STRINGSTRING
AMN46922.1 AMN46922.1 AMN45598.1 AMN45598.1 topA topA AMN45656.1 AMN45656.1 AMN45680.1 AMN45680.1 AMN45760.1 AMN45760.1 fadB fadB icmF icmF AMN45983.1 AMN45983.1 gpmA gpmA AMN45993.1 AMN45993.1 AMN46056.1 AMN46056.1 hemL hemL AMN46128.1 AMN46128.1 AMN46137.1 AMN46137.1 AMN46210.1 AMN46210.1 AMN46264.1 AMN46264.1 AMN46321.1 AMN46321.1 nnrD nnrD AMN46369.1 AMN46369.1 AMN46383.1 AMN46383.1 AMN46392.1 AMN46392.1 AMN46401.1 AMN46401.1 AMN46416.1 AMN46416.1 pgi pgi AMN46445.1 AMN46445.1 tig tig AMN46470.1 AMN46470.1 purE purE AMN46657.1 AMN46657.1 rpiA rpiA AMN46700.1 AMN46700.1 apaG apaG surA surA queA queA glmM glmM tpiA tpiA truB truB AMN46851.1 AMN46851.1 AMN46858.1 AMN46858.1 gyrA gyrA AMN46866.1 AMN46866.1 AMN46950.1 AMN46950.1 hisA hisA AMN46975.1 AMN46975.1 AMN46999.1 AMN46999.1 AMN47051.1 AMN47051.1 AMN47139.1 AMN47139.1 mtnA mtnA AMN47276.1 AMN47276.1 AMN47318.1 AMN47318.1 truD truD AMN47428.1 AMN47428.1 AMN47434.1 AMN47434.1 AMN47438.1 AMN47438.1 AMN47439.1 AMN47439.1 AMN47487.1 AMN47487.1 truA truA parC parC parE parE AMN47584.1 AMN47584.1 AMN47597.1 AMN47597.1 AMN47758.1 AMN47758.1 AMN47780.1 AMN47780.1 AMN47783.1 AMN47783.1 AMN47798.1 AMN47798.1 groEL groEL AMN47897.1 AMN47897.1 AMN47909.1 AMN47909.1 AMN47917.1 AMN47917.1 dapF dapF trpF trpF AMN48394.1 AMN48394.1 gyrB gyrB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AMN46922.1UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (378 aa)
AMN45598.1methylmalonyl-CoA mutase; MDM; functions in conversion of succinate to propionate. (721 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (899 aa)
AMN45656.13-hydroxyacyl-CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (693 aa)
AMN45680.1Maltose alpha-D-glucosyltransferase/ alpha-amylase. (1105 aa)
AMN45760.12-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (255 aa)
fadBMultifunctional fatty acid oxidation complex subunit alpha; 'includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids'. (714 aa)
icmFmethylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1149 aa)
AMN45983.1Hypothetical protein. (306 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa)
AMN45993.1Peptidyl-prolyl cis-trans isomerase A (cyclophilin A); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
AMN46056.1Abortive phage resistance protein. (598 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway. (424 aa)
AMN46128.1Arabinose-5-phosphate isomerase. (332 aa)
AMN46137.1Chorismate mutase / prephenate dehydrogenase. (369 aa)
AMN46210.1enoyl-CoA hydratase. (264 aa)
AMN46264.12-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase. (275 aa)
AMN46321.1Hypothetical protein. (228 aa)
nnrDADP-dependent NAD(P)H-hydrate dehydratase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (555 aa)
AMN46369.13-hydroxyacyl-CoA dehydrogenase. (715 aa)
AMN46383.1Phosphoglucomutase. (550 aa)
AMN46392.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (425 aa)
AMN46401.1Peptidyl-prolyl cis-trans isomerase D. (632 aa)
AMN46416.1UDP-glucuronate 4-epimerase. (334 aa)
pgiGlucose-6-phosphate isomerase; Functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; Belongs to the GPI family. (544 aa)
AMN46445.1Phosphomannomutase. (457 aa)
tigHypothetical protein; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (432 aa)
AMN46470.1UDP-4-amino-4-deoxy-L-arabinose formyltransferase. (354 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa)
AMN46657.1Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (229 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa)
AMN46700.1Pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family. (268 aa)
apaGMagnesium transporter ApaG. (124 aa)
surAPeptidyl-prolyl cis-trans isomerase SurA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (482 aa)
queAS-adenosylmethionine tRNA ribosyltransferase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (368 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (446 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa)
truBHypothetical protein; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (335 aa)
AMN46851.1Peptidyl-prolyl cis-trans isomerase C. (257 aa)
AMN46858.123S rRNA pseudouridine2605 synthase. (365 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (866 aa)
AMN46866.1Prephenate dehydratase. (358 aa)
AMN46950.1UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (371 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (252 aa)
AMN46975.1Maleate isomerase. (248 aa)
AMN46999.13-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase. (681 aa)
AMN47051.1Pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family. (223 aa)
AMN47139.1Hypothetical protein. (195 aa)
mtnAMethylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (370 aa)
AMN47276.123S rRNA pseudouridine955/2504/2580 synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (319 aa)
AMN47318.1Hypothetical protein. (353 aa)
truDtRNA pseudouridine13 synthase; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (378 aa)
AMN47428.1UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (331 aa)
AMN47434.1Glutamate-1-semialdehyde 2,1-aminomutase; Catalyzes the formation of 5-aminovulinate from (S)-4-amino-5-oxopentanoate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa)
AMN47438.1dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (197 aa)
AMN47439.1NAD-dependent dehydratase. (343 aa)
AMN47487.1Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (199 aa)
truAtRNA pseudouridine38-40 synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (265 aa)
parCDNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (734 aa)
parEDNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (630 aa)
AMN47584.13-hydroxydecanoyl-ACP dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (196 aa)
AMN47597.1Peptidyl-prolyl cis-trans isomerase C. (279 aa)
AMN47758.1enoyl-CoA hydratase. (264 aa)
AMN47780.1Copper ABC transporter substrate-binding protein. (419 aa)
AMN47783.1NosL. (174 aa)
AMN47798.123S rRNA pseudouridine1911/1915/1917 synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (321 aa)
groELMolecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (551 aa)
AMN47897.1Hypothetical protein; Belongs to the pseudouridine synthase RsuA family. (331 aa)
AMN47909.116S rRNA pseudouridine516 synthase; Belongs to the pseudouridine synthase RsuA family. (238 aa)
AMN47917.12-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (305 aa)
trpFPhosphoribosylanthranilate isomerase; Belongs to the TrpF family. (214 aa)
AMN48394.1Peptidylprolyl isomerase. (160 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (804 aa)
Your Current Organism:
Steroidobacter denitrificans
NCBI taxonomy Id: 465721
Other names: DSM 18526, JCM 14622, S. denitrificans, Steroidobacter denitrificans Fahrbach et al. 2008, gamma proteobacterium FS-2007, strain FS
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.