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polI polI galU galU SGO_0220 SGO_0220 dinB dinB pnpA pnpA rpoE rpoE nadD nadD rpoZ rpoZ SGO_0647 SGO_0647 coaD coaD thiI thiI dacA dacA dnaX dnaX SGO_0926 SGO_0926 galT galT SGO_0935 SGO_0935 SGO_0994 SGO_0994 rfbA-1 rfbA-1 ribF ribF pcnA pcnA lplA lplA SGO_1241 SGO_1241 dnaG dnaG dnaE dnaE dinG dinG glmU glmU SGO_1538 SGO_1538 glgD glgD glgC glgC SGO_1600 SGO_1600 SGO_1820 SGO_1820 polC polC cdsA cdsA rpoC rpoC rpoB rpoB rpoA rpoA nadR nadR tarI tarI dnaN dnaN SGO_0026 SGO_0026
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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polIDNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (880 aa)
galUUTP-glucose-1-phosphate uridylyltransferase; Identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099. (302 aa)
SGO_0220Protein of unknown function (DUF1447) superfamily; Identified by match to protein family HMM PF07288; Belongs to the UPF0356 family. (76 aa)
dinBDNA-damage-inducible protein P; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (354 aa)
pnpAPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (728 aa)
rpoEDNA-directed RNA polymerase delta chain; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (195 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (210 aa)
rpoZDNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (103 aa)
SGO_0647Identified by match to protein family HMM PF00817; Belongs to the DNA polymerase type-Y family. (471 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa)
thiIThiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (404 aa)
dacAConserved hypothetical protein TIGR00159; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria; Belongs to the adenylate cyclase family. DacA/CdaA subfamily. (260 aa)
dnaXDNA-directed DNA polymerase III; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (556 aa)
SGO_0926Putative DNA replicative RepB-like protein; Identified by match to protein family HMM PF06430. (132 aa)
galTGalactose-1-phosphate uridylyltransferase; Identified by match to protein family HMM PF01087; match to protein family HMM PF02744; match to protein family HMM TIGR01239. (493 aa)
SGO_0935CDP-diglyceride synthetase; Identified by match to protein family HMM PF01864. (196 aa)
SGO_0994Conserved hypothetical protein. (207 aa)
rfbA-1Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (289 aa)
ribFRiboflavin biosynthesis protein RibF; Identified by match to protein family HMM PF01687; match to protein family HMM PF06574; match to protein family HMM TIGR00083; Belongs to the ribF family. (305 aa)
pcnAPolynucleotide adenylyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (399 aa)
lplAIdentified by match to protein family HMM PF03099; match to protein family HMM TIGR00545. (329 aa)
SGO_1241Aminoglycoside adenylyltransferase; Identified by match to protein family HMM PF04439. (277 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (593 aa)
dnaEDNA-directed DNA polymerase III alpha chain; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. (1033 aa)
dinGDnaQ family exonuclease/DinG family helicase, putative; 3'-5' exonuclease. (824 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (459 aa)
SGO_1538DNA-directed DNA polymerase III, delta'' chain. (299 aa)
glgDGlucose-1-phosphate adenylyltransferase, GlgD subunit; Identified by match to protein family HMM TIGR02092. (398 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (380 aa)
SGO_1600DNA polymerase III, delta chain; Identified by match to protein family HMM PF06144; match to protein family HMM TIGR01128. (345 aa)
SGO_1820Conserved hypothetical protein. (265 aa)
polCDNA polymerase III, alpha subunit, Gram-positive type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1462 aa)
cdsAPhosphatidate cytidylyltransferase; Identified by match to protein family HMM PF01148; Belongs to the CDS family. (267 aa)
rpoCDNA-directed RNA polymerase, beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1215 aa)
rpoBDNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1188 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (312 aa)
nadRTranscription regulator; Identified by match to protein family HMM TIGR00125. (352 aa)
tarINucleotidyl transferase, putative; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (240 aa)
dnaNDNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (378 aa)
SGO_0026DHH subfamily 1 protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. (659 aa)
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
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