(66 nodes) Regulation of JNK cascade network (Drosophila pseudoobscura)

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Your Input:
	syd	JNK-interacting protein 3; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK-signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Syd is required for efficient kinesin-I mediated axonal transport (By similarity). (1235 aa)
	DpseGA10461	UBIQUITIN_CONJUGAT_2 domain-containing protein. (165 aa)
	DpseGA10222	Uncharacterized protein. (780 aa)
	DpseGA18985	Battenin. (437 aa)
	DpseGA18104	Uncharacterized protein. (72 aa)
	DpseGA10370	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (485 aa)
	DpseGA12519	Uncharacterized protein. (787 aa)
	DpseGA18811	ELMO domain-containing protein. (724 aa)
	DpseGA17928	Uncharacterized protein. (694 aa)
	DpseGA14356	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (276 aa)
	DpseGA11633	Uncharacterized protein. (853 aa)
	DpseGA12826	Uncharacterized protein. (380 aa)
	DpseGA11484	Serine/threonine-protein phosphatase. (303 aa)
	DpseGA11481	Uncharacterized protein. (1960 aa)
	Cdc42	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity). (191 aa)
	DpseGA10670	Uncharacterized protein. (464 aa)
	DpseGA15484	Uncharacterized protein. (201 aa)
	DpseGA14958	Protein kinase domain-containing protein. (683 aa)
	DpseGA20104	Uncharacterized protein, isoform A; Belongs to the PDGF/VEGF growth factor family. (323 aa)
	DpseGA15321	Uncharacterized protein. (192 aa)
	DpseGA11383	Ubiquitin carboxyl-terminal hydrolase. (829 aa)
	DpseGA21595	Uncharacterized protein, isoform A. (570 aa)
	DpseGA13993	Uncharacterized protein. (297 aa)
	Q29BV8	Uncharacterized protein, isoform E. (367 aa)
	Q29BG1	Programmed cell death 6-interacting protein. (841 aa)
	pont	RuvB-like helicase 1; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth (By similarity). (456 aa)
	Q29AF1	Uncharacterized protein. (199 aa)
	Q299W4	Mitogen-activated protein kinase kinase kinase 4. (1574 aa)
	Q298W3	Uncharacterized protein, isoform A. (906 aa)
	Q298R5	LIM and senescent cell antigen-like-containing domain protein 1/2. (348 aa)
	Q298N6	Histone arginine demethylase JMJD6. (434 aa)
	Q297P6	Serine/threonine-protein kinase 11. (553 aa)
	Q296F0	Eukaryotic translation initiation factor 2-alpha kinase 3. (1181 aa)
	Q296A4	Uncharacterized protein, isoform A. (2113 aa)
	Dpse_Pk92B	Mitogen-activated protein kinase kinase kinase 5. (1357 aa)
	Q294G8	Uncharacterized protein, isoform A. (1506 aa)
	Dpse_Atg9	Autophagy-related protein 9. (827 aa)
	Q291A6	E3 ubiquitin-protein ligase SH3RF. (858 aa)
	Q28X29	Capping protein (actin filament) muscle Z-line, alpha. (286 aa)
	N6W5Y1	annotation not available (1271 aa)
	I5APL5	Programmed cell death protein 6. (185 aa)
	I5ANT7	Dedicator of cytokinesis protein 1. (2003 aa)
	B5E0Z6	Uncharacterized protein. (122 aa)
	B5DW47	Ras-related protein Ral-A. (200 aa)
	DpseGA22236	Uncharacterized protein. (122 aa)
	Urm1	Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate [...] (99 aa)
	DpseGA22604	Uncharacterized protein, isoform A. (5496 aa)
	DpseGA22660	Uncharacterized protein, isoform H. (880 aa)
	DpseGA27711	USP domain-containing protein. (526 aa)
	DpseGA25391	Uncharacterized protein. (282 aa)
	DpseGA21564	Uncharacterized protein, isoform C. (666 aa)
	DpseGA18154	Uncharacterized protein, isoform B. (484 aa)
	DpseGA11322	Uncharacterized protein, isoform B. (496 aa)
	DpseGA11051	Uncharacterized protein, isoform B. (929 aa)
	DpseGA32911	Uncharacterized protein. (83 aa)
	DpseGA23680	Uncharacterized protein, isoform C. (439 aa)
	DpseGA15916	Uncharacterized protein, isoform B; Belongs to the protein kinase superfamily. (384 aa)
	DpseGA20319	Uncharacterized protein, isoform E. (744 aa)
	DpseGA10133	Uncharacterized protein, isoform B. (242 aa)
	DpseGA30839	Uncharacterized protein. (560 aa)
	DpseGA28774	Uncharacterized protein. (185 aa)
	DpseGA29007	Uncharacterized protein, isoform B. (393 aa)
	DpseGA25491	Uncharacterized protein, isoform C. (493 aa)
	DpseGA20908	Receptor protein-tyrosine kinase. (1649 aa)
	DpseGA27713	Uncharacterized protein, isoform B. (585 aa)
	A0A0R3NPB6	Wingless-type MMTV integration site family, member 7. (384 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NPB6	DpseGA22660	A0A0R3NPB6	B5DLC5	Wingless-type MMTV integration site family, member 7.	Uncharacterized protein, isoform H.	0.459
B5DW47	DpseGA20908	B5DW47	A0A0R3NSX3	Ras-related protein Ral-A.	Receptor protein-tyrosine kinase.	0.455
B5DW47	Q296A4	B5DW47	Q296A4	Ras-related protein Ral-A.	Uncharacterized protein, isoform A.	0.636
Cdc42	DpseGA13993	Q29HY3	Q29CU6	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	Uncharacterized protein.	0.532
Cdc42	DpseGA14356	Q29HY3	Q29MS7	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.462
Cdc42	DpseGA18811	Q29HY3	Q29N75	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	ELMO domain-containing protein.	0.665
Cdc42	I5ANT7	Q29HY3	I5ANT7	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	Dedicator of cytokinesis protein 1.	0.781
Cdc42	Q291A6	Q29HY3	Q291A6	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	E3 ubiquitin-protein ligase SH3RF.	0.408
Cdc42	syd	Q29HY3	Q29EP6	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	JNK-interacting protein 3; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK-signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Syd is required for efficient kinesin-I mediated axonal transport (By similarity).	0.451
DpseGA10222	DpseGA11484	Q2LZE9	Q29IJ2	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.964
DpseGA10370	DpseGA10461	Q2LYR0	Q2LZL7	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.732
DpseGA10370	DpseGA14958	Q2LYR0	Q29GL6	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Protein kinase domain-containing protein.	0.522
DpseGA10370	DpseGA22660	Q2LYR0	B5DLC5	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein, isoform H.	0.424
DpseGA10370	Q296A4	Q2LYR0	Q296A4	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein, isoform A.	0.404
DpseGA10461	DpseGA10370	Q2LZL7	Q2LYR0	UBIQUITIN_CONJUGAT_2 domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.732
DpseGA10461	DpseGA10670	Q2LZL7	Q29HD1	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein.	0.758
DpseGA10461	DpseGA14958	Q2LZL7	Q29GL6	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Protein kinase domain-containing protein.	0.554
DpseGA10461	DpseGA18154	Q2LZL7	A0A0R3P705	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein, isoform B.	0.543
DpseGA10461	DpseGA23680	Q2LZL7	A0A0R3P375	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein, isoform C.	0.540
DpseGA10461	DpseGA25491	Q2LZL7	A0A0R3NTJ4	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein, isoform C.	0.513