(41 nodes) Cortical cytoskeleton network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DpseGA23590	Uncharacterized protein. (1640 aa)
	DpseGA28577	Uncharacterized protein. (418 aa)
	DpseGA25771	Uncharacterized protein. (426 aa)
	DpseGA25826	Uncharacterized protein. (421 aa)
	DpseGA15168	Uncharacterized protein, isoform C. (2464 aa)
	DpseGA23508	Uncharacterized protein. (1137 aa)
	DpseGA23604	Uncharacterized protein. (4564 aa)
	DpseGA10833	Uncharacterized protein. (1210 aa)
	l(2)gl	Protein lethal(2) giant larvae; Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk (By similarity). Could act as a tumor suppressor. (1166 aa)
	DpseGA21874	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
	DpseGA10369	Uncharacterized protein. (1855 aa)
	A0A0R3NTR6	Rho guanine nucleotide exchange factor 12. (2671 aa)
	N6W683	Uncharacterized protein, isoform A. (1250 aa)
	N6V8K2	Uncharacterized protein, isoform K. (2244 aa)
	I5ANJ3	Uncharacterized protein. (1832 aa)
	B5DZB4	Kynurenine 3-monooxygenase. (473 aa)
	B5DZ16	Uncharacterized protein, isoform A. (1655 aa)
	B5DYK2	Uncharacterized protein. (419 aa)
	DpseGA29181	EF-hand domain-containing protein. (111 aa)
	DpseGA23973	Uncharacterized protein. (116 aa)
	DpseGA23310	Uncharacterized protein. (220 aa)
	DpseGA16333	Uncharacterized protein, isoform B. (670 aa)
	DpseGA28810	Uncharacterized protein, isoform D. (408 aa)
	DpseGA19192	Spectrin beta chain; Belongs to the spectrin family. (2308 aa)
	DpseGA22263	Uncharacterized protein, isoform D. (1889 aa)
	DpseGA11464	Uncharacterized protein, isoform C. (1346 aa)
	Q28ZF8	Actin-binding protein anillin. (1579 aa)
	Q28ZR4	Calcium and integrin-binding protein 2. (189 aa)
	Q293K0	Uncharacterized protein, isoform A. (563 aa)
	Q293W7	Regulating synaptic membrane exocytosis protein 2. (2906 aa)
	DpseGA20973	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (464 aa)
	DpseGA10524	WD_REPEATS_REGION domain-containing protein. (608 aa)
	DpseGA11331	Uncharacterized protein, isoform E. (4384 aa)
	DpseGA19933	ADF-H domain-containing protein. (163 aa)
	DpseGA17546	Uncharacterized protein, isoform A. (174 aa)
	GA15215	LanC-like protein 3 homolog; Belongs to the LanC-like protein family. (420 aa)
	v	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (380 aa)
	DpseGA17047	Uncharacterized protein. (2886 aa)
	DpseGA18143	Uncharacterized protein, isoform D. (917 aa)
	DpseGA18046	Uncharacterized protein. (949 aa)
	DpseGA24002	Rho-GAP domain-containing protein. (441 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NTR6	DpseGA10369	A0A0R3NTR6	Q2M0M0	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein.	0.489
A0A0R3NTR6	DpseGA17546	A0A0R3NTR6	Q29GG1	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform A.	0.449
B5DZB4	DpseGA21874	B5DZB4	Q29PL9	Kynurenine 3-monooxygenase.	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.492
B5DZB4	DpseGA23590	B5DZB4	B5DPB2	Kynurenine 3-monooxygenase.	Uncharacterized protein.	0.420
B5DZB4	v	B5DZB4	Q29I03	Kynurenine 3-monooxygenase.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.721
DpseGA10369	A0A0R3NTR6	Q2M0M0	A0A0R3NTR6	Uncharacterized protein.	Rho guanine nucleotide exchange factor 12.	0.489
DpseGA10369	DpseGA17546	Q2M0M0	Q29GG1	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.475
DpseGA10369	DpseGA20973	Q2M0M0	Q29D43	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.669
DpseGA10369	DpseGA23590	Q2M0M0	B5DPB2	Uncharacterized protein.	Uncharacterized protein.	0.943
DpseGA10369	N6W683	Q2M0M0	N6W683	Uncharacterized protein.	Uncharacterized protein, isoform A.	0.991
DpseGA10369	Q28ZF8	Q2M0M0	Q28ZF8	Uncharacterized protein.	Actin-binding protein anillin.	0.991
DpseGA10524	DpseGA18143	Q29DL4	Q29J93	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein, isoform D.	0.454
DpseGA10524	DpseGA20973	Q29DL4	Q29D43	WD_REPEATS_REGION domain-containing protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.451
DpseGA10524	DpseGA21874	Q29DL4	Q29PL9	WD_REPEATS_REGION domain-containing protein.	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.668
DpseGA10833	DpseGA11464	Q29P18	A0A0R3P2S4	Uncharacterized protein.	Uncharacterized protein, isoform C.	0.919
DpseGA10833	I5ANJ3	Q29P18	I5ANJ3	Uncharacterized protein.	Uncharacterized protein.	0.876
DpseGA10833	N6V8K2	Q29P18	N6V8K2	Uncharacterized protein.	Uncharacterized protein, isoform K.	0.846
DpseGA10833	Q293W7	Q29P18	Q293W7	Uncharacterized protein.	Regulating synaptic membrane exocytosis protein 2.	0.994
DpseGA11331	DpseGA15168	Q29DQ8	A0A0R3P5T5	Uncharacterized protein, isoform E.	Uncharacterized protein, isoform C.	0.960
DpseGA11331	DpseGA23604	Q29DQ8	A0A0R3P372	Uncharacterized protein, isoform E.	Uncharacterized protein.	0.850