STRINGSTRING
rplA rplA recR recR gyrB gyrB EzrA EzrA SGO_1420 SGO_1420 SGO_1393 SGO_1393 sufB-2 sufB-2 rplS rplS pheA pheA SGO_1361 SGO_1361 SGO_1348 SGO_1348 SGO_1337 SGO_1337 cysD cysD rpsP rpsP hemH hemH rpsU rpsU dnaG dnaG cobB cobB parE parE rpsA rpsA SGO_1229 SGO_1229 SGO_1225 SGO_1225 fhs-1 fhs-1 SGO_1202 SGO_1202 topA topA SGO_1195 SGO_1195 BL5 BL5 rplL rplL ccdA1 ccdA1 ccdA2 ccdA2 SGO_1135 SGO_1135 acoA acoA SGO_1132 SGO_1132 SGO_1105 SGO_1105 rpsT rpsT ribF ribF rplT rplT rpmI rpmI SGO_1003 SGO_1003 SGO_0996 SGO_0996 rnz rnz SGO_0981 SGO_0981 cutC cutC SGO_0953 SGO_0953 udk udk deaD deaD SGO_0935 SGO_0935 SGO_0930 SGO_0930 leuA leuA SGO_0886 SGO_0886 SGO_0849 SGO_0849 rpmE rpmE SGO_0844 SGO_0844 SGO_0839 SGO_0839 rpmA rpmA rplU rplU SGO_0816 SGO_0816 SGO_0814 SGO_0814 smc smc vicX vicX SGO_0750 SGO_0750 SGO_0724 SGO_0724 SGO_0721 SGO_0721 dgkA dgkA ybeY ybeY hup hup recN recN SGO_0695 SGO_0695 SGO_0679 SGO_0679 SGO_0640 SGO_0640 hpf hpf SGO_0605 SGO_0605 priA priA cshB-2 cshB-2 SGO_0556 SGO_0556 SGO_0545 SGO_0545 SGO_0517 SGO_0517 SGO_0516 SGO_0516 SGO_0513 SGO_0513 dnaI dnaI SGO_0509 SGO_0509 SGO_0505 SGO_0505 SGO_0481 SGO_0481 ILL5 ILL5 nadD nadD SGO_0445 SGO_0445 truA truA SGO_0388 SGO_0388 SGO_0363 SGO_0363 rpsI rpsI rplM rplM mrnC mrnC trx-2 trx-2 rpsO rpsO SGO_0281 SGO_0281 SGO_0273 SGO_0273 trx-1 trx-1 SGO_0262 SGO_0262 SGO_0244 SGO_0244 SGO_0243 SGO_0243 fni fni SGO_0232 SGO_0232 SGO_0216 SGO_0216 rpsG rpsG rpsL rpsL SGO_0191 SGO_0191 rnmV rnmV rpmH rpmH SGO_0172 SGO_0172 abpB abpB SGO_0161 SGO_0161 SGO_0159 SGO_0159 fucA1 fucA1 SGO_0144 SGO_0144 atpB-2 atpB-2 SGO_0133 SGO_0133 SGO_0132 SGO_0132 SGO_0089 SGO_0089 SGO_0043 SGO_0043 purF purF recO recO dnaC dnaC recF recF guaB guaB spo0J spo0J ychF ychF rpsD rpsD purD purD SGO_2069 SGO_2069 rpmG rpmG rpmF rpmF SGO_2041 SGO_2041 SGO_2022 SGO_2022 SGO_2016 SGO_2016 rpsB rpsB SGO_1993 SGO_1993 rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC BS16 BS16 rplN rplN rplX rplX BL6 BL6 rpsN rpsN rpsH rpsH BL10 BL10 rplR rplR rpsE rpsE rpmD rpmD rplO rplO adk adk rpmJ rpmJ rpsM rpsM rpsK rpsK rplQ rplQ SGO_1957 SGO_1957 tyrS tyrS ackA ackA SGO_1900 SGO_1900 rpsF rpsF rpsR rpsR SGO_1857 SGO_1857 SGO_1828 SGO_1828 dtd dtd SGO_1814 SGO_1814 hutG hutG fhs-2 fhs-2 SGO_1807 SGO_1807 ftcD ftcD gldA gldA SGO_1785 SGO_1785 SGO_1772 SGO_1772 SGO_1769 SGO_1769 SGO_1768 SGO_1768 SGO_1744 SGO_1744 rpmB rpmB sufC sufC sufD sufD sufB-1 sufB-1 SGO_1692 SGO_1692 SGO_1684 SGO_1684 lysA lysA SGO_1662 SGO_1662 SGO_1653 SGO_1653 SGO_1634 SGO_1634 SGO_1621 SGO_1621 SGO_1619 SGO_1619 cshA-2 cshA-2 SGO_1605 SGO_1605 argC argC argB argB ogt ogt nth nth SGO_1504 SGO_1504 aha1 aha1 rplK rplK
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (649 aa)
EzrASeptation ring formation regulator ezrA; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (574 aa)
SGO_1420ATP-binding cassette transporter-like protein. (417 aa)
SGO_1393Acetyltransferase, GNAT family; Identified by match to protein family HMM PF00583. (140 aa)
sufB-2FeS assembly protein SufB; Identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980. (460 aa)
rplSRibosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (115 aa)
pheAPrephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01842. (275 aa)
SGO_1361ADP-ribosylhydrolase; Identified by match to protein family HMM PF03747. (284 aa)
SGO_1348Hypothetical cytosolic protein; Identified by match to protein family HMM PF08020. (180 aa)
SGO_1337Identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. (395 aa)
cysDO-acetylhomoserine (thiol)-lyase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326. (426 aa)
rpsPRibosomal protein S16; Identified by match to protein family HMM PF00886; match to protein family HMM TIGR00002; Belongs to the bacterial ribosomal protein bS16 family. (90 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (364 aa)
rpsURibosomal protein S21; Identified by match to protein family HMM PF01165; match to protein family HMM TIGR00030; Belongs to the bacterial ribosomal protein bS21 family. (58 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (593 aa)
cobBNAD-dependent deacetylase (Regulatory protein SIR2-like protein); NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (243 aa)
parEDNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (649 aa)
rpsA30S ribosomal protein S1; Identified by match to protein family HMM PF00575. (401 aa)
SGO_1229DNA repair protein; Identified by match to protein family HMM PF04002; match to protein family HMM TIGR00608; Belongs to the UPF0758 family. (226 aa)
SGO_1225Pyridoxal-phosphate dependent aminotransferase; Identified by match to protein family HMM PF00266. (375 aa)
fhs-1Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
SGO_1202GTP-binding protein; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (283 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (697 aa)
SGO_1195Conserved hypothetical protein. (235 aa)
BL550S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (166 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa)
ccdA1Cytochrome c-type biogenesis protein; Identified by match to protein family HMM PF02683. (236 aa)
ccdA2Cytochrome c-type biogenesis protein; Identified by match to protein family HMM PF02683. (236 aa)
SGO_1135Putative esterase superfamily; Identified by match to protein family HMM PF00756. (246 aa)
acoAAcetoin dehydrogenase; Identified by match to protein family HMM PF00676. (322 aa)
SGO_1132Acetoin dehydrogenase; Identified by match to protein family HMM PF02779; match to protein family HMM PF02780. (330 aa)
SGO_1105Leucine-rich repeat containing protein. (96 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (80 aa)
ribFRiboflavin biosynthesis protein RibF; Identified by match to protein family HMM PF01687; match to protein family HMM PF06574; match to protein family HMM TIGR00083; Belongs to the ribF family. (305 aa)
rplTRibosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa)
rpmIRibosomal protein L35; Identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
SGO_1003DNA replication protein DnaD; Identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446. (226 aa)
SGO_0996Oxidoreductase, short-chain dehydrogenase/reductase family; Identified by match to protein family HMM PF00106; match to protein family HMM PF08659; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (251 aa)
rnzMetallo-beta-lactamase superfamily protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (309 aa)
SGO_0981comE operon protein 2 family; Identified by match to protein family HMM PF00383. (155 aa)
cutCCopper homeostasis protein CutC; Participates in the control of copper homeostasis. Belongs to the CutC family. (210 aa)
SGO_0953Endoribonuclease L-PSP, putative; Identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004. (126 aa)
udkUridine kinase; Identified by match to protein family HMM PF00485; match to protein family HMM TIGR00235. (210 aa)
deaDDEAD RNA helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271. (371 aa)
SGO_0935CDP-diglyceride synthetase; Identified by match to protein family HMM PF01864. (196 aa)
SGO_0930Cation efflux system protein; Identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297. (296 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (522 aa)
SGO_0886Identified by match to protein family HMM PF08245; match to protein family HMM PF08353. (447 aa)
SGO_0849Identified by match to protein family HMM PF01368; match to protein family HMM PF02272. (314 aa)
rpmERibosomal protein L31; Identified by match to protein family HMM PF01197; match to protein family HMM TIGR00105. (94 aa)
SGO_0844Conserved hypothetical protein. (96 aa)
SGO_0839TfoX N-terminal domain superfamily; Identified by match to protein family HMM PF04993. (107 aa)
rpmARibosomal protein L27; Identified by match to protein family HMM PF01016; match to protein family HMM TIGR00062; Belongs to the bacterial ribosomal protein bL27 family. (97 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (104 aa)
SGO_0816Conserved hypothetical protein. (173 aa)
SGO_0814Aminotransferase, class-V; Identified by match to protein family HMM PF00266. (380 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1177 aa)
vicXZn-dependent hydrolase (beta-lactamase superfamily); Identified by match to protein family HMM PF00753. (267 aa)
SGO_0750Efflux transporter, RND family, MFP subunit subfamily; Identified by match to protein family HMM TIGR01730. (394 aa)
SGO_0724Dipeptidase; Identified by match to protein family HMM PF03577. (541 aa)
SGO_0721abpB-like dipeptidase lipoprotein; Identified by match to protein family HMM PF03577. (576 aa)
dgkADiacylglycerol kinase (DAGK) (Diglyceride kinase)(DGK); Identified by match to protein family HMM PF01219. (132 aa)
ybeYConserved hypothetical protein TIGR00043; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (165 aa)
hupDNA-binding histone-like protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (91 aa)
recNDNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (552 aa)
SGO_0695Geranyltranstransferase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. (291 aa)
SGO_0679S4 domain; Identified by match to protein family HMM PF01479. (275 aa)
SGO_0640Modification methylase. (419 aa)
hpfRibosomal subunit interface protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (180 aa)
SGO_0605General stress protein GSP13; Identified by match to protein family HMM PF00575. (128 aa)
priAPrimosomal protein N'; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (793 aa)
cshB-2ATP-dependent RNA helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (447 aa)
SGO_0556DNA helicase-like protein, putative; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271. (826 aa)
SGO_0545Identified by match to protein family HMM PF01248. (99 aa)
SGO_0517Acetyltransferase, GNAT family; Identified by match to protein family HMM PF00583. (166 aa)
SGO_0516Acetyltransferase, GNAT family; Identified by match to protein family HMM PF00583. (169 aa)
SGO_0513Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434; match to protein family HMM PF08455. (1029 aa)
dnaIPrimosomal protein DnaI; Identified by match to protein family HMM PF07319. (299 aa)
SGO_0509Replication initiation and membrane attachment protein (DnaB) superfamily; Identified by match to protein family HMM PF07261. (384 aa)
SGO_0505PTS system, IIBC component; Identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR02003. (730 aa)
SGO_0481Conserved hypothetical protein. (119 aa)
ILL5Amino acid aminohydrolase; Identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891. (377 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (210 aa)
SGO_0445Identified by match to protein family HMM PF01926. (368 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (249 aa)
SGO_0388LPXTG cell wall surface protein, zinc carboxypeptidase family; Identified by match to protein family HMM PF00746; match to protein family HMM TIGR01167. (1085 aa)
SGO_0363Gp49 bacteriophage-like protein; Identified by match to protein family HMM TIGR01714. (279 aa)
rpsIRibosomal protein S9; Identified by match to protein family HMM PF00380; Belongs to the universal ribosomal protein uS9 family. (130 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (148 aa)
mrnCcysteinyl-tRNA synthetase; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (134 aa)
trx-2Thioredoxin; Identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; Belongs to the thioredoxin family. (104 aa)
rpsORibosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa)
SGO_0281PTS system, beta-glucoside-specific IIABC component; Identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00830; match to protein family HMM TIGR01995. (629 aa)
SGO_0273Zinc-binding oxidoreductase; Identified by match to protein family HMM PF08240. (334 aa)
trx-1Thioredoxin; Identified by match to protein family HMM PF00085; match to protein family HMM PF08534; match to protein family HMM TIGR01068; Belongs to the thioredoxin family. (104 aa)
SGO_0262Dipeptidase; Identified by match to protein family HMM PF03577. (472 aa)
SGO_0244hydroxymethylglutaryl-CoA synthase; Identified by match to protein family HMM PF01154; match to protein family HMM PF08540; match to protein family HMM TIGR01835. (392 aa)
SGO_0243hydroxymethylglutaryl-CoA reductase, degradative; Identified by match to protein family HMM TIGR00532; Belongs to the HMG-CoA reductase family. (424 aa)
fniFMN-dependent dehydrogenase family protein; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (334 aa)
SGO_0232Conserved hypothetical protein TIGR00103; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (119 aa)
SGO_0216Histone acetyltransferase HPA2; Identified by match to protein family HMM PF00583. (134 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsLRibosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (137 aa)
SGO_0191Hypothetical protein; Identified by Glimmer2; putative. (471 aa)
rnmVPrimase-related protein; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. (196 aa)
rpmHRibosomal protein L34; Identified by match to protein family HMM PF00468; match to protein family HMM TIGR01030; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
SGO_0172Conserved hypothetical protein TIGR00266; Identified by match to protein family HMM PF01987; match to protein family HMM TIGR00266. (236 aa)
abpBIdentified by match to protein family HMM PF03577. (652 aa)
SGO_0161Conserved hypothetical protein; Identified by match to protein family HMM PF01694. (227 aa)
SGO_0159Hippurate hydrolase; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (377 aa)
fucA1alpha-L-fucosidase; Identified by match to protein family HMM PF01120. (488 aa)
SGO_0144Conserved hypothetical protein. (1192 aa)
atpB-2V-type sodium ATP synthase, chain B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (464 aa)
SGO_0133ATP synthase (F/14-kDa) subunit; Identified by match to protein family HMM PF01990. (106 aa)
SGO_0132ATP synthase (C/AC39) subunit; Identified by match to protein family HMM PF01992. (337 aa)
SGO_0089Cation efflux system protein; Identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297. (284 aa)
SGO_0043Beta-galactosidase; Identified by match to protein family HMM PF01301; match to protein family HMM PF02449; Belongs to the glycosyl hydrolase 35 family. (592 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (480 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (260 aa)
dnaCReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (451 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (361 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa)
spo0JChromosome segregation protein; Identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; Belongs to the ParB family. (254 aa)
ychFGTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (371 aa)
rpsDRibosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (203 aa)
purDPhosphoribosylamine--glycine ligase; Identified by match to protein family HMM PF01071; match to protein family HMM PF02655; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM PF08442; match to protein family HMM TIGR00877; Belongs to the GARS family. (419 aa)
SGO_2069ATP-binding protein of ABC transporter; Identified by match to protein family HMM PF00005. (328 aa)
rpmGRibosomal protein L33; Identified by match to protein family HMM PF00471; match to protein family HMM TIGR01023; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
rpmFRibosomal protein L32; Identified by match to protein family HMM PF01783; match to protein family HMM TIGR01031; Belongs to the bacterial ribosomal protein bL32 family. (60 aa)
SGO_2041Conserved hypothetical protein TIGR00250; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (139 aa)
SGO_2022UDP-glucose 4-epimerase BH3715; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993. (288 aa)
SGO_2016Nucleotide sugar dehydratase, putative; Identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993. (363 aa)
rpsBRibosomal protein S2; Identified by match to protein family HMM PF00318; match to protein family HMM TIGR01011; Belongs to the universal ribosomal protein uS2 family. (260 aa)
SGO_1993Possible transcriptional regulator; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (317 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rplCRibosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (208 aa)
rplDRibosomal protein L4/L1 family; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (207 aa)
rplWRibosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (98 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplVRibosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (114 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (217 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (137 aa)
rpmCRibosomal protein L29; Identified by match to protein family HMM PF00831; match to protein family HMM TIGR00012; Belongs to the universal ribosomal protein uL29 family. (68 aa)
BS1630S ribosomal protein; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (86 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplXRibosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (101 aa)
BL650S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rpsNRibosomal protein S14p/S29e; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
BL1050S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa)
rpsERibosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (164 aa)
rpmD50S ribosomal protein L30 -related protein; Identified by match to protein family HMM PF00327; match to protein family HMM TIGR01308. (74 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
adkAdenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa)
rpmJRibosomal protein L36; Identified by match to protein family HMM PF00444; match to protein family HMM TIGR01022; Belongs to the bacterial ribosomal protein bL36 family. (38 aa)
rpsMRibosomal protein S13p/S18e; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa)
rpsKRibosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (127 aa)
rplQRibosomal protein L17; Identified by match to protein family HMM PF01196; match to protein family HMM TIGR00059. (128 aa)
SGO_1957Conserved hypothetical protein. (426 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (418 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa)
SGO_1900Identified by match to protein family HMM PF00085. (105 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (96 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (79 aa)
SGO_1857PTS system, IIABC components; Identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01996. (636 aa)
SGO_1828ATPase, AAA family; Identified by match to protein family HMM PF00004. (422 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (151 aa)
SGO_1814Putative regulatory protein; Identified by match to protein family HMM PF03704; match to protein family HMM PF07719. (1013 aa)
hutGFormimidoylglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family. (329 aa)
fhs-2Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. (557 aa)
SGO_1807Serine cycle enzyme, putative; Identified by match to protein family HMM PF04961. (208 aa)
ftcDGlutamate formiminotransferase; Identified by match to protein family HMM PF02971; match to protein family HMM PF07837; match to protein family HMM TIGR02024. (299 aa)
gldAGlycerol dehydrogenase NAD+ dependent; Identified by match to protein family HMM PF00465. (364 aa)
SGO_1785Nickel-cobalt-cadmium resistance protein; Identified by match to protein family HMM PF04140. (187 aa)
SGO_1772Integral membrane protein; Identified by match to protein family HMM PF01988. (229 aa)
SGO_1769Protein of unknown function (DUF1237) superfamily; Identified by match to protein family HMM PF06824. (429 aa)
SGO_1768Glycosyl hydrolase, family 38; Identified by match to protein family HMM PF01074; match to protein family HMM PF07748. (877 aa)
SGO_1744ABC transporter, ATP-binding protein SP0636; Identified by match to protein family HMM PF00005. (330 aa)
rpmBRibosomal protein L28; Identified by match to protein family HMM PF00830; match to protein family HMM TIGR00009; Belongs to the bacterial ribosomal protein bL28 family. (62 aa)
sufCFeS assembly ATPase SufC; Identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978. (256 aa)
sufDFeS assembly protein SufD; Identified by match to protein family HMM PF01458; match to protein family HMM TIGR01981. (420 aa)
sufB-1FeS assembly protein SufB; Identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980. (470 aa)
SGO_16923-oxoacyl-[acyl-carrier-protein] synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (410 aa)
SGO_1684acyl-CoA dehydrogenase family. (354 aa)
lysADiaminopimelate decarboxylase; Identified by match to protein family HMM PF00278; match to protein family HMM PF02784. (416 aa)
SGO_1662Putative methylated-DNA methyltransferase; Identified by match to protein family HMM PF01035. (102 aa)
SGO_1653Trehalose PTS enzyme II; Identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01992. (669 aa)
SGO_1634Magnesium-translocating P-type ATPase; Identified by match to protein family HMM PF00122; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01524. (886 aa)
SGO_1621HD domain protein; Identified by match to protein family HMM PF01966. (433 aa)
SGO_1619Cation-transporting ATPase, E1-E2 family; Identified by match to protein family HMM PF00122; match to protein family HMM PF00689; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494. (898 aa)
cshA-2ATP-dependent RNA helicase, DEAD/DEAH box family; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (523 aa)
SGO_1605P-type ATPase, metal cation transport; Identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494. (789 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (340 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (245 aa)
ogtmethylated-DNA-[protein]-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (165 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (209 aa)
SGO_1504Histidine kinase; Identified by match to protein family HMM PF02518. (326 aa)
aha1Cation-transporting ATPase yfgQ; Identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494. (780 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
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