(52 nodes) Regulation of axonogenesis network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	B5DZT9	Uncharacterized protein, isoform A. (722 aa)
	I5APA0	annotation not available (889 aa)
	I5APW3	annotation not available (1868 aa)
	N6W635	Nuclear receptor subfamily 2 group E member 3. (579 aa)
	N6WBU9	Uncharacterized protein. (616 aa)
	Dpse_eve	Homeobox even-skipped homolog protein. (359 aa)
	Q28Z44	Uncharacterized protein, isoform A. (774 aa)
	Lis-1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. (411 aa)
	Q291T4	Uncharacterized protein. (799 aa)
	Dpse_Pak3	P21-activated kinase 1. (586 aa)
	Q297F4	YTH domain-containing family protein. (641 aa)
	spas	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (788 aa)
	Q29BY7	Uncharacterized protein. (542 aa)
	DpseGA14409	Sema domain-containing protein. (2071 aa)
	DpseGA19569	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (612 aa)
	DpseGA10747	Sema domain-containing protein. (1636 aa)
	DpseGA21999	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (818 aa)
	DpseGA10060	Uncharacterized protein. (531 aa)
	DpseGA20834	Uncharacterized protein, isoform C. (1380 aa)
	DpseGA15321	Uncharacterized protein. (192 aa)
	A0A0R3NVE4	Cadherin EGF LAG seven-pass G-type receptor 1. (3626 aa)
	DpseGA19383	Uncharacterized protein, isoform B. (746 aa)
	A0A0R3NTR6	Rho guanine nucleotide exchange factor 12. (2671 aa)
	Dpse_Dscam	Dscam, isoform B. (2049 aa)
	A0A0R3NN44	Uncharacterized protein, isoform A. (8901 aa)
	A0A0R3NLS0	annotation not available (890 aa)
	A0A0R3NLP3	Fragile X mental retardation protein. (702 aa)
	A0A0R3NLL7	Uncharacterized protein, isoform F. (1295 aa)
	DpseGA28275	Uncharacterized protein, isoform C. (2224 aa)
	DpseGA21612	CAP-Gly domain-containing protein. (1262 aa)
	DpseGA14615	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (619 aa)
	DpseGA20508	BHLH domain-containing protein. (412 aa)
	DpseGA21874	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	DpseGA11537	Uncharacterized protein. (388 aa)
	Sema-1a	Sema-1a, isoform D; Belongs to the semaphorin family. (854 aa)
	DpseGA14953	Uncharacterized protein, isoform A. (1302 aa)
	DpseGA13122	Uncharacterized protein. (1496 aa)
	DpseGA22026	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1388 aa)
	DpseGA22113	Uncharacterized protein. (368 aa)
	Cdc42	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity). (191 aa)
	DpseGA30672	Uncharacterized protein, isoform B. (60 aa)
	DpseGA22812	Uncharacterized protein, isoform B. (1637 aa)
	DpseGA23503	Uncharacterized protein, isoform B. (1103 aa)
	Rpd3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (554 aa)
	DpseGA28238	Uncharacterized protein. (327 aa)
	DpseGA18858	Uncharacterized protein. (2778 aa)
	DpseGA22604	Uncharacterized protein, isoform A. (5496 aa)
	DpseGA23612	Uncharacterized protein. (192 aa)
	DpseGA28239	Uncharacterized protein. (295 aa)
	B5DZ84	Uncharacterized protein, isoform A. (205 aa)
	DpseGA14843	Uncharacterized protein, isoform C. (1417 aa)
	DpseGA14904	Uncharacterized protein. (618 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NLL7	DpseGA14953	A0A0R3NLL7	Q29J73	Uncharacterized protein, isoform F.	Uncharacterized protein, isoform A.	0.669
A0A0R3NN44	B5DZ84	A0A0R3NN44	B5DZ84	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform A.	0.692
A0A0R3NN44	Cdc42	A0A0R3NN44	Q29HY3	Uncharacterized protein, isoform A.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	0.422
A0A0R3NN44	DpseGA15321	A0A0R3NN44	Q29EV6	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.422
A0A0R3NN44	DpseGA23612	A0A0R3NN44	B5DQJ0	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.422
A0A0R3NN44	Dpse_Pak3	A0A0R3NN44	Q295W7	Uncharacterized protein, isoform A.	P21-activated kinase 1.	0.473
A0A0R3NN44	I5APA0	A0A0R3NN44	I5APA0	Uncharacterized protein, isoform A.	annotation not available	0.473
A0A0R3NTR6	B5DZ84	A0A0R3NTR6	B5DZ84	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform A.	0.968
A0A0R3NTR6	Cdc42	A0A0R3NTR6	Q29HY3	Rho guanine nucleotide exchange factor 12.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	0.709
A0A0R3NTR6	DpseGA10747	A0A0R3NTR6	Q29CU7	Rho guanine nucleotide exchange factor 12.	Sema domain-containing protein.	0.661
A0A0R3NTR6	DpseGA14409	A0A0R3NTR6	Q29CL9	Rho guanine nucleotide exchange factor 12.	Sema domain-containing protein.	0.661
A0A0R3NTR6	DpseGA15321	A0A0R3NTR6	Q29EV6	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein.	0.744
A0A0R3NTR6	DpseGA18858	A0A0R3NTR6	A0A0R3P804	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein.	0.593
A0A0R3NTR6	DpseGA20834	A0A0R3NTR6	Q29EP3	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform C.	0.666
A0A0R3NTR6	DpseGA22026	A0A0R3NTR6	Q29IT7	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.584
A0A0R3NTR6	DpseGA22812	A0A0R3NTR6	A0A0R3P3J5	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform B.	0.466
A0A0R3NTR6	DpseGA23612	A0A0R3NTR6	B5DQJ0	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein.	0.682
A0A0R3NTR6	DpseGA28275	A0A0R3NTR6	B5DRR3	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform C.	0.766
A0A0R3NTR6	DpseGA30672	A0A0R3NTR6	A0A0R3NWJ5	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform B.	0.766
A0A0R3NVE4	DpseGA14615	A0A0R3NVE4	Q2LZT5	Cadherin EGF LAG seven-pass G-type receptor 1.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.717