(30 nodes) Vascular endothelial growth factor receptor signaling pathway network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Q28ZT1	Growth factor receptor-binding protein 2. (211 aa)
	Q294V1	RAC serine/threonine-protein kinase. (530 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	Q296F4	Kinase suppressor of Ras 2. (1012 aa)
	Q29AY5	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta. (1112 aa)
	DpseGA13993	Uncharacterized protein. (297 aa)
	DpseGA10383	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
	DpseGA15321	Uncharacterized protein. (192 aa)
	DpseGA17637	Uncharacterized protein. (423 aa)
	DpseGA20849	Uncharacterized protein. (1100 aa)
	DpseGA20104	Uncharacterized protein, isoform A; Belongs to the PDGF/VEGF growth factor family. (323 aa)
	Cdc42	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity). (191 aa)
	DpseGA13960	Uncharacterized protein, isoform A. (524 aa)
	DpseGA15481	Uncharacterized protein, isoform A. (839 aa)
	DpseGA16878	Uncharacterized protein, isoform A. (487 aa)
	DpseGA21364	Uncharacterized protein. (121 aa)
	DpseGA16373	Uncharacterized protein, isoform A. (745 aa)
	DpseGA12522	Uncharacterized protein. (362 aa)
	DpseGA18811	ELMO domain-containing protein. (724 aa)
	A0A0R3NI60	Uncharacterized protein, isoform A. (767 aa)
	DpseGA12523	Uncharacterized protein, isoform E. (694 aa)
	DpseGA20908	Receptor protein-tyrosine kinase. (1649 aa)
	DpseGA32035	Protein kinase domain-containing protein. (157 aa)
	DpseGA18654	Uncharacterized protein, isoform B; Belongs to the PI3/PI4-kinase family. (2501 aa)
	DpseGA20666	Uncharacterized protein, isoform B. (983 aa)
	A0A158SUH3	Uncharacterized protein. (392 aa)
	DpseGA28770	Uncharacterized protein. (1618 aa)
	DpseGA22607	Uncharacterized protein, isoform A. (1248 aa)
	DpseGA28732	Uncharacterized protein. (207 aa)
	I5ANT7	Dedicator of cytokinesis protein 1. (2003 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NI60	A0A158SUH3	A0A0R3NI60	A0A158SUH3	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.432
A0A0R3NI60	DpseGA28770	A0A0R3NI60	B5DK13	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.432
A0A0R3NI60	Q28ZT1	A0A0R3NI60	Q28ZT1	Uncharacterized protein, isoform A.	Growth factor receptor-binding protein 2.	0.723
A0A0R3NI60	Q294V1	A0A0R3NI60	Q294V1	Uncharacterized protein, isoform A.	RAC serine/threonine-protein kinase.	0.440
A0A158SUH3	A0A0R3NI60	A0A158SUH3	A0A0R3NI60	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.432
A0A158SUH3	Cdc42	A0A158SUH3	Q29HY3	Uncharacterized protein.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	0.517
A0A158SUH3	DpseGA13960	A0A158SUH3	Q29IC0	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.414
A0A158SUH3	DpseGA13993	A0A158SUH3	Q29CU6	Uncharacterized protein.	Uncharacterized protein.	0.790
A0A158SUH3	DpseGA15321	A0A158SUH3	Q29EV6	Uncharacterized protein.	Uncharacterized protein.	0.517
A0A158SUH3	DpseGA15481	A0A158SUH3	Q29IQ6	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.522
A0A158SUH3	DpseGA17637	A0A158SUH3	Q29FA1	Uncharacterized protein.	Uncharacterized protein.	0.865
A0A158SUH3	DpseGA20666	A0A158SUH3	A0A0R3P0R0	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.610
A0A158SUH3	Q28ZT1	A0A158SUH3	Q28ZT1	Uncharacterized protein.	Growth factor receptor-binding protein 2.	0.967
A0A158SUH3	Q296F4	A0A158SUH3	Q296F4	Uncharacterized protein.	Kinase suppressor of Ras 2.	0.400
A0A158SUH3	Q29AY5	A0A158SUH3	Q29AY5	Uncharacterized protein.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.	0.657
A0A158SUH3	Ras85D	A0A158SUH3	Q295X7	Uncharacterized protein.	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.	0.653
Cdc42	A0A158SUH3	Q29HY3	A0A158SUH3	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	Uncharacterized protein.	0.517
Cdc42	DpseGA13960	Q29HY3	Q29IC0	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	Uncharacterized protein, isoform A.	0.472
Cdc42	DpseGA13993	Q29HY3	Q29CU6	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	Uncharacterized protein.	0.532
Cdc42	DpseGA17637	Q29HY3	Q29FA1	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	Uncharacterized protein.	0.415