(45 nodes) Mitotic cell cycle phase transition network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DpseGA19247	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (508 aa)
	DpseGA21606	Uncharacterized protein. (2023 aa)
	DpseGA11484	Serine/threonine-protein phosphatase. (303 aa)
	DpseGA28605	Cyclin_C domain-containing protein; Belongs to the cyclin family. (457 aa)
	DpseGA28604	Cyclin_C domain-containing protein; Belongs to the cyclin family. (479 aa)
	DpseGA10566	Uncharacterized protein. (416 aa)
	DpseGA17788	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (632 aa)
	DpseGA28992	TPR_REGION domain-containing protein. (681 aa)
	DpseGA27869	Uncharacterized protein, isoform A; Belongs to the cyclin family. (289 aa)
	DpseGA25959	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (349 aa)
	DpseGA22864	Uncharacterized protein. (604 aa)
	GA22810	Ubiquitin-conjugating enzyme E2 S; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. (209 aa)
	DpseGA26523	Uncharacterized protein. (823 aa)
	DpseGA28311	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (453 aa)
	DpseGA25706	Uncharacterized protein; Belongs to the cyclin family. (434 aa)
	B5E095	Kinesin family member 20. (620 aa)
	Q28WU9	Uncharacterized protein, isoform H. (1649 aa)
	Q290C0	Anaphase-promoting complex subunit 2. (802 aa)
	Q290U3	Cyclin-dependent kinase 5. (294 aa)
	Q291N4	Uncharacterized protein, isoform C. (542 aa)
	Q295K4	Uncharacterized protein, isoform A. (835 aa)
	Q296G6	Ras homolog enriched in brain. (182 aa)
	Q29A66	Anaphase-promoting complex subunit 6. (718 aa)
	DpseGA10512	E2F_TDP domain-containing protein. (374 aa)
	DpseGA18558	Uncharacterized protein, isoform A. (430 aa)
	DpseGA12613	JmjC domain-containing protein. (398 aa)
	DpseGA16888	Uncharacterized protein, isoform A. (572 aa)
	DpseGA20138	Uncharacterized protein, isoform A. (463 aa)
	DpseGA21205	TPR_REGION domain-containing protein. (932 aa)
	Q29AX7	Uncharacterized protein, isoform C. (314 aa)
	Q29AJ7	Serine/threonine-protein phosphatase 2A regulatory subunit B. (511 aa)
	Q29AE9	Uncharacterized protein, isoform E. (566 aa)
	DpseGA10491	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (176 aa)
	DpseGA13710	Uncharacterized protein, isoform B. (517 aa)
	A0A0R3NHI5	Uncharacterized protein, isoform A. (2503 aa)
	DpseGA24058	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (218 aa)
	DpseGA25615	Uncharacterized protein. (192 aa)
	DpseGA27863	Cyclin_C domain-containing protein; Belongs to the cyclin family. (355 aa)
	B5DY97	G2/mitotic-specific cyclin-B2. (356 aa)
	Q29BF0	Uncharacterized protein. (746 aa)
	Q29BX3	M-phase inducer phosphatase. (497 aa)
	Q29CB7	Serine/threonine-protein kinase LATS1/2. (1143 aa)
	Q29CG1	G2/mitotic-specific cyclin-B3. (576 aa)
	DpseGA21500	Cmyb_C domain-containing protein. (337 aa)
	DpseGA10409	Protein kinase domain-containing protein. (609 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B5DY97	DpseGA10409	B5DY97	Q29DP5	G2/mitotic-specific cyclin-B2.	Protein kinase domain-containing protein.	0.796
B5DY97	DpseGA10491	B5DY97	Q2M0M1	G2/mitotic-specific cyclin-B2.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.703
B5DY97	DpseGA16888	B5DY97	Q2LZB3	G2/mitotic-specific cyclin-B2.	Uncharacterized protein, isoform A.	0.785
B5DY97	DpseGA17788	B5DY97	Q29KE8	G2/mitotic-specific cyclin-B2.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.717
B5DY97	DpseGA18558	B5DY97	Q29P41	G2/mitotic-specific cyclin-B2.	Uncharacterized protein, isoform A.	0.665
B5DY97	DpseGA19247	B5DY97	Q29DY8	G2/mitotic-specific cyclin-B2.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.839
B5DY97	DpseGA21205	B5DY97	Q2M0G0	G2/mitotic-specific cyclin-B2.	TPR_REGION domain-containing protein.	0.804
B5DY97	DpseGA21606	B5DY97	Q29G49	G2/mitotic-specific cyclin-B2.	Uncharacterized protein.	0.480
B5DY97	DpseGA22864	B5DY97	B5DKG2	G2/mitotic-specific cyclin-B2.	Uncharacterized protein.	0.453
B5DY97	DpseGA24058	B5DY97	B5DU31	G2/mitotic-specific cyclin-B2.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.908
B5DY97	DpseGA25706	B5DY97	B5DIL4	G2/mitotic-specific cyclin-B2.	Uncharacterized protein; Belongs to the cyclin family.	0.425
B5DY97	DpseGA27863	B5DY97	B5DUW2	G2/mitotic-specific cyclin-B2.	Cyclin_C domain-containing protein; Belongs to the cyclin family.	0.535
B5DY97	DpseGA28604	B5DY97	B5DRS7	G2/mitotic-specific cyclin-B2.	Cyclin_C domain-containing protein; Belongs to the cyclin family.	0.535
B5DY97	DpseGA28605	B5DY97	B5DRS8	G2/mitotic-specific cyclin-B2.	Cyclin_C domain-containing protein; Belongs to the cyclin family.	0.535
B5DY97	DpseGA28992	B5DY97	Q29KS5	G2/mitotic-specific cyclin-B2.	TPR_REGION domain-containing protein.	0.628
B5DY97	GA22810	B5DY97	B5DKM4	G2/mitotic-specific cyclin-B2.	Ubiquitin-conjugating enzyme E2 S; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.	0.446
B5DY97	Q290C0	B5DY97	Q290C0	G2/mitotic-specific cyclin-B2.	Anaphase-promoting complex subunit 2.	0.514
B5DY97	Q29A66	B5DY97	Q29A66	G2/mitotic-specific cyclin-B2.	Anaphase-promoting complex subunit 6.	0.555
B5DY97	Q29AJ7	B5DY97	Q29AJ7	G2/mitotic-specific cyclin-B2.	Serine/threonine-protein phosphatase 2A regulatory subunit B.	0.613
B5DY97	Q29AX7	B5DY97	Q29AX7	G2/mitotic-specific cyclin-B2.	Uncharacterized protein, isoform C.	0.841