(41 nodes) ERAD pathway network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Q28Y84	Uncharacterized protein. (320 aa)
	Q28XH1	Uncharacterized protein, isoform A. (704 aa)
	B5DY45	Uncharacterized protein. (258 aa)
	B5DXZ2	Uncharacterized protein, isoform A. (665 aa)
	B5DWN4	Uncharacterized protein. (405 aa)
	DpseGA17701	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (972 aa)
	DpseGA17461	AAA domain-containing protein; Belongs to the AAA ATPase family. (397 aa)
	DpseGA17988	Uncharacterized protein, isoform A; Belongs to the heat shock protein 70 family. (656 aa)
	DpseGA13966	RING-type domain-containing protein. (321 aa)
	DpseGA28600	RING-type domain-containing protein. (229 aa)
	DpseGA27708	J domain-containing protein. (237 aa)
	DpseGA22629	RING-type domain-containing protein. (217 aa)
	DpseGA28922	Uncharacterized protein, isoform A. (148 aa)
	DpseGA25325	Uncharacterized protein, isoform A. (132 aa)
	DpseGA10741	Uncharacterized protein, isoform B. (996 aa)
	A0A0R3NMF6	DnaJ homolog subfamily B member 12. (380 aa)
	A0A0R3NLA7	E3 ubiquitin-protein ligase RNF139. (806 aa)
	DpseGA20429	Uncharacterized protein, isoform B. (1294 aa)
	DpseGA20215	AAA domain-containing protein; Belongs to the AAA ATPase family. (407 aa)
	DpseGA19904	Uncharacterized protein. (1546 aa)
	DpseGA19461	Uncharacterized protein. (313 aa)
	DpseGA12095	RING-CH-type domain-containing protein. (1048 aa)
	DpseGA19848	Uncharacterized protein. (529 aa)
	DpseGA10631	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (243 aa)
	DpseGA10282	Uncharacterized protein, isoform A. (462 aa)
	DpseGA18656	TPR_REGION domain-containing protein. (354 aa)
	DpseGA22136	U-box domain-containing protein. (1209 aa)
	DpseGA19052	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (804 aa)
	DpseGA14623	RING-CH-type domain-containing protein. (265 aa)
	DpseGA18185	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (167 aa)
	GA18292	Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. (358 aa)
	DpseGA20784	UBX domain-containing protein. (676 aa)
	Q29AG0	Heat shock protein 90kDa beta. (792 aa)
	Q29A89	Ubiquitin-conjugating enzyme E2 J2. (282 aa)
	Q29A36	Endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase. (681 aa)
	Q299C9	Uncharacterized protein, isoform A. (811 aa)
	Q298R1	E3 ubiquitin-protein ligase synoviolin. (662 aa)
	Q298R0	Uncharacterized protein. (328 aa)
	Q292W7	DnaJ homolog subfamily B member 12. (385 aa)
	Q292C8	Proteasome component ECM29. (1894 aa)
	Q290N9	Uncharacterized protein, isoform A. (196 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NLA7	B5DY45	A0A0R3NLA7	B5DY45	E3 ubiquitin-protein ligase RNF139.	Uncharacterized protein.	0.850
A0A0R3NLA7	DpseGA10282	A0A0R3NLA7	Q29LE0	E3 ubiquitin-protein ligase RNF139.	Uncharacterized protein, isoform A.	0.682
A0A0R3NLA7	DpseGA10631	A0A0R3NLA7	Q29LN8	E3 ubiquitin-protein ligase RNF139.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.820
A0A0R3NLA7	DpseGA12095	A0A0R3NLA7	Q2LYS5	E3 ubiquitin-protein ligase RNF139.	RING-CH-type domain-containing protein.	0.676
A0A0R3NLA7	DpseGA14623	A0A0R3NLA7	Q29J57	E3 ubiquitin-protein ligase RNF139.	RING-CH-type domain-containing protein.	0.547
A0A0R3NLA7	DpseGA17701	A0A0R3NLA7	Q29I32	E3 ubiquitin-protein ligase RNF139.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.403
A0A0R3NLA7	DpseGA17988	A0A0R3NLA7	Q29HE5	E3 ubiquitin-protein ligase RNF139.	Uncharacterized protein, isoform A; Belongs to the heat shock protein 70 family.	0.440
A0A0R3NLA7	DpseGA18185	A0A0R3NLA7	Q29I41	E3 ubiquitin-protein ligase RNF139.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.806
A0A0R3NLA7	DpseGA19461	A0A0R3NLA7	Q2LZ30	E3 ubiquitin-protein ligase RNF139.	Uncharacterized protein.	0.519
A0A0R3NLA7	DpseGA19848	A0A0R3NLA7	Q29NJ4	E3 ubiquitin-protein ligase RNF139.	Uncharacterized protein.	0.914
A0A0R3NLA7	Q28XH1	A0A0R3NLA7	Q28XH1	E3 ubiquitin-protein ligase RNF139.	Uncharacterized protein, isoform A.	0.661
A0A0R3NLA7	Q28Y84	A0A0R3NLA7	Q28Y84	E3 ubiquitin-protein ligase RNF139.	Uncharacterized protein.	0.527
A0A0R3NLA7	Q299C9	A0A0R3NLA7	Q299C9	E3 ubiquitin-protein ligase RNF139.	Uncharacterized protein, isoform A.	0.812
A0A0R3NMF6	DpseGA17988	A0A0R3NMF6	Q29HE5	DnaJ homolog subfamily B member 12.	Uncharacterized protein, isoform A; Belongs to the heat shock protein 70 family.	0.688
A0A0R3NMF6	Q29AG0	A0A0R3NMF6	Q29AG0	DnaJ homolog subfamily B member 12.	Heat shock protein 90kDa beta.	0.499
B5DWN4	B5DXZ2	B5DWN4	B5DXZ2	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.975
B5DWN4	DpseGA17701	B5DWN4	Q29I32	Uncharacterized protein.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.599
B5DWN4	DpseGA17988	B5DWN4	Q29HE5	Uncharacterized protein.	Uncharacterized protein, isoform A; Belongs to the heat shock protein 70 family.	0.975
B5DWN4	DpseGA19848	B5DWN4	Q29NJ4	Uncharacterized protein.	Uncharacterized protein.	0.502
B5DWN4	DpseGA19904	B5DWN4	Q2M0E2	Uncharacterized protein.	Uncharacterized protein.	0.695