STRINGSTRING
yidC yidC pilE_1 pilE_1 pilC_1 pilC_1 lspE_1 lspE_1 lspD_1 lspD_1 Lgor_0075 Lgor_0075 Lgor_0076 Lgor_0076 Lgor_0077 Lgor_0077 Lgor_0078 Lgor_0078 Lgor_0081 Lgor_0081 Lgor_0095 Lgor_0095 Lgor_0141 Lgor_0141 ffh ffh secY secY secE secE ftsB ftsB secB secB Lgor_0542 Lgor_0542 Lgor_0543 Lgor_0543 Lgor_0545 Lgor_0545 Lgor_0552 Lgor_0552 Lgor_0868 Lgor_0868 Lgor_0882 Lgor_0882 secG secG Lgor_1026 Lgor_1026 Lgor_1027 Lgor_1027 secA_2 secA_2 ychJ ychJ slt slt pilM pilM pilN pilN pilQ pilQ yajC yajC secD secD secF secF lspE_2 lspE_2 lspD_2 lspD_2 clpB clpB traG traG Lgor_1782 Lgor_1782 Lgor_1783 Lgor_1783 lptC lptC clpA clpA Lgor_1902 Lgor_1902 tolC tolC Lgor_1961 Lgor_1961 Lgor_1963 Lgor_1963 pilE_4 pilE_4 Lgor_1999 Lgor_1999 tatA tatA tatB tatB Lgor_2112 Lgor_2112 tatC tatC ftsY ftsY secA secA Lgor_3117 Lgor_3117 Lgor_3116 Lgor_3116 lssD lssD Lgor_2358 Lgor_2358 pilB pilB pilC_2 pilC_2 pilD pilD traD_2 traD_2 Lgor_2587 Lgor_2587 Lgor_2683 Lgor_2683 lspF lspF lspG lspG lspH lspH lspI lspI lspJ lspJ lspK lspK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yidCCytoplasmic insertase into membrane protein, Sec system; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (557 aa)
pilE_1Tfp pilus assembly protein, major type IV pilin class A. (141 aa)
pilC_1Pilus assembly protein PilC. (411 aa)
lspE_1Type II protein secretion ATPase LspE. (570 aa)
lspD_1Type II protein secretion LspD. (578 aa)
Lgor_0075General secretion pathway, M protein. (244 aa)
Lgor_0076Fimbrial assembly protein (PilN). (215 aa)
Lgor_0077Hypothetical protein. (307 aa)
Lgor_0078Hypothetical protein. (167 aa)
Lgor_0081Hypothetical protein. (135 aa)
Lgor_0095Type II/III secretion system protein. (246 aa)
Lgor_0141Protein IcmO (DotL). (781 aa)
ffhSignal recognition particle protein Ffh; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual comp [...] (459 aa)
secYPreprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (442 aa)
secEPreprotein translocase secE subunit. (148 aa)
ftsBHypothetical protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (89 aa)
secBProtein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (155 aa)
Lgor_0542Hypothetical protein. (1163 aa)
Lgor_0543Hypothetical protein. (219 aa)
Lgor_0545Type VI secretion lipoprotein. (193 aa)
Lgor_0552Phage-related baseplate assembly protein. (815 aa)
Lgor_0868Outer membrane channel protein. (467 aa)
Lgor_0882Hypothetical protein. (958 aa)
secGProtein-export membrane protein secG (preprotein translocase subunit); Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (106 aa)
Lgor_1026General secretion pathway protein L; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (379 aa)
Lgor_1027General secretion pathway protein. (161 aa)
secA_2Coiled-coil protein. (2917 aa)
ychJPutative SEC-C motif domain protein. (159 aa)
sltSoluble lytic murein transglycosylase. (594 aa)
pilMTfp pilus assembly protein, ATPase PilM. (364 aa)
pilNTfp pilus assembly protein PilN. (195 aa)
pilQType IV pilus (Tfp) assembly protein PilQ. (701 aa)
yajCSecYEG protein translocase auxillary subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (111 aa)
secDProtein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (618 aa)
secFProtein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (305 aa)
lspE_2Type II protein secretion ATPase LspE; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (495 aa)
lspD_2Type II protein secretion LspD. (796 aa)
clpBEndopeptidase Clp ATP-binding subunit B; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (858 aa)
traGConjugal transfer protein TraG. (629 aa)
Lgor_1782Hypothetical protein. (246 aa)
Lgor_1783Hypothetical protein. (106 aa)
lptCLipopolysaccharide export system protein LptC. (188 aa)
clpAATP binding protease component ClpA; Belongs to the ClpA/ClpB family. (754 aa)
Lgor_1902General secretion pathway protein C. (167 aa)
tolCOuter membrane protein TolC. (459 aa)
Lgor_1961Hypothetical protein. (312 aa)
Lgor_1963Hypothetical protein. (221 aa)
pilE_4Type IV pilin PilE. (181 aa)
Lgor_1999LigA, interaptin. (2766 aa)
tatATatA protein(twin arginine translocation); Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (61 aa)
tatBTatB protein (twin arginine translocation). (76 aa)
Lgor_2112Outer membrane efflux protein. (590 aa)
tatCSec-independent protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (229 aa)
ftsYHypothetical protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (350 aa)
secAPreprotein translocase, secretion protein SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (896 aa)
Lgor_3117IcmF. (973 aa)
Lgor_3116IcmH (DotU). (262 aa)
lssDSecretion system protein D. (414 aa)
Lgor_2358Hypothetical protein. (325 aa)
pilBPilus assembly protein PilB. (574 aa)
pilC_2Pilus assembly protein PilC. (406 aa)
pilDType 4 prepilin-like proteins leader peptide processing enzyme; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (286 aa)
traD_2Conjugative transfer protein TraD. (617 aa)
Lgor_2587Conjugal transfer mating pair stabilization protein TraN. (603 aa)
Lgor_2683Tfp type 4 fimbrial pilin related signal peptide protein domain protein. (148 aa)
lspFType II secretory pathway protein LspF. (400 aa)
lspGType II secretory pathway protein LspG. (140 aa)
lspHType II secretory pathway protein LspH. (215 aa)
lspIType II secretory pathway protein LspI. (124 aa)
lspJType II secretory pathway protein LspJ. (211 aa)
lspKType II secretory pathway protein LspK. (313 aa)
Your Current Organism:
Fluoribacter gormanii
NCBI taxonomy Id: 464
Other names: ATCC 33297, ATCC 33342, CCUG 12267, CIP 104724, DSM 16641, DSM 25296, F. gormanii, Legionella gormanii, NCTC 11401, strain LS-13
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