(31 nodes) Neuron cellular homeostasis network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DpseGA10370	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (485 aa)
	A0A0R3NMI5	Uncharacterized protein, isoform A. (314 aa)
	A0A0R3NQ07	Uncharacterized protein, isoform C. (883 aa)
	DpseGA14074	Uncharacterized protein, isoform B. (1736 aa)
	DpseGA30839	Uncharacterized protein. (560 aa)
	DpseGA23482	Uncharacterized protein, isoform F. (698 aa)
	DpseGA31031	Uncharacterized protein. (1892 aa)
	DpseGA23604	Uncharacterized protein. (4564 aa)
	DpseGA19562	Uncharacterized protein, isoform D. (255 aa)
	DpseGA22832	Uncharacterized protein. (745 aa)
	DpseGA27758	Uncharacterized protein. (371 aa)
	B5DYA3	Uncharacterized protein. (566 aa)
	B5E1J5	Uncharacterized protein, isoform A. (424 aa)
	I5ANU3	Uncharacterized protein. (512 aa)
	Q28WX1	Bcl-2-related ovarian killer protein. (302 aa)
	Q28ZB3	5'-AMP-activated protein kinase, regulatory beta subunit. (337 aa)
	Q290F5	Apoptotic protease-activating factor. (1489 aa)
	Q291U3	Solute carrier family 6 (neurotransmitter transporter, dopamine) member 3. (647 aa)
	Q295G3	Uncharacterized protein, isoform B. (1156 aa)
	Manf	Mesencephalic astrocyte-derived neurotrophic factor homolog; Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels (By similarity); Belongs to the ARMET family. (173 aa)
	Q29BP0	Uncharacterized protein. (559 aa)
	Q29BV5	Dopamine receptor D1-like. (846 aa)
	Q29CB8	Uncharacterized protein. (200 aa)
	DpseGA10795	Uncharacterized protein, isoform A. (1624 aa)
	DpseGA20363	t-SNARE coiled-coil homology domain-containing protein. (303 aa)
	DpseGA15729	Uncharacterized protein. (339 aa)
	sesB	SesB, isoform A; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa)
	DpseGA18225	AMP-binding domain-containing protein. (666 aa)
	DpseGA18224	AMP-binding domain-containing protein. (689 aa)
	DpseGA18269	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1301 aa)
	DpseGA17928	Uncharacterized protein. (694 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B5DYA3	Q29BP0	B5DYA3	Q29BP0	Uncharacterized protein.	Uncharacterized protein.	0.905
B5E1J5	DpseGA27758	B5E1J5	B5DVE3	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.967
DpseGA10370	Q29CB8	Q2LYR0	Q29CB8	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein.	0.930
DpseGA14074	DpseGA23604	A0A0R3NVX8	A0A0R3P372	Uncharacterized protein, isoform B.	Uncharacterized protein.	0.902
DpseGA17928	DpseGA30839	Q29N39	A0A0R3NXR4	Uncharacterized protein.	Uncharacterized protein.	0.901
DpseGA18224	DpseGA18225	Q29KA1	Q29K99	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.941
DpseGA18225	DpseGA18224	Q29K99	Q29KA1	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.941
DpseGA18269	I5ANU3	Q29N33	I5ANU3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Uncharacterized protein.	0.408
DpseGA18269	Q29BV5	Q29N33	Q29BV5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Dopamine receptor D1-like.	0.439
DpseGA19562	Q295G3	A0A0R3P6B6	Q295G3	Uncharacterized protein, isoform D.	Uncharacterized protein, isoform B.	0.557
DpseGA20363	DpseGA22832	Q29EC9	B5DKI8	t-SNARE coiled-coil homology domain-containing protein.	Uncharacterized protein.	0.780
DpseGA22832	DpseGA20363	B5DKI8	Q29EC9	Uncharacterized protein.	t-SNARE coiled-coil homology domain-containing protein.	0.780
DpseGA23604	DpseGA14074	A0A0R3P372	A0A0R3NVX8	Uncharacterized protein.	Uncharacterized protein, isoform B.	0.902
DpseGA27758	B5E1J5	B5DVE3	B5E1J5	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.967
DpseGA30839	DpseGA17928	A0A0R3NXR4	Q29N39	Uncharacterized protein.	Uncharacterized protein.	0.901
I5ANU3	DpseGA18269	I5ANU3	Q29N33	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.408
I5ANU3	Q29BV5	I5ANU3	Q29BV5	Uncharacterized protein.	Dopamine receptor D1-like.	0.916
Q28WX1	Q290F5	Q28WX1	Q290F5	Bcl-2-related ovarian killer protein.	Apoptotic protease-activating factor.	0.851
Q290F5	Q28WX1	Q290F5	Q28WX1	Apoptotic protease-activating factor.	Bcl-2-related ovarian killer protein.	0.851
Q295G3	DpseGA19562	Q295G3	A0A0R3P6B6	Uncharacterized protein, isoform B.	Uncharacterized protein, isoform D.	0.557