(80 nodes) Negative regulation of developmental growth network (Drosophila pseudoobscura)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DpseGA16039	Uncharacterized protein, isoform D. (823 aa)
	B5DXC1	Disintegrin and metalloproteinase domain-containing protein 17. (743 aa)
	B5DYQ2	Relaxin family peptide receptor 2. (772 aa)
	B5DZT9	Uncharacterized protein, isoform A. (722 aa)
	B5E1J5	Uncharacterized protein, isoform A. (424 aa)
	I5AN96	Uncharacterized protein. (392 aa)
	I5APB1	Uncharacterized protein, isoform C. (1114 aa)
	I5APT4	Uncharacterized protein, isoform M. (1857 aa)
	N6W6G2	Voltage-dependent calcium channel alpha-2/delta-3. (1263 aa)
	Q28XI9	G protein-coupled receptor kinase interactor 2. (732 aa)
	Q28XT4	Uncharacterized protein, isoform D. (1186 aa)
	Q28Z44	Uncharacterized protein, isoform A. (774 aa)
	Q290C0	Anaphase-promoting complex subunit 2. (802 aa)
	Fsn	F-box/SPRY domain-containing protein 1; Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ); Belongs to the FBXO45/Fsn family. (255 aa)
	Q291T4	Uncharacterized protein. (799 aa)
	Dpse_fak	Focal adhesion kinase 1. (1530 aa)
	Q292Z2	Uncharacterized protein. (223 aa)
	Q294V1	RAC serine/threonine-protein kinase. (530 aa)
	Q295M0	Ras association domain-containing protein 7/8. (615 aa)
	Q296D8	Uncharacterized protein, isoform A. (578 aa)
	Q296J3	Uncharacterized protein. (849 aa)
	Q296P4	F-box and leucine-rich repeat protein 7. (787 aa)
	Q297F4	YTH domain-containing family protein. (641 aa)
	Q297H8	Mothers against decapentaplegic homolog 6. (584 aa)
	DpseGA29289	Uncharacterized protein, isoform E. (1078 aa)
	DpseGA19997	Rap-GAP domain-containing protein. (1864 aa)
	dbo	Kelch-like protein diablo; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth (By similarity). (628 aa)
	DpseGA20508	BHLH domain-containing protein. (412 aa)
	DpseGA19425	Uncharacterized protein, isoform C. (1065 aa)
	DpseGA10361	Uncharacterized protein, isoform A. (755 aa)
	DpseGA18860	Protein kinase domain-containing protein. (490 aa)
	DpseGA18943	Uncharacterized protein, isoform A; Belongs to the peptidase M16 family. (1034 aa)
	DpseGA14581	Integrin beta; Belongs to the integrin beta chain family. (804 aa)
	DpseGA17399	Uncharacterized protein, isoform B. (5256 aa)
	DpseGA17967	FERM domain-containing protein. (1515 aa)
	DpseGA11537	Uncharacterized protein. (388 aa)
	Sema-1a	Sema-1a, isoform D; Belongs to the semaphorin family. (854 aa)
	DpseGA20715	BZIP domain-containing protein. (465 aa)
	DpseGA17013	Uncharacterized protein, isoform B. (5568 aa)
	DpseGA12841	FERM domain-containing protein. (636 aa)
	DpseGA14843	Uncharacterized protein, isoform C. (1417 aa)
	DpseGA12831	Uncharacterized protein, isoform A. (1034 aa)
	DpseGA10179	Uncharacterized protein. (3708 aa)
	DpseGA18647	t-SNARE coiled-coil homology domain-containing protein. (284 aa)
	DpseGA21570	Uncharacterized protein. (704 aa)
	DpseGA13429	Uncharacterized protein. (1422 aa)
	DpseGA17894	Uncharacterized protein. (1860 aa)
	Q29CB7	Serine/threonine-protein kinase LATS1/2. (1143 aa)
	DpseGA13434	Uncharacterized protein, isoform G. (704 aa)
	DpseGA23503	Uncharacterized protein, isoform B. (1103 aa)
	DpseGA20737	Uncharacterized protein, isoform C. (1322 aa)
	DpseGA14413	Uncharacterized protein, isoform C. (849 aa)
	DpseGA11051	Uncharacterized protein, isoform B. (929 aa)
	DpseGA28338	Tyrosine-protein kinase. (552 aa)
	B5DX59	Uncharacterized protein. (2795 aa)
	B5DVY6	Scaffold protein salvador. (587 aa)
	B5DVF7	Uncharacterized protein. (1280 aa)
	DpseGA23289	Uncharacterized protein. (330 aa)
	DpseGA28339	Protein kinase domain-containing protein. (234 aa)
	DpseGA22660	Uncharacterized protein, isoform H. (880 aa)
	Q29BK0	Uncharacterized protein, isoform B. (525 aa)
	Q29BJ9	Neural Wiskott-Aldrich syndrome protein. (547 aa)
	Dpse_Tl	Protein toll. (1120 aa)
	Q299H7	Uncharacterized protein, isoform A. (572 aa)
	spas	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (788 aa)
	Q298J9	Uncharacterized protein, isoform A. (1107 aa)
	Q298B5	Forkhead box protein A2, hepatocyte nuclear factor 3-beta. (613 aa)
	Q297H9	DNA topoisomerase 2-associated protein PAT1. (979 aa)
	DpseGA32390	Raptor_N domain-containing protein. (1683 aa)
	DpseGA32929	Uncharacterized protein. (172 aa)
	DpseGA19047	Uncharacterized protein, isoform C. (503 aa)
	DpseGA10030	Uncharacterized protein, isoform E. (1397 aa)
	A0A0R3NS54	Tyrosine-protein kinase receptor torso. (939 aa)
	A0A0R3NPG2	Guanine nucleotide-binding protein G(o) subunit alpha. (354 aa)
	A0A0R3NNZ3	Uncharacterized protein, isoform A. (1711 aa)
	A0A0R3NMU4	Uncharacterized protein, isoform A. (3416 aa)
	A0A0R3NLP3	Fragile X mental retardation protein. (702 aa)
	A0A0R3NI42	Uncharacterized protein, isoform D. (2255 aa)
	A0A0R3NGZ0	Uncharacterized protein, isoform A. (465 aa)
	A0A0R3NFP7	Uncharacterized protein, isoform A. (843 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NI42	A0A0R3NMU4	A0A0R3NI42	A0A0R3NMU4	Uncharacterized protein, isoform D.	Uncharacterized protein, isoform A.	0.588
A0A0R3NI42	B5DVF7	A0A0R3NI42	B5DVF7	Uncharacterized protein, isoform D.	Uncharacterized protein.	0.502
A0A0R3NI42	DpseGA17967	A0A0R3NI42	Q29N45	Uncharacterized protein, isoform D.	FERM domain-containing protein.	0.971
A0A0R3NI42	spas	A0A0R3NI42	Q298L4	Uncharacterized protein, isoform D.	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily.	0.406
A0A0R3NLP3	DpseGA19425	A0A0R3NLP3	Q2LZ44	Fragile X mental retardation protein.	Uncharacterized protein, isoform C.	0.426
A0A0R3NMU4	A0A0R3NI42	A0A0R3NMU4	A0A0R3NI42	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform D.	0.588
A0A0R3NMU4	B5E1J5	A0A0R3NMU4	B5E1J5	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.470
A0A0R3NMU4	DpseGA10030	A0A0R3NMU4	A0A0R3NUE9	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform E.	0.555
A0A0R3NMU4	DpseGA14413	A0A0R3NMU4	A0A0R3P5M2	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform C.	0.652
A0A0R3NMU4	DpseGA23289	A0A0R3NMU4	B5DV00	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.652
A0A0R3NNZ3	A0A0R3NPG2	A0A0R3NNZ3	A0A0R3NPG2	Uncharacterized protein, isoform A.	Guanine nucleotide-binding protein G(o) subunit alpha.	0.453
A0A0R3NNZ3	DpseGA10030	A0A0R3NNZ3	A0A0R3NUE9	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform E.	0.558
A0A0R3NNZ3	DpseGA14581	A0A0R3NNZ3	Q29NR4	Uncharacterized protein, isoform A.	Integrin beta; Belongs to the integrin beta chain family.	0.429
A0A0R3NNZ3	DpseGA19047	A0A0R3NNZ3	A0A0R3NW51	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform C.	0.639
A0A0R3NNZ3	Dpse_fak	A0A0R3NNZ3	Q292S0	Uncharacterized protein, isoform A.	Focal adhesion kinase 1.	0.804
A0A0R3NNZ3	I5APB1	A0A0R3NNZ3	I5APB1	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform C.	0.883
A0A0R3NNZ3	Q294V1	A0A0R3NNZ3	Q294V1	Uncharacterized protein, isoform A.	RAC serine/threonine-protein kinase.	0.639
A0A0R3NNZ3	Q298J9	A0A0R3NNZ3	Q298J9	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.478
A0A0R3NPG2	A0A0R3NNZ3	A0A0R3NPG2	A0A0R3NNZ3	Guanine nucleotide-binding protein G(o) subunit alpha.	Uncharacterized protein, isoform A.	0.453
A0A0R3NPG2	DpseGA20737	A0A0R3NPG2	A0A0R3P562	Guanine nucleotide-binding protein G(o) subunit alpha.	Uncharacterized protein, isoform C.	0.431