(110 nodes) Regulation of behavior network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DpseGA30007	Uncharacterized protein, isoform G. (378 aa)
	A0A0R3NLP3	Fragile X mental retardation protein. (702 aa)
	A0A0R3NLV2	Aquaporin rerated protein, invertebrate. (244 aa)
	A0A0R3NMA5	Uncharacterized protein, isoform D. (1822 aa)
	A0A0R3NQ45	Uncharacterized protein, isoform B. (158 aa)
	DpseGA25303	Angiotensin-converting enzyme. (633 aa)
	DpseGA25382	Uncharacterized protein, isoform C. (448 aa)
	DpseGA12042	Uncharacterized protein, isoform C. (148 aa)
	DpseGA31637	BTB domain-containing protein. (97 aa)
	DpseGA19383	Uncharacterized protein, isoform B. (746 aa)
	DpseGA14860	Uncharacterized protein, isoform B. (764 aa)
	DpseGA12508	Uncharacterized protein, isoform B; Belongs to the G-protein coupled receptor 2 family. (764 aa)
	DpseGA17599	Uncharacterized protein, isoform D. (891 aa)
	DpseGA18232	Uncharacterized protein, isoform B. (718 aa)
	DpseGA16721	Uncharacterized protein, isoform X. (1362 aa)
	DpseGA29217	Uncharacterized protein, isoform B; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (2304 aa)
	DpseGA26555	Uncharacterized protein, isoform C; Belongs to the potassium channel family. (764 aa)
	DpseGA21284	Uncharacterized protein, isoform B. (434 aa)
	DpseGA28469	Uncharacterized protein, isoform D. (471 aa)
	DpseGA25348	Uncharacterized protein, isoform A. (419 aa)
	DpseGA25353	BTB domain-containing protein. (380 aa)
	DpseGA25355	BTB domain-containing protein. (420 aa)
	DpseGA25289	Uncharacterized protein, isoform A. (196 aa)
	DpseGA25262	Uncharacterized protein, isoform A. (378 aa)
	DpseGA25630	BTB domain-containing protein. (373 aa)
	DpseGA25415	BTB domain-containing protein. (375 aa)
	DpseGA25234	BTB domain-containing protein. (303 aa)
	DpseGA25481	Uncharacterized protein, isoform B. (158 aa)
	DpseGA27747	Rhomboid domain-containing protein. (1443 aa)
	DpseGA25913	Uncharacterized protein. (399 aa)
	DpseGA28812	BTB domain-containing protein. (372 aa)
	DpseGA22782	Uncharacterized protein, isoform A. (643 aa)
	DpseGA26564	Ion_trans domain-containing protein; Belongs to the potassium channel family. (171 aa)
	DpseGA23358	BTB domain-containing protein. (424 aa)
	DpseGA22328	Uncharacterized protein, isoform A. (318 aa)
	DpseGA23526	BTB domain-containing protein. (369 aa)
	DpseGA23817	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (420 aa)
	DpseGA23523	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (835 aa)
	DpseGA23678	Uncharacterized protein. (2167 aa)
	DpseGA28500	Uncharacterized protein, isoform A. (291 aa)
	DpseGA28532	Uncharacterized protein, isoform A. (415 aa)
	DpseGA22214	Uncharacterized protein. (121 aa)
	DpseGA22550	BTB domain-containing protein. (369 aa)
	B5DXL4	Uncharacterized protein. (916 aa)
	B5DYR5	Insulin-like growth factor 1 receptor. (2293 aa)
	B5DZ84	Uncharacterized protein, isoform A. (205 aa)
	qvr	Protein quiver; Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability (By similarity). (159 aa)
	B5E0K8	Uncharacterized protein, isoform C. (168 aa)
	B5E0V6	Uncharacterized protein, isoform C. (193 aa)
	B5E199	Uncharacterized protein. (72 aa)
	B5E1M6	Uncharacterized protein, isoform A. (899 aa)
	I5AN79	Uncharacterized protein. (731 aa)
	I5ANU3	Uncharacterized protein. (512 aa)
	Hsp83	Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for piRNA biogenesis by facilitating loading of piRNAs into PIW [...] (717 aa)
	Est-5C	Esterase-5C; Belongs to the type-B carboxylesterase/lipase family. (545 aa)
	Est-5B	Esterase-5B. (545 aa)
	Est-5A	Esterase-5A; Belongs to the type-B carboxylesterase/lipase family. (548 aa)
	Q28WN9	Uncharacterized protein, isoform C. (1744 aa)
	Dpse_EcR	Ecdysone receptor. (700 aa)
	Q28X53	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2. (1309 aa)
	Q28XI6	Uncharacterized protein. (248 aa)
	Q28ZU1	Eukaryotic translation initiation factor 2C. (985 aa)
	Q28ZW5	Potassium channel subfamily K member 18. (396 aa)
	Q28ZX9	RNA polymerase II-associated protein 3. (573 aa)
	Q290U6	Uncharacterized protein, isoform B. (844 aa)
	Dpse_Gr43a	Gustatory receptor. (427 aa)
	Q292T6	Growth arrest and DNA-damage-inducible protein. (160 aa)
	cry	Cryptochrome-1; Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Light induces the degradation of cry, likely due to conformational change in the photoreceptor leading to targeting to the proteasome. Under circadian regulation, expression is influenced by the clock pacemaker genes period, timeless, Clock and cycle. Binding to tim irreversibly commits tim to proteasomal degra [...] (540 aa)
	Q295X2	Uncharacterized protein. (1770 aa)
	Q296F8	Inositol 1,4,5-triphosphate receptor type 1. (2864 aa)
	Q296R1	5-hydroxytryptamine receptor 2. (944 aa)
	Q298P6	Uncharacterized protein. (97 aa)
	Q299E5	BTB/POZ domain-containing protein KCTD8/12/16. (228 aa)
	Q29AY5	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta. (1112 aa)
	Q29BV5	Dopamine receptor D1-like. (846 aa)
	Q29C04	Ets translocation variant 5. (643 aa)
	DpseGA17075	Aldo_ket_red domain-containing protein. (934 aa)
	DpseGA10423	Angiotensin-converting enzyme. (633 aa)
	DpseGA17148	TMC domain-containing protein. (2051 aa)
	DpseGA21560	Uncharacterized protein, isoform A. (572 aa)
	DpseGA20318	Uncharacterized protein. (1037 aa)
	DpseGA15321	Uncharacterized protein. (192 aa)
	cue	Protein cueball; Has a role in spermatogenesis and oogenesis. Belongs to the cueball family. (647 aa)
	rho	Rho; Belongs to the peptidase S54 family. (373 aa)
	DpseGA20611	Protein kinase domain-containing protein. (915 aa)
	DpseGA14916	F-box domain-containing protein. (675 aa)
	DpseGA21947	Uncharacterized protein, isoform A. (457 aa)
	DpseGA14299	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	DpseGA15409	Uncharacterized protein. (268 aa)
	SPR	Sex peptide receptor, isoform A. (504 aa)
	DpseGA18240	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (1141 aa)
	DpseGA17157	BTB domain-containing protein. (213 aa)
	DpseGA18225	AMP-binding domain-containing protein. (666 aa)
	DpseGA18224	AMP-binding domain-containing protein. (689 aa)
	DpseGA16511	Uncharacterized protein, isoform C; Belongs to the cullin family. (902 aa)
	DpseGA18743	Deacetylase sirtuin-type domain-containing protein. (878 aa)
	DpseGA18149	Uncharacterized protein, isoform A. (642 aa)
	DpseGA13352	Uncharacterized protein, isoform A. (121 aa)
	DpseGA14394	Rhomboid domain-containing protein. (252 aa)
	DpseGA16835	TIMELESS domain-containing protein. (1238 aa)
	DpseGA18145	Uncharacterized protein, isoform C; Belongs to the protein kinase superfamily. (353 aa)
	DpseGA15435	Uncharacterized protein. (515 aa)
	DpseGA10919	WH1 domain-containing protein. (566 aa)
	DpseGA17471	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (604 aa)
	DpseGA18943	Uncharacterized protein, isoform A; Belongs to the peptidase M16 family. (1034 aa)
	DpseGA10370	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (485 aa)
	DpseGA19609	Uncharacterized protein. (211 aa)
	DpseGA12316	Uncharacterized protein. (177 aa)
	DpseGA20356	Uncharacterized protein, isoform C. (571 aa)
	DpseGA20322	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (616 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NLP3	Q28ZU1	A0A0R3NLP3	Q28ZU1	Fragile X mental retardation protein.	Eukaryotic translation initiation factor 2C.	0.751
A0A0R3NLV2	DpseGA30007	A0A0R3NLV2	Q2M150	Aquaporin rerated protein, invertebrate.	Uncharacterized protein, isoform G.	0.415
A0A0R3NMA5	DpseGA14916	A0A0R3NMA5	Q29GN3	Uncharacterized protein, isoform D.	F-box domain-containing protein.	0.445
B5DYR5	B5E1M6	B5DYR5	B5E1M6	Insulin-like growth factor 1 receptor.	Uncharacterized protein, isoform A.	0.478
B5DYR5	DpseGA15435	B5DYR5	Q29NX3	Insulin-like growth factor 1 receptor.	Uncharacterized protein.	0.980
B5DYR5	DpseGA18743	B5DYR5	Q29L51	Insulin-like growth factor 1 receptor.	Deacetylase sirtuin-type domain-containing protein.	0.416
B5DYR5	DpseGA22328	B5DYR5	B5DNM9	Insulin-like growth factor 1 receptor.	Uncharacterized protein, isoform A.	0.400
B5DYR5	Dpse_EcR	B5DYR5	Q28WY6	Insulin-like growth factor 1 receptor.	Ecdysone receptor.	0.478
B5DYR5	Q29AY5	B5DYR5	Q29AY5	Insulin-like growth factor 1 receptor.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.	0.958
B5DZ84	DpseGA15321	B5DZ84	Q29EV6	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.794
B5DZ84	DpseGA15435	B5DZ84	Q29NX3	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.696
B5DZ84	DpseGA16511	B5DZ84	Q29KT9	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform C; Belongs to the cullin family.	0.637
B5DZ84	DpseGA16721	B5DZ84	A0A0R3P355	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform X.	0.703
B5DZ84	Hsp83	B5DZ84	P04809	Uncharacterized protein, isoform A.	Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for piRNA biogenesis by facilitating loading of piRNAs into PIW [...]	0.512
B5DZ84	Q29AY5	B5DZ84	Q29AY5	Uncharacterized protein, isoform A.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta.	0.530
B5E0K8	DpseGA17075	B5E0K8	Q29CI3	Uncharacterized protein, isoform C.	Aldo_ket_red domain-containing protein.	0.555
B5E1M6	B5DYR5	B5E1M6	B5DYR5	Uncharacterized protein, isoform A.	Insulin-like growth factor 1 receptor.	0.478
B5E1M6	DpseGA20318	B5E1M6	Q29EN9	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.409
B5E1M6	Dpse_EcR	B5E1M6	Q28WY6	Uncharacterized protein, isoform A.	Ecdysone receptor.	0.900
DpseGA10370	DpseGA18232	Q2LYR0	A0A0R3P2K3	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein, isoform B.	0.999