(32 nodes) Maintenance of protein location network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A0R3NU81	Uncharacterized protein, isoform B. (248 aa)
	DpseGA28200	Uncharacterized protein, isoform C. (165 aa)
	DpseGA25416	ER lumen protein-retaining receptor. (212 aa)
	DpseGA22759	Uncharacterized protein, isoform A; Belongs to the 14-3-3 family. (250 aa)
	DpseGA23728	Uncharacterized protein. (2422 aa)
	I7M5V8	Transmembrane anterior posterior transformation protein 1. (688 aa)
	Q28WZ2	Nuclear pore complex protein Nup214. (1709 aa)
	Q28XY8	Rac GTPase-activating protein 1. (624 aa)
	Q28YJ6	Vacuolar protein sorting-associated protein 13A/C. (3328 aa)
	Q290M8	Ankyrin repeat domain-containing protein 13. (573 aa)
	Q291Z7	Uncharacterized protein. (475 aa)
	cos	Kinesin-like protein costa; Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation. Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome- mediated processing to generate its repressor form. Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation (By similarity). (1223 aa)
	Q296L6	Uncharacterized protein. (207 aa)
	Q296W0	Uncharacterized protein, isoform A. (262 aa)
	Q299V1	Uncharacterized protein. (480 aa)
	SuUR	SuUR. (986 aa)
	DpseGA21874	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	DpseGA19176	ANK_REP_REGION domain-containing protein. (532 aa)
	DpseGA18717	ER lumen protein-retaining receptor. (212 aa)
	DpseGA14608	Uncharacterized protein, isoform A. (1097 aa)
	iHog	Interference hedgehog; Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc). Belongs to the immunoglobulin superfamily. IHOG family. (903 aa)
	DpseGA22026	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1388 aa)
	DpseGA21920	Uncharacterized protein, isoform A; Belongs to the integrin alpha chain family. (1368 aa)
	Cdc42	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity). (191 aa)
	DpseGA17886	Uncharacterized protein, isoform A. (376 aa)
	DpseGA15492	Uncharacterized protein. (730 aa)
	Q29AZ4	Nuclear pore complex protein Nup88. (701 aa)
	DpseGA20834	Uncharacterized protein, isoform C. (1380 aa)
	DpseGA11700	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (887 aa)
	DpseGA18565	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (527 aa)
	Q29C91	Vacuolar protein sorting-associated protein 13B. (3731 aa)
	DpseGA22276	Uncharacterized protein, isoform B. (1132 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NU81	DpseGA21920	A0A0R3NU81	Q29IK3	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A; Belongs to the integrin alpha chain family.	0.629
A0A0R3NU81	DpseGA22759	A0A0R3NU81	B5DKW8	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A; Belongs to the 14-3-3 family.	0.938
A0A0R3NU81	Q296W0	A0A0R3NU81	Q296W0	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform A.	0.937
Cdc42	DpseGA14608	Q29HY3	Q29LX2	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	Uncharacterized protein, isoform A.	0.796
Cdc42	DpseGA20834	Q29HY3	Q29EP3	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	Uncharacterized protein, isoform C.	0.672
Cdc42	DpseGA21874	Q29HY3	Q29PL9	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.505
Cdc42	DpseGA22026	Q29HY3	Q29IT7	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.737
Cdc42	Q28XY8	Q29HY3	Q28XY8	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	Rac GTPase-activating protein 1.	0.513
DpseGA11700	DpseGA14608	Q29D63	Q29LX2	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein, isoform A.	0.502
DpseGA11700	DpseGA20834	Q29D63	Q29EP3	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein, isoform C.	0.956
DpseGA11700	Q28XY8	Q29D63	Q28XY8	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Rac GTPase-activating protein 1.	0.994
DpseGA11700	cos	Q29D63	Q292S8	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein costa; Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation. Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome- mediated processing to generate its repressor form. Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation (By similarity).	0.484
DpseGA14608	Cdc42	Q29LX2	Q29HY3	Uncharacterized protein, isoform A.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	0.796
DpseGA14608	DpseGA11700	Q29LX2	Q29D63	Uncharacterized protein, isoform A.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.502
DpseGA14608	DpseGA17886	Q29LX2	Q29H46	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.444
DpseGA14608	DpseGA20834	Q29LX2	Q29EP3	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform C.	0.694
DpseGA14608	DpseGA21874	Q29LX2	Q29PL9	Uncharacterized protein, isoform A.	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.726
DpseGA14608	DpseGA22026	Q29LX2	Q29IT7	Uncharacterized protein, isoform A.	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.660
DpseGA17886	DpseGA14608	Q29H46	Q29LX2	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.444
DpseGA17886	DpseGA21874	Q29H46	Q29PL9	Uncharacterized protein, isoform A.	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.669