(18 nodes) TCR signaling network (Fasciola gigantica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGIG_06018	P21-activated kinase 1. (659 aa)
	FGIG_04727	Proteasome subunit beta. (267 aa)
	FGIG_04163	Proteasome subunit beta. (293 aa)
	FGIG_08197	Non-specific serine/threonine protein kinase. (1122 aa)
	FGIG_03693	Proteasome (Prosome macropain) 26S subunit ATPase 3; Belongs to the AAA ATPase family. (422 aa)
	FGIG_03983	26S proteasome non-ATPase regulatory subunit. (375 aa)
	FGIG_06776	F-box and WD-40 domain protein 1/11. (896 aa)
	FGIG_02408	Proteasome endopeptidase complex. (176 aa)
	FGIG_12152	Polyubiquitine protein. (136 aa)
	FGIG_08506	Polyubiquitin. (192 aa)
	FGIG_02853	Tyrosine-protein kinase. (866 aa)
	FGIG_11723	Small subunit ribosomal protein S27Ae. (149 aa)
	FGIG_02925	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (1230 aa)
	FGIG_10964	3-phosphoinositide-dependent protein kinase. (504 aa)
	FGIG_12476	P21-activated kinase 1. (138 aa)
	FGIG_05419	Serine/threonine-protein kinase PAK; Belongs to the protein kinase superfamily. (480 aa)
	FGIG_12477	Serine/threonine-protein kinase PAK 3. (247 aa)
	FGIG_06324	Serine/threonine-protein kinase PAK 1; Belongs to the protein kinase superfamily. (375 aa)

Your Current Organism:

Fasciola gigantica

NCBI taxonomy Id: 46835
Other names: F. gigantica

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGIG_02408	FGIG_02925	A0A504Y8I5	A0A504Z300	Proteasome endopeptidase complex.	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.	0.992
FGIG_02408	FGIG_03693	A0A504Y8I5	A0A504YV76	Proteasome endopeptidase complex.	Proteasome (Prosome macropain) 26S subunit ATPase 3; Belongs to the AAA ATPase family.	0.994
FGIG_02408	FGIG_03983	A0A504Y8I5	A0A504WSR5	Proteasome endopeptidase complex.	26S proteasome non-ATPase regulatory subunit.	0.996
FGIG_02408	FGIG_04163	A0A504Y8I5	A0A504YTP8	Proteasome endopeptidase complex.	Proteasome subunit beta.	0.999
FGIG_02408	FGIG_04727	A0A504Y8I5	A0A504YZ89	Proteasome endopeptidase complex.	Proteasome subunit beta.	0.999
FGIG_02408	FGIG_08506	A0A504Y8I5	A0A504YHV3	Proteasome endopeptidase complex.	Polyubiquitin.	0.943
FGIG_02408	FGIG_11723	A0A504Y8I5	A0A504Z6K4	Proteasome endopeptidase complex.	Small subunit ribosomal protein S27Ae.	0.970
FGIG_02408	FGIG_12152	A0A504Y8I5	A0A504YBE5	Proteasome endopeptidase complex.	Polyubiquitine protein.	0.939
FGIG_02853	FGIG_05419	A0A504YRP0	A0A504YKR3	Tyrosine-protein kinase.	Serine/threonine-protein kinase PAK; Belongs to the protein kinase superfamily.	0.424
FGIG_02853	FGIG_06018	A0A504YRP0	A0A504Z1X6	Tyrosine-protein kinase.	P21-activated kinase 1.	0.424
FGIG_02853	FGIG_06324	A0A504YRP0	A0A504YMP2	Tyrosine-protein kinase.	Serine/threonine-protein kinase PAK 1; Belongs to the protein kinase superfamily.	0.424
FGIG_02853	FGIG_06776	A0A504YRP0	A0A504Y4Y0	Tyrosine-protein kinase.	F-box and WD-40 domain protein 1/11.	0.462
FGIG_02853	FGIG_08197	A0A504YRP0	A0A504YUT0	Tyrosine-protein kinase.	Non-specific serine/threonine protein kinase.	0.424
FGIG_02853	FGIG_08506	A0A504YRP0	A0A504YHV3	Tyrosine-protein kinase.	Polyubiquitin.	0.674
FGIG_02853	FGIG_10964	A0A504YRP0	A0A504YJ83	Tyrosine-protein kinase.	3-phosphoinositide-dependent protein kinase.	0.652
FGIG_02853	FGIG_11723	A0A504YRP0	A0A504Z6K4	Tyrosine-protein kinase.	Small subunit ribosomal protein S27Ae.	0.657
FGIG_02853	FGIG_12152	A0A504YRP0	A0A504YBE5	Tyrosine-protein kinase.	Polyubiquitine protein.	0.674
FGIG_02853	FGIG_12476	A0A504YRP0	A0A504YJW5	Tyrosine-protein kinase.	P21-activated kinase 1.	0.424
FGIG_02853	FGIG_12477	A0A504YRP0	A0A504YLA2	Tyrosine-protein kinase.	Serine/threonine-protein kinase PAK 3.	0.424
FGIG_02925	FGIG_02408	A0A504Z300	A0A504Y8I5	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.	Proteasome endopeptidase complex.	0.992