(29 nodes) Negative regulation of JNK cascade network (Drosophila pseudoobscura)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	DpseGA20319	Uncharacterized protein, isoform E. (744 aa)
	DpseGA23680	Uncharacterized protein, isoform C. (439 aa)
	DpseGA32911	Uncharacterized protein. (83 aa)
	DpseGA11051	Uncharacterized protein, isoform B. (929 aa)
	DpseGA21564	Uncharacterized protein, isoform C. (666 aa)
	DpseGA25391	Uncharacterized protein. (282 aa)
	DpseGA22660	Uncharacterized protein, isoform H. (880 aa)
	DpseGA22604	Uncharacterized protein, isoform A. (5496 aa)
	Urm1	Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Jafrac1, Ciao1, Eip71CD and GILT1. The thiocarboxylated form serves as substrate [...] (99 aa)
	DpseGA30839	Uncharacterized protein. (560 aa)
	B5DW47	Ras-related protein Ral-A. (200 aa)
	Q28X29	Capping protein (actin filament) muscle Z-line, alpha. (286 aa)
	Q298N6	Histone arginine demethylase JMJD6. (434 aa)
	Q298R5	LIM and senescent cell antigen-like-containing domain protein 1/2. (348 aa)
	Q29AF1	Uncharacterized protein. (199 aa)
	pont	RuvB-like helicase 1; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth (By similarity). (456 aa)
	Q29BV8	Uncharacterized protein, isoform E. (367 aa)
	DpseGA21595	Uncharacterized protein, isoform A. (570 aa)
	DpseGA11383	Ubiquitin carboxyl-terminal hydrolase. (829 aa)
	DpseGA15484	Uncharacterized protein. (201 aa)
	DpseGA11481	Uncharacterized protein. (1960 aa)
	DpseGA11484	Serine/threonine-protein phosphatase. (303 aa)
	DpseGA12826	Uncharacterized protein. (380 aa)
	DpseGA11633	Uncharacterized protein. (853 aa)
	DpseGA14356	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (276 aa)
	DpseGA17928	Uncharacterized protein. (694 aa)
	DpseGA12519	Uncharacterized protein. (787 aa)
	DpseGA10370	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (485 aa)
	DpseGA10222	Uncharacterized protein. (780 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DpseGA10222	DpseGA11484	Q2LZE9	Q29IJ2	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.964
DpseGA10370	DpseGA22660	Q2LYR0	B5DLC5	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein, isoform H.	0.424
DpseGA11051	DpseGA20319	A0A0R3P5T1	A0A0R3NZ13	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform E.	0.970
DpseGA11383	DpseGA22604	Q29E26	B5DLK9	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein, isoform A.	0.408
DpseGA11484	DpseGA10222	Q29IJ2	Q2LZE9	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.964
DpseGA11484	DpseGA32911	Q29IJ2	A0A0R3P4Y2	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.964
DpseGA14356	Q28X29	Q29MS7	Q28X29	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Capping protein (actin filament) muscle Z-line, alpha.	0.997
DpseGA17928	DpseGA30839	Q29N39	A0A0R3NXR4	Uncharacterized protein.	Uncharacterized protein.	0.901
DpseGA20319	DpseGA11051	A0A0R3NZ13	A0A0R3P5T1	Uncharacterized protein, isoform E.	Uncharacterized protein, isoform B.	0.970
DpseGA22604	DpseGA11383	B5DLK9	Q29E26	Uncharacterized protein, isoform A.	Ubiquitin carboxyl-terminal hydrolase.	0.408
DpseGA22660	DpseGA10370	B5DLC5	Q2LYR0	Uncharacterized protein, isoform H.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.424
DpseGA25391	Q298R5	B5DHC6	Q298R5	Uncharacterized protein.	LIM and senescent cell antigen-like-containing domain protein 1/2.	0.994
DpseGA30839	DpseGA17928	A0A0R3NXR4	Q29N39	Uncharacterized protein.	Uncharacterized protein.	0.901
DpseGA32911	DpseGA11484	A0A0R3P4Y2	Q29IJ2	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.964
Q28X29	DpseGA14356	Q28X29	Q29MS7	Capping protein (actin filament) muscle Z-line, alpha.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.997
Q298R5	DpseGA25391	Q298R5	B5DHC6	LIM and senescent cell antigen-like-containing domain protein 1/2.	Uncharacterized protein.	0.994