(78 nodes) Regulation of protein catabolic process network (Fasciola gigantica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGIG_03693	Proteasome (Prosome macropain) 26S subunit ATPase 3; Belongs to the AAA ATPase family. (422 aa)
	FGIG_11754	26S proteasome non-ATPase regulatory subunit 10. (412 aa)
	FGIG_02761	Rhomboid domain-containing protein 1. (262 aa)
	FGIG_12345	26S protease regulatory subunit 7. (132 aa)
	FGIG_10243	Uncharacterized protein. (216 aa)
	FGIG_09346	RBR-type E3 ubiquitin transferase. (432 aa)
	FGIG_12343	Delta-aminolevulinic acid dehydratase. (233 aa)
	FGIG_06753	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (974 aa)
	FGIG_05072	26S protease regulatory subunit 7. (118 aa)
	FGIG_02725	TATA element modulatory factor. (958 aa)
	FGIG_04819	Uncharacterized protein. (142 aa)
	FGIG_02925	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (1230 aa)
	FGIG_04527	Proteasome 26S subunit subunit 4 ATPase; Belongs to the AAA ATPase family. (436 aa)
	FGIG_12559	Uncharacterized protein. (170 aa)
	FGIG_10242	Metalloproteinase inhibitor 1. (118 aa)
	FGIG_06061	Uncharacterized protein. (224 aa)
	FGIG_04055	Bardet-Biedl syndrome 7 protein. (748 aa)
	FGIG_01304	Ubiquitin carboxyl-terminal hydrolase. (529 aa)
	FGIG_03282	Ubiquitin-like domain-containing protein. (1332 aa)
	FGIG_01053	RGS domain-containing protein. (840 aa)
	FGIG_07571	Putative Axis inhibition protein axin. (824 aa)
	FGIG_05537	Uncharacterized protein. (592 aa)
	FGIG_03844	Mitotic spindle assembly checkpoint protein MAD2. (224 aa)
	FGIG_00980	Ubiquitin carboxyl-terminal hydrolase. (324 aa)
	FGIG_11853	Putative vacuolar sorting protein. (211 aa)
	FGIG_05474	RBR-type E3 ubiquitin transferase. (477 aa)
	FGIG_07070	26S protease regulatory subunit 7. (171 aa)
	FGIG_08349	CMGC/GSK protein kinase. (390 aa)
	FGIG_11655	Uncharacterized protein. (403 aa)
	FGIG_08670	Casein kinase I delta. (611 aa)
	FGIG_02559	26S protease regulatory subunit 7. (76 aa)
	FGIG_00399	Uncharacterized protein. (393 aa)
	FGIG_05067	Putative sorbin. (882 aa)
	FGIG_01174	26S protease regulatory subunit 7. (96 aa)
	FGIG_06060	Uncharacterized protein. (168 aa)
	FGIG_11993	Uncharacterized protein. (242 aa)
	FGIG_10215	Fizzy protein. (667 aa)
	FGIG_08946	NEFA-interacting nuclear protein NIP30. (248 aa)
	FGIG_12146	Tetraspanning orphan receptor. (310 aa)
	FGIG_02557	Proteasome (Prosome macropain) 26S subunit ATPase 5; Belongs to the AAA ATPase family. (430 aa)
	FGIG_06731	Vacuolar protein sorting-associated protein 35. (839 aa)
	FGIG_04767	Putative cyclin protein. (1343 aa)
	FGIG_11138	Uncharacterized protein. (204 aa)
	FGIG_07389	Putative Glycogen synthase kinase. (207 aa)
	FGIG_11082	Uncharacterized protein. (124 aa)
	FGIG_10414	Protein kinase. (405 aa)
	FGIG_07669	UBX domain-containing protein 1-A. (301 aa)
	FGIG_02569	ADP-ribosylation factor-binding protein GGA2. (170 aa)
	FGIG_06088	Uncharacterized protein. (549 aa)
	FGIG_10086	Adenomatous polyposis coli protein 2. (1794 aa)
	FGIG_07332	Dyslexia susceptibility 1 candidate protein. (322 aa)
	FGIG_07690	RBR-type E3 ubiquitin transferase. (550 aa)
	FGIG_12522	26S protease regulatory subunit 10B. (117 aa)
	FGIG_05147	RBR-type E3 ubiquitin transferase. (404 aa)
	FGIG_06716	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (125 aa)
	FGIG_02537	Uncharacterized protein. (261 aa)
	FGIG_02092	26S proteasome non-ATPase regulatory subunit 3. (236 aa)
	FGIG_11017	DNA damage-binding protein 1. (1400 aa)
	FGIG_07275	Proteasome activator complex subunit 3. (228 aa)
	FGIG_07192	Uncharacterized protein. (2322 aa)
	FGIG_01963	Putative atp-dependent 26s proteasome regulatory subunit posttranslational modification. (290 aa)
	FGIG_05093	Glycogen synthase kinase. (347 aa)
	FGIG_11721	RING-type domain-containing protein. (215 aa)
	FGIG_07741	Uncharacterized protein. (703 aa)
	FGIG_08057	Proteasome (Prosome macropain) 26S subunit ATPase 4; Belongs to the AAA ATPase family. (415 aa)
	FGIG_12179	ADP-ribosylation factor-binding protein GGA. (250 aa)
	FGIG_08424	Cell division cycle 20 cofactor of APC complex. (447 aa)
	FGIG_06318	Ubiquitin carboxyl-terminal hydrolase. (925 aa)
	FGIG_10174	PDZ domain-containing protein GIPC1. (129 aa)
	FGIG_10998	Proteasome (Prosome macropain) 26S subunit ATPase 6. (371 aa)
	FGIG_04327	26S proteasome non-ATPase regulatory subunit 3. (477 aa)
	FGIG_09252	Proteasome inhibitor PI31 subunit. (237 aa)
	FGIG_11151	Peptidyl-prolyl cis-trans isomerase. (197 aa)
	FGIG_00993	Ric1-domain-containing protein. (1207 aa)
	FGIG_10017	Proteasome activator complex subunit 3. (273 aa)
	FGIG_01419	RBR-type E3 ubiquitin transferase. (545 aa)
	FGIG_04858	Transmembrane protein. (419 aa)
	FGIG_11735	Fizzy protein. (468 aa)

Your Current Organism:

Fasciola gigantica

NCBI taxonomy Id: 46835
Other names: F. gigantica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGIG_00980	FGIG_01174	A0A504YX92	A0A504YS76	Ubiquitin carboxyl-terminal hydrolase.	26S protease regulatory subunit 7.	0.824
FGIG_00980	FGIG_01304	A0A504YX92	A0A504Z097	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase.	0.972
FGIG_00980	FGIG_01963	A0A504YX92	A0A504YFK4	Ubiquitin carboxyl-terminal hydrolase.	Putative atp-dependent 26s proteasome regulatory subunit posttranslational modification.	0.824
FGIG_00980	FGIG_02092	A0A504YX92	A0A504YHK3	Ubiquitin carboxyl-terminal hydrolase.	26S proteasome non-ATPase regulatory subunit 3.	0.965
FGIG_00980	FGIG_02557	A0A504YX92	A0A504YPG9	Ubiquitin carboxyl-terminal hydrolase.	Proteasome (Prosome macropain) 26S subunit ATPase 5; Belongs to the AAA ATPase family.	0.979
FGIG_00980	FGIG_02559	A0A504YX92	A0A504YSS5	Ubiquitin carboxyl-terminal hydrolase.	26S protease regulatory subunit 7.	0.824
FGIG_00980	FGIG_02925	A0A504YX92	A0A504Z300	Ubiquitin carboxyl-terminal hydrolase.	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.	0.965
FGIG_00980	FGIG_03693	A0A504YX92	A0A504YV76	Ubiquitin carboxyl-terminal hydrolase.	Proteasome (Prosome macropain) 26S subunit ATPase 3; Belongs to the AAA ATPase family.	0.976
FGIG_00980	FGIG_04327	A0A504YX92	A0A504YBM6	Ubiquitin carboxyl-terminal hydrolase.	26S proteasome non-ATPase regulatory subunit 3.	0.965
FGIG_00980	FGIG_04527	A0A504YX92	A0A504Z1X5	Ubiquitin carboxyl-terminal hydrolase.	Proteasome 26S subunit subunit 4 ATPase; Belongs to the AAA ATPase family.	0.978
FGIG_00980	FGIG_04819	A0A504YX92	A0A504Z3K6	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein.	0.824
FGIG_00980	FGIG_05072	A0A504YX92	A0A504Z4P0	Ubiquitin carboxyl-terminal hydrolase.	26S protease regulatory subunit 7.	0.824
FGIG_00980	FGIG_06318	A0A504YX92	A0A504YC83	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase.	0.513
FGIG_00980	FGIG_06753	A0A504YX92	A0A504Z569	Ubiquitin carboxyl-terminal hydrolase.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.976
FGIG_00980	FGIG_07070	A0A504YX92	A0A504YWH5	Ubiquitin carboxyl-terminal hydrolase.	26S protease regulatory subunit 7.	0.824
FGIG_00980	FGIG_07275	A0A504YX92	A0A504YGH7	Ubiquitin carboxyl-terminal hydrolase.	Proteasome activator complex subunit 3.	0.642
FGIG_00980	FGIG_07669	A0A504YX92	A0A504YJV2	Ubiquitin carboxyl-terminal hydrolase.	UBX domain-containing protein 1-A.	0.538
FGIG_00980	FGIG_08057	A0A504YX92	A0A504YCY0	Ubiquitin carboxyl-terminal hydrolase.	Proteasome (Prosome macropain) 26S subunit ATPase 4; Belongs to the AAA ATPase family.	0.983
FGIG_00980	FGIG_09252	A0A504YX92	A0A504YBE8	Ubiquitin carboxyl-terminal hydrolase.	Proteasome inhibitor PI31 subunit.	0.722
FGIG_00980	FGIG_10017	A0A504YX92	A0A504YAK2	Ubiquitin carboxyl-terminal hydrolase.	Proteasome activator complex subunit 3.	0.661