(90 nodes) CDC42 GTPase cycle network (Drosophila pseudoobscura)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A0R3NMU4	Uncharacterized protein, isoform A. (3416 aa)
	A0A0R3NKH8	Uncharacterized protein, isoform B. (1291 aa)
	A0A0R3NHX1	Rho GTPase-activating protein SYDE. (1882 aa)
	A0A0R3NHI5	Uncharacterized protein, isoform A. (2503 aa)
	A0A0R3NHH7	Diphthamide biosynthesis protein 4. (193 aa)
	A0A0R3NFM3	Uncharacterized protein, isoform C. (441 aa)
	Q28ZY7	Serine/threonine-protein kinase MRCK. (1646 aa)
	DpseGA22567	DH domain-containing protein. (2269 aa)
	DpseGA28222	Uncharacterized protein. (422 aa)
	DpseGA23068	PHB domain-containing protein. (397 aa)
	DpseGA23678	Uncharacterized protein. (2167 aa)
	DpseGA28506	Uncharacterized protein. (114 aa)
	DpseGA30018	Uncharacterized protein. (163 aa)
	DpseGA28232	Uncharacterized protein. (151 aa)
	DpseGA28230	Uncharacterized protein. (119 aa)
	DpseGA28275	Uncharacterized protein, isoform C. (2224 aa)
	DpseGA24002	Rho-GAP domain-containing protein. (441 aa)
	DpseGA23310	Uncharacterized protein. (220 aa)
	DpseGA29336	Rho-GAP domain-containing protein. (590 aa)
	DpseGA23973	Uncharacterized protein. (116 aa)
	DpseGA22249	Uncharacterized protein, isoform A. (91 aa)
	DpseGA29225	Uncharacterized protein. (207 aa)
	B5DX92	Uncharacterized protein. (643 aa)
	B5DXQ2	Rho GTPase-activating protein 39. (1376 aa)
	B5DY72	FERM, RhoGEF and pleckstrin domain protein 2. (4323 aa)
	I5AP65	Synaptosomal-associated protein 25. (213 aa)
	N6V9B2	Golgin subfamily A member 2. (780 aa)
	N6WBU9	Uncharacterized protein. (616 aa)
	N6WD43	Uncharacterized protein, isoform B. (883 aa)
	Q28WX8	Uncharacterized protein, isoform A. (1384 aa)
	Q28XD8	Uncharacterized protein. (508 aa)
	Q28XD9	Uncharacterized protein. (679 aa)
	Q28XI9	G protein-coupled receptor kinase interactor 2. (732 aa)
	Q28XY8	Rac GTPase-activating protein 1. (624 aa)
	DpseGA28748	Uncharacterized protein, isoform A. (469 aa)
	DpseGA25321	Uncharacterized protein. (184 aa)
	DpseGA28633	Uncharacterized protein. (113 aa)
	DpseGA12597	Uncharacterized protein. (2577 aa)
	DpseGA16664	Uncharacterized protein, isoform D. (1125 aa)
	DpseGA28300	Uncharacterized protein, isoform E. (209 aa)
	DpseGA28530	Uncharacterized protein. (191 aa)
	DpseGA16706	Uncharacterized protein, isoform E. (1186 aa)
	DpseGA18858	Uncharacterized protein. (2778 aa)
	DpseGA31783	Uncharacterized protein. (102 aa)
	DpseGA17694	Uncharacterized protein, isoform D. (2101 aa)
	DpseGA32255	DH domain-containing protein. (511 aa)
	DpseGA20609	Uncharacterized protein, isoform B. (204 aa)
	DpseGA22233	Uncharacterized protein, isoform B. (527 aa)
	DpseGA13434	Uncharacterized protein, isoform G. (704 aa)
	DpseGA19201	Uncharacterized protein, isoform B. (369 aa)
	DpseGA22812	Uncharacterized protein, isoform B. (1637 aa)
	DpseGA23702	Uncharacterized protein, isoform B. (478 aa)
	DpseGA22300	Uncharacterized protein, isoform B. (592 aa)
	DpseGA20666	Uncharacterized protein, isoform B. (983 aa)
	DpseGA22873	Uncharacterized protein, isoform B. (1416 aa)
	DpseGA30672	Uncharacterized protein, isoform B. (60 aa)
	DpseGA10691	Uncharacterized protein, isoform F. (1159 aa)
	DpseGA10030	Uncharacterized protein, isoform E. (1397 aa)
	A0A0R3NTR6	Rho guanine nucleotide exchange factor 12. (2671 aa)
	DpseGA25909	Uncharacterized protein, isoform H. (1525 aa)
	DpseGA19738	Uncharacterized protein, isoform J; Belongs to the DOCK family. (2316 aa)
	DpseGA10957	Uncharacterized protein, isoform B; Belongs to the DOCK family. (2073 aa)
	Q299H2	Synaptosomal-associated protein 25. (211 aa)
	Q299I6	BTB/POZ domain-containing protein KCTD3. (751 aa)
	DpseGA11994	Uncharacterized protein, isoform A. (191 aa)
	Q28Z49	Uncharacterized protein, isoform B. (843 aa)
	Q28ZM7	Uncharacterized protein, isoform D. (1622 aa)
	Q290I4	Vesicle-associated membrane protein 2. (156 aa)
	Q292C2	WAS protein family homolog 1. (491 aa)
	Q294C7	Uncharacterized protein, isoform A. (770 aa)
	Q294Q3	Uncharacterized protein, isoform D. (363 aa)
	Dpse_Pak3	P21-activated kinase 1. (586 aa)
	Q297M9	Uncharacterized protein, isoform B. (85 aa)
	Q298D8	Uncharacterized protein. (320 aa)
	DpseGA16714	Uncharacterized protein, isoform A. (891 aa)
	DpseGA15435	Uncharacterized protein. (515 aa)
	DpseGA19819	Uncharacterized protein. (1971 aa)
	DpseGA16566	Uncharacterized protein. (727 aa)
	DpseGA14608	Uncharacterized protein, isoform A. (1097 aa)
	DpseGA10382	Uncharacterized protein, isoform A. (1913 aa)
	DpseGA13122	Uncharacterized protein. (1496 aa)
	DpseGA16662	Uncharacterized protein. (504 aa)
	arm	Armadillo segment polarity protein; May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis (By similarity). Belongs to the beta-catenin family. (832 aa)
	Cdc42	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity). (191 aa)
	mbt	Non-specific serine/threonine protein kinase. (638 aa)
	DpseGA18539	Uncharacterized protein, isoform C. (1595 aa)
	DpseGA19895	Uncharacterized protein, isoform A. (573 aa)
	DpseGA12812	Uncharacterized protein. (180 aa)
	DpseGA20834	Uncharacterized protein, isoform C. (1380 aa)
	DpseGA12011	Uncharacterized protein, isoform A. (157 aa)

Your Current Organism:

Drosophila pseudoobscura

NCBI taxonomy Id: 46245
Other names: D. pseudoobscura pseudoobscura, Drosophila pseudoobscura pseudoobscura

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R3NHI5	Cdc42	A0A0R3NHI5	Q29HY3	Uncharacterized protein, isoform A.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	0.471
A0A0R3NKH8	A0A0R3NTR6	A0A0R3NKH8	A0A0R3NTR6	Uncharacterized protein, isoform B.	Rho guanine nucleotide exchange factor 12.	0.412
A0A0R3NKH8	Cdc42	A0A0R3NKH8	Q29HY3	Uncharacterized protein, isoform B.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	0.506
A0A0R3NMU4	DpseGA10030	A0A0R3NMU4	A0A0R3NUE9	Uncharacterized protein, isoform A.	Uncharacterized protein, isoform E.	0.555
A0A0R3NMU4	N6WBU9	A0A0R3NMU4	N6WBU9	Uncharacterized protein, isoform A.	Uncharacterized protein.	0.543
A0A0R3NTR6	A0A0R3NKH8	A0A0R3NTR6	A0A0R3NKH8	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform B.	0.412
A0A0R3NTR6	Cdc42	A0A0R3NTR6	Q29HY3	Rho guanine nucleotide exchange factor 12.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity).	0.709
A0A0R3NTR6	DpseGA10030	A0A0R3NTR6	A0A0R3NUE9	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform E.	0.585
A0A0R3NTR6	DpseGA12597	A0A0R3NTR6	A0A0R3P8T5	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein.	0.425
A0A0R3NTR6	DpseGA14608	A0A0R3NTR6	Q29LX2	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform A.	0.448
A0A0R3NTR6	DpseGA16714	A0A0R3NTR6	Q2M1D6	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform A.	0.476
A0A0R3NTR6	DpseGA17694	A0A0R3NTR6	A0A0R3P6T7	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform D.	0.533
A0A0R3NTR6	DpseGA18858	A0A0R3NTR6	A0A0R3P804	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein.	0.593
A0A0R3NTR6	DpseGA20666	A0A0R3NTR6	A0A0R3P0R0	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform B.	0.500
A0A0R3NTR6	DpseGA20834	A0A0R3NTR6	Q29EP3	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform C.	0.666
A0A0R3NTR6	DpseGA22567	A0A0R3NTR6	B5DLR5	Rho guanine nucleotide exchange factor 12.	DH domain-containing protein.	0.601
A0A0R3NTR6	DpseGA22812	A0A0R3NTR6	A0A0R3P3J5	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform B.	0.466
A0A0R3NTR6	DpseGA22873	A0A0R3NTR6	A0A0R3NXM7	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform B.	0.414
A0A0R3NTR6	DpseGA28275	A0A0R3NTR6	B5DRR3	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform C.	0.766
A0A0R3NTR6	DpseGA28748	A0A0R3NTR6	B5DK50	Rho guanine nucleotide exchange factor 12.	Uncharacterized protein, isoform A.	0.977