
A0A0R3NP93	DpseGA18056	A0A0R3NP93	Q29LM8	annotation not available	Uncharacterized protein, isoform A.	0.460
A0A0R3NP93	DpseGA18086	A0A0R3NP93	Q29J88	annotation not available	Protein kinase domain-containing protein.	0.406
A0A0R3NP93	DpseGA19649	A0A0R3NP93	Q29M21	annotation not available	Uncharacterized protein.	0.803
A0A0R3NP93	DpseGA20320	A0A0R3NP93	Q29K65	annotation not available	Mitogen-activated protein kinase.	0.555
A0A0R3NP93	Q28Z37	A0A0R3NP93	Q28Z37	annotation not available	E3 ubiquitin ligase SMURF1/2.	0.774
A0A0R3NP93	Q292F7	A0A0R3NP93	Q292F7	annotation not available	SH3 and multiple ankyrin repeat domains protein.	0.541
A0A0R3NQH0	DpseGA10369	A0A0R3NQH0	Q2M0M0	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.481
A0A0R3NQH0	DpseGA19649	A0A0R3NQH0	Q29M21	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.485
A0A0R3NSV7	A0A0R3NP93	A0A0R3NSV7	A0A0R3NP93	MAP/microtubule affinity-regulating kinase.	annotation not available	0.593
A0A0R3NSV7	DpseGA25737	A0A0R3NSV7	B5DIG8	MAP/microtubule affinity-regulating kinase.	Serine/threonine-protein phosphatase.	0.439
A0A0R3NSV7	DpseGA25880	A0A0R3NSV7	B5DHZ5	MAP/microtubule affinity-regulating kinase.	Uncharacterized protein, isoform A.	0.444
B5DX68	DpseGA15193	B5DX68	Q29J63	F-box and WD-40 domain protein 1/11.	Uncharacterized protein, isoform A; Belongs to the protein kinase superfamily.	0.505
B5DX68	DpseGA25737	B5DX68	B5DIG8	F-box and WD-40 domain protein 1/11.	Serine/threonine-protein phosphatase.	0.427
B5DX68	DpseGA25880	B5DX68	B5DHZ5	F-box and WD-40 domain protein 1/11.	Uncharacterized protein, isoform A.	0.617
B5DX68	DpseGA27838	B5DX68	B5DS65	F-box and WD-40 domain protein 1/11.	Uncharacterized protein, isoform A.	0.910
B5DX68	Q28YB0	B5DX68	Q28YB0	F-box and WD-40 domain protein 1/11.	Uncharacterized protein.	0.994